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Thick-film carbon electrode deposited onto a biodegradable fibroin substrate for biosensing applications

  • This study addresses a proof-of-concept experiment with a biocompatible screen-printed carbon electrode deposited onto a biocompatible and biodegradable substrate, which is made of fibroin, a protein derived from silk of the Bombyx mori silkworm. To demonstrate the sensor performance, the carbon electrode is functionalized as a glucose biosensor with the enzyme glucose oxidase and encapsulated with a silicone rubber to ensure biocompatibility of the contact wires. The carbon electrode is fabricated by means of thick-film technology including a curing step to solidify the carbon paste. The influence of the curing temperature and curing time on the electrode morphology is analyzed via scanning electron microscopy. The electrochemical characterization of the glucose biosensor is performed by amperometric/voltammetric measurements of different glucose concentrations in phosphate buffer. Herein, systematic studies at applied potentials from 500 to 1200 mV to the carbon working electrode (vs the Ag/AgCl reference electrode) allow to determine the optimal working potential. Additionally, the influence of the curing parameters on the glucose sensitivity is examined over a time period of up to 361 days. The sensor shows a negligible cross-sensitivity toward ascorbic acid, noradrenaline, and adrenaline. The developed biocompatible biosensor is highly promising for future in vivo and epidermal applications.

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Metadaten
Author:Denise MolinnusORCiD, Kevin Alexander JanusORCiD, Anyelina C. Fang, Aleksander Drinic, Stefan AchtsnichtORCiD, Marius Köpf, Michael Keusgen, Michael Josef SchöningORCiD
DOI:https://doi.org/10.1002/pssa.202200100
ISSN:1862-6319
Parent Title (English):Physica status solidi (a)
Publisher:Wiley-VCH
Place of publication:Weinheim
Document Type:Article
Language:English
Year of Completion:2022
Date of the Publication (Server):2022/10/10
Tag:biocompatible materials; biodegradable electronic devices; biosensors; carbon electrodes; glucose
Volume:219
Issue:23
First Page:1
Last Page:9
Note:
Corresponding author: Michael J. Schöning
Link:https://doi.org/10.1002/pssa.202200100
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / Wiley-VCH
Open Access / Hybrid
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung