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Author

  • Matthias Gossmann (12)
  • Peter Linder (10)
  • Aysegül Temiz Artmann (7)
  • Gerhard Artmann (7)
  • Ilya Digel (7)
  • Dariusz Porst (4)
  • Peter Kayser (4)
  • Alexander Jung (3)
  • Aravind Hariharan Raman (3)
  • Manfred Staat (3)
  • Sonja Stoelzle-Feix (3)
  • András Horváth (2)
  • C. Preiß (2)
  • Elena Dragicevic (2)
  • Eylem Kurulgan Demirci (2)
  • Niels Fertig (2)
  • Rasha Bassam (2)
  • Taylan Demirci (2)
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  • Bioreaktor (1)
  • Blutzellenlagerung (1)
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  • Red blood cell storage (1)
  • Sepsis (1)
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  • Wundheilung (1)
  • carbonized rice husk (1)
  • celldrum technology (1)
  • contractile tension (1)
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Institute

  • IfB - Institut für Bioengineering (12)
  • Fachbereich Medizintechnik und Technomathematik (11)
  • Fachbereich Luft- und Raumfahrttechnik (1)

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Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds (2011)
Volker Seifarth ; D. Schehl ; Peter Linder ; Matthias Gossmann ; Ilya Digel ; Gerhard Artmann ; Dariusz Porst ; C. Preiß ; Peter Kayser ; O. Pack ; Aysegül Temiz Artmann
The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days.
Feasibility of an in-situ microbial decontamination of an ice-melting probe (2010)
W. Leimena ; Gerhard Artmann ; Bernd Dachwald ; Aysegül Temiz Artmann ; Matthias Gossmann ; Ilya Digel
Wound healing activity of carbonized rice husk (2013)
Nuraly Shardarbekovich Akimbekov ; Zulkhair Mansurov ; J. Jandosov ; Ilya Digel ; Matthias Gossmann ; Gerhard Artmann ; Aysegül Temiz Artmann ; Azhar A. Zhubanova
The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.
Alterations in human hemoglobin structure related to red blood cell storage (2011)
Rasha Bassam ; Gerhard Artmann ; Jürgen Hescheler ; T. Graef ; Aysegül Temiz Artmann ; Dariusz Porst ; Peter Linder ; Peter Kayser ; Vladimir Arinkin ; Matthias Gossmann ; Ilya Digel
The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.
rhAPC reduces the endothelial cell permeability via a decrease of cellular mechanical contractile tensions : [abstract] (2010)
Eylem Kurulgan Demirci ; Peter Linder ; Taylan Demirci ; Jessica R. Gierkowski ; Ilya Digel ; Matthias Gossmann ; Aysegül Temiz Artmann
In this study, the CellDrum technology quanitfying cellular mechanical tension on a pico-scale was used to investigate the effect of LPS (lipopolysaccharide) on HAoEC (Human Aortic Endothelial Cell) tension.
Celldrum electrode arrangement for measuring mechanical stress [Patent of invention] (2017)
Gerhard Artmann ; Peter Linder ; Robin Bayer ; Matthias Gossmann
The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.
rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells (2012)
Eylem Kurulgan Demirci ; Taylan Demirci ; Peter Linder ; Jürgen Trzewik ; Jessica Ricarda Gierkowski ; Matthias Gossmann ; Peter Kayser ; Dariusz Porst ; Ilya Digel ; Gerhard Artmann ; Aysegül Temiz Artmann
All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.
A higher-throughput approach to investigate cardiac contractility in vitro under physiological mechanical conditions (2020)
Matthias Gossmann ; Ulrich Thomas ; András Horváth ; Elena Dragicevic ; Sonja Stoelzle-Feix ; Alexander Jung ; Aravind Hariharan Raman ; Manfred Staat ; Peter Linder
Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility (2021)
Jan L. Hunker ; Matthias Gossmann ; Aravind Hariharan Raman ; Peter Linder
Engineering technology for plant physiology and plant stress research (2011)
C. Preiß ; Peter Linder ; K. Wendt ; M. Krystek ; Ilya Digel ; Matthias Gossmann ; Aysegül Temiz Artmann ; Dariusz Porst ; Peter Kayser ; Rasha Bassam ; Gerhard Artmann
Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.
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