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Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study

  • Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20–30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = −0.097 (95% CI = −0.165; −0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.

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Metadaten
Author:Nthai E. Ramoshaba, Hugo W. Huisman, Leandi Lammertyn, Konstantin KotliarORCiD, Aletta E. Schutte, Wayne Smith
DOI:https://doi.org/10.1038/s41440-020-0487-0
ISSN:1348-4214
Parent Title (English):Hypertension Research
Publisher:Springer Nature
Place of publication:Osaka
Document Type:Article
Language:English
Year of Completion:2020
Date of the Publication (Server):2020/08/03
Issue:43
First Page:1231
Last Page:1238
Link:https://doi.org/10.1038/s41440-020-0487-0
Zugriffsart:weltweit
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
collections:Verlag / Springer Nature
Licence (German):License LogoCreative Commons - Namensnennung