Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species

  • A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.

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Metadaten
Author:Tatsuo Yoshinobu, Ko-ichiro Miyamoto, Frederik WernerORCiD, Arshak PoghossianORCiD, Torsten WagnerORCiD, Michael Josef SchöningORCiD
DOI:https://doi.org/10.1146/annurev-anchem-061516-045158
ISSN:1936-1327
Parent Title (English):Annual Review of Analytical Chemistry
Publisher:Annual Reviews
Place of publication:Palo Alto, Calif.
Document Type:Article
Language:English
Year of Completion:2017
Volume:10
First Page:225
Last Page:246
Link:https://doi.org/10.1146/annurev-anchem-061516-045158
Zugriffsart:campus
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / Annual Reviews