Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips
- The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.
| Author: | Denise MolinnusORCiD, Arshak PoghossianORCiD, Michael Keusgen, Evgeny Katz, Michael Josef SchöningORCiD |
|---|---|
| DOI: | https://doi.org/10.1002/elan.201700208 |
| ISSN: | 1521-4109 |
| Parent Title (English): | Electroanalysis |
| Publisher: | Wiley |
| Place of publication: | Weinheim |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2017 |
| Date of the Publication (Server): | 2017/08/21 |
| Volume: | 29 |
| Issue: | 8 |
| First Page: | 1840 |
| Last Page: | 1849 |
| Link: | https://doi.org/10.1002/elan.201700208 |
| Zugriffsart: | campus |
| Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Wiley |
