Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy
- Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
| Author: | Timo Immel, Martin Grützke, Anne-Katrin Späte, Ulrich Groth, Peter Öhlschläger, Thomas Huhn |
|---|---|
| DOI: | https://doi.org/10.1039/C2CC31624B |
| ISSN: | 1364-548X |
| Parent Title (English): | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| Place of publication: | Cambridge |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2012 |
| Date of the Publication (Server): | 2015/07/15 |
| Volume: | 48 |
| Issue: | 46 |
| First Page: | 5790 |
| Last Page: | 5792 |
| Link: | https://doi.org/10.1039/C2CC31624B |
| Zugriffsart: | campus |
| Institutes: | FH Aachen / Fachbereich Chemie und Biotechnologie |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Royal Society of Chemistry (RSC) |
