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Keywords
- CNOT (1)
- Capacitive field-effect (1)
- Electrolyte–insulator–semiconductor (1)
- Enzyme logic gate (1)
- XOR (1)
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- INB - Institut für Nano- und Biotechnologien (11) (remove)
An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.