Field-effect Devices Functionalised with Gold-Nanoparticle/Macromolecule Hybrids: New Opportunities for a Label-Free Biosensing
- Field-effect capacitive electrolyte-insulator-semiconductor (EIS) sensors functionalised with citrate-capped gold nanoparticles (AuNP) have been used for the electrostatic detection of macromolecules by their intrinsic molecular charge. The EIS sensor detects the charge changes in the AuNP/macromolecule hybrids induced by the adsorption or binding events. A feasibility of the proposed detection scheme has been exemplary demonstrated by realising EIS sensors for the detection of poly-D-lysine molecules.
| Author: | Arshak PoghossianORCiD, M. H. Weil, Matthias Bäcker, D. Mayer, Michael Josef SchöningORCiD |
|---|---|
| DOI: | https://doi.org/10.1016/j.proeng.2012.09.136 |
| ISSN: | 1877-7058 |
| Parent Title (English): | Procedia Engineering |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2012 |
| Date of the Publication (Server): | 2012/12/18 |
| Issue: | 47 |
| First Page: | 273 |
| Last Page: | 276 |
| Note: | Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" |
| Link: | https://doi.org/10.1016/j.proeng.2012.09.136 |
| Zugriffsart: | campus |
| Institutes: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| FH Aachen / INB - Institut für Nano- und Biotechnologien | |
| collections: | Verlag / Elsevier |
