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Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue

  • The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.

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Metadaten
Author:Jan Hunker, Alexander JungORCiD, Matthias GoßmannORCiD, Peter LinderORCiD, Manfred StaatORCiD
DOI:https://doi.org/10.17185/duepublico/48750
ISBN:978-3-940402-22-6
Parent Title (English):3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen
Publisher:Universität Duisburg-Essen
Place of publication:Duisburg
Editor:Manfred Staat, Daniel Erni
Document Type:Conference Proceeding
Language:English
Year of Completion:2019
Creating Corporation:MedTech Symposium
Contributing Corporation:Young Researchers Academy
Date of the Publication (Server):2019/06/04
First Page:7
Last Page:8
Link:https://doi.org/10.17185/duepublico/48750
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Universität Duisburg-Essen
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell-Keine Bearbeitung