Fibroblast response to mechanical stress: role of the adhesion substrate : [abstract]

  • Mechanical stimulation of the cells resulted in evident changes in the cell morphology, protein composition and gene expression. Microscopically, additional formation of stress fibers accompanied by cell re-arrangements in a monolayer was observed. Also, significant activation of p53 gene was revealed as compared to control. Interestingly, the use of CellTech membrane coating induced cell death after mechanical stress had been applied. Such an effect was not detected when fibronectin had been used as an adhesion substrate.

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Metadaten
Author:Ilya DigelORCiD, Taylan Demirci, Jürgen TrzewikORCiD, Peter LinderORCiD, Aysegül Temiz ArtmannORCiD
DOI:https://doi.org/10.21269/336
Document Type:Conference Proceeding
Language:English
Year of Completion:2004
Publishing Institution:Fachhochschule Aachen
Contributing Corporation:International Conference on Physiological Biophysics <2004, Shanghai>
Tag:celldrum technology
GND Keyword:Fibroblast; Mechanische Beanspruchung
Source:Final program booklet / International Conference on Physiological Biophysics, China (Shanghai), Nov 9-13, 2004. - S. 41
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit

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