• Deutsch
Login

Open Access

  • Home
  • Search
  • Browse
  • Publish
  • FAQ
  • Institutes
  • FH Aachen

IfB - Institut für Bioengineering

Refine

Author

  • Staat, Manfred (183)
  • Dachwald, Bernd (144)
  • Digel, Ilya (134)
  • Albracht, Kirsten (122)
  • Kotliar, Konstantin (91)
  • Artmann, Gerhard (85)
  • Temiz Artmann, Aysegül (72)
  • Behbahani, Mehdi (40)
  • Braunstein, Björn (39)
  • Seboldt, Wolfgang (39)
+ more

Year of publication

  • 2025 (7)
  • 2024 (18)
  • 2023 (13)
  • 2022 (30)
  • 2021 (40)
  • 2020 (38)
  • 2019 (57)
  • 2018 (51)
  • 2017 (41)
  • 2016 (36)
+ more

Institute

  • IfB - Institut für Bioengineering (772)
  • Fachbereich Medizintechnik und Technomathematik (614)
  • Fachbereich Luft- und Raumfahrttechnik (147)
  • Fachbereich Chemie und Biotechnologie (10)
  • Kommission für Forschung und Entwicklung (6)
  • Senat (2)
  • Arbeitsstelle fuer Hochschuldidaktik und Studienberatung (1)
  • Fachbereich Gestaltung (1)
  • Fachbereich Maschinenbau und Mechatronik (1)

Has Fulltext

  • no (710)
  • yes (62)

Language

  • English (690)
  • German (70)
  • Russian (12)

Document Type

  • Article (454)
  • Conference Proceeding (163)
  • Conference: Meeting Abstract (56)
  • Part of a Book (42)
  • Doctoral Thesis (20)
  • Report (12)
  • Book (8)
  • Conference Poster (4)
  • Lecture (3)
  • Other (3)
+ more

Keywords

  • Finite-Elemente-Methode (7)
  • Limit analysis (6)
  • Clusterion (5)
  • Shakedown analysis (5)
  • solar sail (5)
  • Air purification (4)
  • FEM (4)
  • Hämoglobin (4)
  • Lipopolysaccharide (4)
  • Luftreiniger (4)
+ more

Zugriffsart

  • weltweit (320)
  • campus (187)
  • bezahl (88)

Is part of the Bibliography

  • no (554)
  • yes (218)

