Recent progress in silicon-based biologically sensitive field-effect devices
- Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor’s recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential.
| Author: | Arshak PoghossianORCiD, Michael Josef SchöningORCiD |
|---|---|
| DOI: | https://doi.org/10.1016/j.coelec.2021.100811 |
| ISSN: | 2451-9103 |
| Parent Title (English): | Current Opinion in Electrochemistry |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2021 |
| Date of the Publication (Server): | 2021/07/30 |
| Issue: | Article number: 100811 |
| Link: | https://doi.org/10.1016/j.coelec.2021.100811 |
| Zugriffsart: | bezahl |
| Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Elsevier |
