Refine
Year of publication
- 2017 (109) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (45)
- INB - Institut für Nano- und Biotechnologien (24)
- IfB - Institut für Bioengineering (14)
- Fachbereich Chemie und Biotechnologie (11)
- Fachbereich Maschinenbau und Mechatronik (11)
- Fachbereich Wirtschaftswissenschaften (10)
- Fachbereich Bauingenieurwesen (9)
- Fachbereich Luft- und Raumfahrttechnik (9)
- Fachbereich Elektrotechnik und Informationstechnik (8)
- Fachbereich Energietechnik (7)
Has Fulltext
- no (109)
Document Type
- Article (109) (remove)
Keywords
- 3D nonlinear finite element model (1)
- CNOT (1)
- Capacitive field-effect (1)
- Chemical images (1)
- Chemical sensor (1)
- Dehydrogenase (1)
- Diaphorase (1)
- Dry-low-NOx (DLN) combustion (1)
- EIS capacitive sensor (1)
- Effective modal mass (1)
- Electrolyte–insulator–semiconductor (1)
- Enzymatic biosensor (1)
- Enzyme logic gate (1)
- High hydrogen combustion (1)
- Hotelling’s T² test (1)
- Hydrogen combustion (1)
- Hydrogen gas turbine (1)
- LAPS (1)
- Light-addressable potentiometric sensor (1)
- Micromix combustion (1)
- Natural frequency (1)
- Negative impedance convertor (1)
- O2 plasma (1)
- Resonance-mode measurement (1)
- Simultaneous determination (1)
- Suspension bridge (1)
- Thin shell finite elements (1)
- XOR (1)
- annealing (1)
- change management (1)
- churches (1)
- complete block symmetry (1)
- diversity management (1)
- earthquake engineering (1)
- electrolyte-insulator semiconductor sensor (EIS) (1)
- engineering (1)
- equivalent stiffness (1)
- granular silo (1)
- hydroxylation (1)
- hypoplasticity (1)
- innovation management (1)
- likelihood ratio test (1)
- macro-element (1)
- nonlinear transient analyses (1)
- research association (1)
- surface functionalization (1)
- truss (1)
- uniformly most powerful invariant test (1)
- vault (1)
Is part of the Bibliography
- no (109)
The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems.
Enzyme-based logic gates and circuits - analytical applications and interfacing with electronics
(2017)
The paper is an overview of enzyme-based logic gates and their short circuits, with specific examples of Boolean AND and OR gates, and concatenated logic gates composed of multi-step enzyme-biocatalyzed reactions. Noise formation in the biocatalytic reactions and its decrease by adding a “filter” system, converting convex to sigmoid response function, are discussed. Despite the fact that the enzyme-based logic gates are primarily considered as components of future biomolecular computing systems, their biosensing applications are promising for immediate practical use. Analytical use of the enzyme logic systems in biomedical and forensic applications is discussed and exemplified with the logic analysis of biomarkers of various injuries, e.g., liver injury, and with analysis of biomarkers characteristic of different ethnicity found in blood samples on a crime scene. Interfacing of enzyme logic systems with modified electrodes and semiconductor devices is discussed, giving particular attention to the interfaces functionalized with signal-responsive materials. Future perspectives in the design of the biomolecular logic systems and their applications are discussed in the conclusion.
Neurophysiologisch ist das nicht alles zu erklären : Nahtoderfahrungen aus wissenschaftlicher Sicht
(2017)
This paper presents the results of an eigenvalue analysis of the Fatih Sultan Mehmet Bridge. A high-resolution finite element model was created directly from the available design documents. All physical properties of the structural components were included in detail, so no calibration to the measured data was necessary. The deck and towers were modeled with shell elements. A nonlinear static analysis was performed before the eigenvalue calculation. The calculated natural frequencies and corresponding mode shapes showed good agreement with the available measured ambient vibration data. The calculation of the effective modal mass showed that nine modes had single contributions higher than 5 % of the total mass. They were in a frequency range up to 1.2 Hz. The comparison of the results for the torsional modes especially demonstrated the advantage of using thin shell finite elements over the beam modeling approach.
The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.