772 search hits

  • 1 to 10
  • BibTeX
  • CSV
  • RIS
  • 10
  • 20
  • 50
  • 100

Sort by

  • Year
  • Year
  • Title
  • Title
  • Author
  • Author
Wound healing activity of heterogeneous composites on the basis of carbonized material (2014)
Akimbekov, Nuraly Sh. ; Digel, Ilya ; Abdieva, Gulzhamal ; Mansurov, Zulhair A. ; Zhubanova, Azhar A.
Recent comparative evaluation of various therapeutic methods has shown that the application of carbonized adsorbing materials to the necrosis zones is efficient: it lowers intoxication, adsorbs inflammation factors and products of necrosis, and improves indices of immunological reactivity. Due to their remarkable properties, nanostructured carbonized rice husks (CRH) can be used as sorbents for extraction of microorganisms and their toxins from chronic wounds. Our studies have demonstrated that the use of CRH indeed can develop into an outstanding method for stimulation of wound healing. We produced in rats infected injuries, which healing typically occurs in 12.2 ± 0.2 days. In the case, the CRH may offer multiple specific advantages in topical wound management through their high adsorption ability in respect of both Gram-positive and Gram-negative bacteria as well as bacterial toxins. Impregnation of carbonized materials by various essential oils can also enhance the wound healing significantly compared with the conventional carbonized materials. In our study, the combination of CRH with essential oils reduced healing time from 8.3 ± 0.7 days in the CRH-treated group to 7.1 ± 0.3 days in the heterogeneous composite-treated group. This work also demonstrated that the CRH exposure has no significant cytotoxicity in respect of normal human dermal fibroblasts (NHDF).
LPS adsorption by native and PEI-modified carbonized rice husk from protein solutions (2014)
Akimbekov, Nuraly Sh. ; Digel, Ilya ; Savitskaya, Irina S. ; Mansurov, Zulhair A. ; Zhubanova, Azhar A.
Removal of bacterial lipopolysaccharide (LPS) from aqueous solutions is a challenging bioengineering task because of LPS ubiquity as well as its very high physical and chemical stability. The present work describes the adsorption process using carbonized materials samples for the removal of endotoxins. Rice husks have been obtained by high-temperature carbonization and used as raw material in the preparation of granular activated carbon followed by chemical activation with polyethyleneimine (PEI) for increasing the sorption of bacterial endotoxins from dilute aqueous solutions and protein-rich solutions. A design for adsorption experiment was presented using a batch model, in order to compare kinetic and concentration parameters. The adsorption of LPS by the native material was extremely rapid, which suggests that the overall reaction rate in this case is controlled by mass transfer of LPS to the reactive sites on the surface. The LPS adsorption on the surfaces treated with PEI or water steam was significantly slower. We attribute these differences to changes in surface hydrophobicity and charge. Use of these adsorbents in a blood plasma purification system could be of great clinical interest because of the low production costs, the high adsorption efficiency, and the excellent biocompatibility data.
The susceptibility of chicken embryo to endotoxin solution eliminated by carbonized material (2015)
Tastambek, Kuanysh T. ; Akimbekov, Nuraly S. ; Digel, Ilya ; Zhubanova, Azhar A. ; Savitskaya, Irina S. ; Zh Abdieva, Gulzhamal ; Ualyeva, Perizat S.
Bacterial endotoxin (LPS) removal from aqueous solutions is a challenging bioengineering task because of its ubiquity and high physical and chemical stability. Nowadays, adsorption methods of LPS removal are regarded as most advantageous with many different adsorbent materials being developed. In this work, low-cost nanostructured carbonized material (rice husks-CRH) designed by us in accordance for LPS-adsorption. The purpose of the present investigation was to determine the susceptibility of chicken embryos to an injection of endotoxin and CRH-treated endotoxin in vivo during the period of development. Endotoxin extracted from cell walls of E. coli by LPS extraction kid was injected intravenously into fertile eggs, of varying ages. It has been observed that the susceptibility (the development of provisional organs, pyrogenicity, blood analysis and lethal dose (LD50)) of chicken embryos to endotoxin decreased daily as the embryo matured from day 10 to hatching, while CRH-treated LPS had showed weak effect. These data show that the toxin effects of LPS solution was eliminated by CRH, according to the increased resistance of embryos. We consider the obtained results on the basis of novel advanced and economically efficient material CRH are very promising as the increasing number of biotechnological and biomedical applications supposed to be endotoxin-free, as well as still persisting problems with purification of complex mixtures.
Lignite biosolubilization by bacillus sp. RKB 2 and characterization of its products (2020)
Akimbekov, Nuraly ; Digel, Ilya ; Qiao, Xiaohui ; Tastambek, Kuanysh ; Zhubanova, Azhar
