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⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron

  • Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.

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Metadaten
Author:Cornelia Hoehr, Elisabeth PaulßenORCiD, Francois Benard, Chris Jaeil Lee, Xinchi Hou, Brian Badesso, Simon Ferguson, Qing Miao, Hua Yang, Ken Buckley, Victoire Hanemaayer, Stefan Zeisler, Thomas Ruth, Anna Celler, Paul Schaffer
DOI:https://doi.org/10.1016/j.nucmedbio.2013.12.016
ISSN:1872-9614
Parent Title (English):Nuclear medicine and biology
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of Completion:2014
Date of the Publication (Server):2018/03/07
Volume:41
Issue:5
First Page:401
Last Page:406
Link:http://doi.org/10.1016/j.nucmedbio.2013.12.016
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Chemie und Biotechnologie
collections:Verlag / Elsevier