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Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells

  • Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95% was achieved by depositing an intracellular total thermal energy with about 50% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65% after MNP were internalized inside cells.

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Metadaten
Author:Ulrich M. EngelmannORCiD, Anjali A.J. Roeth, Dietmar Eberbeck, Eva Miriam Buhl, Ulf Peter Neumann, Thomas Schmitz-Rode, Ioana Slabu
DOI:https://doi.org/10.1038/s41598-018-31553-9
ISSN:2045-2322
Parent Title (English):Scientific Reports
Publisher:Springer Nature
Place of publication:Cham
Document Type:Article
Language:English
Year of Completion:2018
Date of the Publication (Server):2019/11/19
Volume:8
Issue:1
First Page:Article number 13210
Link:https://doi.org/10.1038/s41598-018-31553-9
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
collections:Verlag / Springer Nature
Open Access / Gold
Licence (German):License LogoCreative Commons - Namensnennung