Nowadays, the advancements of coal microbiology and biotechnology have been highly emphasized, providing leading-edge approaches in sustainable development of agriculture and the protection of the environment. The biosolubilization of low-rank coals, such as lignite and leonardite is a promising technology for converting these sedimentary rocks into valuable products. In this study, the process involved in lignite biosolubilization by Bacillus sp. RKB 2 was investigated. The biotransformed lignite and the produced humic substances were determined in vitro in a liquid medium and on a solid matrix. The bacterial strain was isolated from untreated Kazakhstani lignite and was shown to be capable of effectively solubilizing and transforming lignite (5% w/v). Fourier Transform Infrared (FTIR) and UHPLC-QqQ-MS/MS analyses were performed to examine the solubilization products and lignite humic substances processed by bacteria. The absorption peaks of FTIR showed the diverse nature of the bacteria-induced humic substances, and the vast majority of intense peaks detected are mainly below an m/z of 1000 Da (liquid chromatography-mass spectrometry [LC-MS] (QqQ)). Data analysis concluded that our isolate could depolymerize lignite and form bio-humic substances. Due to its ability to solubilize lignite Bacillus sp. RKB 2 may be useful in the coal-bed for in situ bioutilization of low-rank coal.
Evaluating the low-rank coal degradation efficiency bioaugmented with activated sludge (2024)
Kozhakhmetova, Marzhan ; Akimbekov, Nuraly ; Digel, Ilya ; Tastambek, Kuanysh
Microbial bioaugmentation of coal is considered as a viable and ecologically sustainable approach for the utilization of low-rank coals (LRC). The search for novel techniques to derive high-value products from LRC is currently of great importance. In response to this demand, endeavors have been undertaken to develop microbially based coal solubilization and degradation techniques. The impact of supplementing activated sludge (AS) as a microbial augmentation to enhance LRC biodegradation was investigated in this study. The LRC and their biodegradation products were characterized using the following methods: excitation-emission Matrices detected fluorophores at specific wavelength positions (O, E, and K peaks), revealing the presence of organic complexes with humic properties. FTIR indicated the increased amount of carboxyl groups in the bioaugmented coals, likely due to aerobic oxidation of peripheral non-aromatic structural components of coal. The bacterial communities of LRC samples are primarily composed of Actinobacteria (up to 36.2%) and Proteobacteria (up to 25.8%), whereas the Firmicutes (63.04%) was the most abundant phylum for AS. The community-level physiological profile analysis showed that the microbial community AS had high metabolic activity of compared to those of coal. Overall, the results demonstrated successful stimulation of LRC transformation through supplementation of exogenous microflora in the form of AS.
Icy ocean worlds - astrobiology research in Germany (2024)
Klenner, Fabian ; Baqué, Mickael ; Beblo-Vranesevic, Kristina ; Bönigk, Janine ; Boxberg, Marc S. ; Dachwald, Bernd ; Digel, Ilya ; Elsaesser, Andreas ; Espe, Clemens ; Funke, Oliver ; Hauber, Ernst ; Heinen, Dirk ; Hofmann, Florence ; Hortal Sánchez, Lucía ; Khawaja, Nozair ; Napoleoni, Maryse ; Plesa, Ana-Catalina ; Postberg, Frank ; Purser, Autun ; Rückriemen-Bez, Tina ; Schröder, Susanne ; Schulze-Makuch, Dirk ; Ulamec, Stephan ; de Vera, Jean-Pierre Paul
Icy bodies with subsurface oceans are a prime target for astrobiology investigations, with an increasing number of scientists participating in the planning, development, and realization of space missions to these worlds. Within Germany, the Ocean Worlds and Icy Moons working group of the German Astrobiology Society provides an invaluable platform for scientists and engineers from universities and other organizations with a passion for icy ocean worlds to share knowledge and start collaborations. We here present an overview about astrobiology research activities related to icy ocean worlds conducted either in Germany or in strong collaboration with scientists in Germany. With recent developments, Germany offers itself as a partner to contribute to icy ocean world missions.
AngioSim: A novel augmented-reality angiography simulator for radiation-free neurointerventional training (2025)
Minkenberg, Jan Gottfried ; Khandelwal, Smit ; Digel, Ilya ; Wiesmann, Martin ; Sichtermann, Thorsten
Cardiovascular diseases require fast and precise treatment, often involving angiography for diagnosis and intervention. However, training in angiographic procedures often entails exposure to ionizing radiation, which carries inherent risks. To reduce this exposure and enhance training realism, we developed AngioSim—a novel augmented-reality angiography simulation system combined with a vascular silicone simulator. This study evaluates the realism, effectiveness, and potential benefits of AngioSim for neurointerventional training. AngioSim was tested during neurointerventional training sessions with 24 physicians at RWTH Aachen University Hospital. Participants completed a questionnaire assessing realism, usefulness, and preferences compared to other simulators using a Likert scale. Responses were converted to binary categories and McNemar tests were applied for paired comparisons. A total of 92% of physicians rated guidewire and catheter visibility during fluoroscopy as sufficient, while 86% found RM and DSA simulations realistic. AngioSim was preferred over camera-based silicone simulators by 93%, and 96% of physicians rated it necessary for training—significantly more than other simulators (p < 0.05). These results demonstrate the high acceptance and perceived realism of the system and suggest that AngioSim offers advantages over existing training methods. AngioSim offers a realistic, cost-effective, and radiation-free training solution while maintaining the benefits of silicone models. It showed high utility for training purposes, making it a promising addition to neurointerventional programs.
