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Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling

  • A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician.

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Metadaten
Author:Denise MolinnusORCiD, G. Hardt, L. Käver, H.S. Willenberg, J.-C. Kröger, Arshak PoghossianORCiD, Michael Keusgen, Michael Josef SchöningORCiD
DOI:https://doi.org/10.1016/j.snb.2018.05.136
ISSN:0925-4005
Parent Title (English):Sensor and Actuators B: Chemical
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of Completion:2018
Date of the Publication (Server):2018/06/28
Volume:272
First Page:21
Last Page:27
Link:https://doi.org/10.1016/j.snb.2018.05.136
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / Elsevier