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Characterization of biodegradable polymers with capacitive field-effect sensors

  • In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance–voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.

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Metadaten
Author:Sebastian Schusser, Arshak PoghossianORCiD, Matthias Bäcker, Marcel Leinhos, Patrick Wagner, Michael Josef SchöningORCiD
DOI:https://doi.org/10.1016/j.snb.2012.07.099
ISSN:0925-4005
Parent Title (English):Sensors and actuators B: Chemical
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of Completion:2012
Date of the Publication (Server):2012/12/18
Tag:(Bio)degradation; C–V method; Field-effect sensor; Impedance spectroscopy; Poly(d,l-lacticacid); Real-time monitoring
Volume:187
First Page:2
Last Page:7
Note:
Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors"
Link:https://doi.org/10.1016/j.snb.2012.07.099
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / Elsevier
Licence (German):License LogoUrheberrechtlich geschützt