Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy
- Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
Author: | Timo Immel, Martin Grützke, Anne-Katrin Späte, Ulrich Groth, Peter Öhlschläger, Thomas Huhn |
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DOI: | https://doi.org/10.1039/C2CC31624B |
ISSN: | 1364-548X |
Parent Title (English): | Chemical Communications |
Publisher: | Royal Society of Chemistry |
Place of publication: | Cambridge |
Document Type: | Article |
Language: | English |
Year of Completion: | 2012 |
Volume: | 48 |
Issue: | 46 |
First Page: | 5790 |
Last Page: | 5792 |
Link: | https://doi.org/10.1039/C2CC31624B |
Zugriffsart: | campus |
Institutes: | FH Aachen / Fachbereich Chemie und Biotechnologie |
FH Aachen / INB - Institut für Nano- und Biotechnologien | |
collections: | Verlag / Royal Society of Chemistry (RSC) |