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Simulation of cardiac cell-seeded membranes using the edge-based smoothed FEM

  • We present an electromechanically coupled Finite Element model for cardiac tissue. It bases on the mechanical model for cardiac tissue of Hunter et al. that we couple to the McAllister-Noble-Tsien electrophysiological model of purkinje fibre cells. The corresponding system of ordinary differential equations is implemented on the level of the constitutive equations in a geometrically and physically nonlinear version of the so-called edge-based smoothed FEM for plates. Mechanical material parameters are determined from our own pressure-deflection experimental setup. The main purpose of the model is to further examine the experimental results not only on mechanical but also on electrophysiological level down to ion channel gates. Moreover, we present first drug treatment simulations and validate the model with respect to the experiments.

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Metadaten
Author:Ralf FrotscherORCiD, Matthias GoßmannORCiD, Hans-Jürgen Raatschen, Aysegül Temiz ArtmannORCiD, Manfred StaatORCiD
ISBN:978-3-319-02534-6 ; 978-3-319-02535-3
Parent Title (English):Shell and membrane theories in mechanics and biology. (Advanced structured materials ; 45)
Publisher:Springer
Place of publication:Heidelberg
Document Type:Part of a Book
Language:English
Year of Completion:2015
Date of the Publication (Server):2014/09/30
First Page:187
Last Page:212
Link:https://doi.org/10.1007/978-3-319-02535-3_11
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Chemie und Biotechnologie
FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / Fachbereich Maschinenbau und Mechatronik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Springer