Semi-automated system for concentrating 68Ga-eluate to obtain high molar and volume concentration of 68Ga-Radiopharmaca for preclinical applications
- 68Ga-radiopharmaceuticals are common in the field of Nuclear Medicine to visualize receptor-mediated processes. In contrast to straightforward labeling procedures for clinical applications, preclinical in vitro and in vivo applications are hampered for reasons like e.g. volume restriction, activity concentration, molar activity and osmolality. Therefore, we developed a semiautomatic system specifically to overcome these problems. A difficulty appeared unexpectedly, as intrinsic trace metals derived from eluate (Zn, Fe and Cu) are concentrated as well in amounts that influence radiochemical yield and thus lower molar activity.
| Author: | Eric de Blois, Rory M. S. de Zanger, Elisabeth PaulßenORCiD, Ho Sze Chan, Wouter A. P. Breeman |
|---|---|
| DOI: | https://doi.org/10.1016/j.nucmedbio.2018.06.006 |
| Parent Title (English): | Nuclear Medicine and Biology |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2018 |
| Date of the Publication (Server): | 2018/07/17 |
| Volume: | 64-65 |
| First Page: | 16 |
| Last Page: | 21 |
| Link: | https://doi.org/10.1016/j.nucmedbio.2018.06.006 |
| Zugriffsart: | weltweit |
| collections: | Verlag / Elsevier |
| Open Access / Hybrid |
