The role of additives in moderating the influence of Fe(III) and Cu(II) on the radiochemical yield of [⁶⁸Ga(DOTATATE)]

  • [⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.

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Metadaten
Author:Elisabeth PaulßenORCiD, Nigel A. Lengkeek, Van So Le, Paul A. Pellegrini, Ivan Greguric, Ron Weiner
DOI:https://doi.org/10.1016/j.apradiso.2015.09.008
ISSN:1872-9800
Parent Title (English):Applied Radiation and Isotopes
Publisher:Elsevier
Place of publication:Amsterdam
Document Type:Article
Language:English
Year of Completion:2016
Date of the Publication (Server):2018/03/07
Volume:107
First Page:13
Last Page:16
Link:10.1016/j.apradiso.2015.09.008
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Chemie und Biotechnologie
collections:Verlag / Elsevier