Anpassung der Halswirbelsäule in der Schwerelosigkeit und das Risiko von Bandscheibenvorfällen (2025)
Belavy, Daniel ; Ambrecht, Gabriella ; Albracht, Kirsten ; Brisby, Helena ; Falla, Deborah ; Scheuring, Richard ; Sovelius, Roope ; Wilke, Hans-Joachim ; Greiner-Perth, Ann-Kathrin ; Vogt, Morten ; Liebsch, Christian ; Rennerfelt, Kajsa ; Martinez-Valdes, Eduardo ; Arvanitidis, Michail ; Goell, Fabian ; Braunstein, Björn ; Kaczorowski, Svenja ; Arora, Nitin Kumar ; Teichert, Florian ; Schüngel, Verena ; Moreira, Eva
Astronaut*innen haben ein etwa 20-mal höheres Risiko für Bandscheibenvorfälle (BSV) in der Halswirbelsäule (HWS) als Menschen auf der Erde. Die genauen Ursachen sind noch unklar. Durch die Untersuchung der Bindegewebe-, Muskel- und Knochenadaption der HWS vor und nach dem Aufenthalt im Weltall sollen die Mechanismen aufgeklärt werden, die das erhöhte Risiko von BSV in der HWS begünstigen.
Retinal vessel flicker light responsiveness and its relation to analysis protocols and static and metabolic data in healthy subjects (2025)
Artemiev, Dmitri ; Valmaggia, Christophe ; Tschuppert, Scott ; Kotliar, Konstantin ; Türksever, Cengiz ; Todorova, Margarita G.
Background: The aim of this study was to assess the agreement between different analysis protocols for the determination of retinal vessel dilation response to flicker light (FL) and its relation to static and metabolic parameters of retinal vessels in healthy subjects. Methods: In total, 24 right eyes of 24 healthy controls (mean age: 36.04 ± SD 14.4 years) who underwent dynamic and static retinal diameter and oxygen saturation measurements on a Retinal Vessel Analyzer (RVA, Imedos, Jena, Germany) were included. Using repeated video analyses, responses to FL were measured with RVA. These measurements were conducted at three specific retinal locations: within the superotemporal area—within a distance of less than one optic disk (OD) diameter to optic nerve head (ONH) (group 1); greater than one OD diameter to ONH (group 2); and areas near the ONH within the VesselMap region (group 3). For comparability, the static and oxygen saturation parameters were also calculated in the superotemporal peripapillary area using the VesselMap tool of the RVA and were evaluated in relation to the corresponding dynamic area (group 3). Results: In all groups, the vascular FL response of arteries was less pronounced compared to venules (p = 0.0014). Even though FL responses (mean ± SD: FL-A; FL-V) in group 1 were more pronounced (3.36 ± 2.31; 4.42 ± 1.69) compared to those in group 2 (2.97 ± 2.40; 4.08 ± 1.55) and group 3 (2.84 ± 2.29; 4.21 ± 2.03), they did not reach statistically significant values. The mean flicker response of venules (VDil) in all groups showed negative correlations to the corresponding static parameter: central retinal venous equivalent (CRV) (r = −0.0437; p = 0.015). The mean flicker response of arteries (ADil) in all groups showed negative correlations to the corresponding metabolic parameter: arterio-venous oxygen extraction fraction (r = −0.101; p = 0.041). Conclusions: Our study confirms that the flicker light response, despite slight variations in its duration and location, allows for reliable measurements, proving the Retinal Vessel Analyzer to be a valuable diagnostic tool. Furthermore, we were able to highlight the relationship between the dynamic and metabolic components of retinal supply, which enables early diagnosis concerning the development of diseases within this spectrum.
Screening halotolerant bacteria for their potential as plant growth-promoting and coal-solubilizing agents (2025)
Digel, Ilya ; Akimbekov, Nuraly ; Kamenov, Bekzat ; Altynbay, Nazym ; Tastambek, Kuanysh ; Zha, Jian ; Tepecik, Atakan ; Sakhanova, Svetlana K.
The bioconversion of salinized land into healthy agricultural systems by utilizing low-rank coal (LRC) is a strategic approach for sustainable agricultural development. The aims of this study were: (1) to isolate bacterial strains associated with the rhizosphere of native plants in coal-containing soils, (2) to characterize their plant growth-promoting (PGP) and coal-solubilizing capabilities under laboratory conditions and (3) to evaluate their influence on the germination and growth of chia seeds under saline stress. Fourteen bacterial cultures were isolated from the rhizosphere of Artemisia annua L. using culture media containing salt and coal. Based on their PGP activities (nitrogen fixation, phosphate solubilization, siderophore and indole-3-acetic acid production), five strains were selected, belonging to the genera Bacillus, Phyllobacterium, Arthrobacter, and Pseudomonas. Solubilization assays were conducted to confirm the ability of these strains to utilize coal efficiently. Finally, the selected strains were inoculated with chia seeds (Salvia hispanica L.) to evaluate their ameliorating effect under saline stress conditions in coal-containing media. Inoculation with A. subterraneus Y1 resulted in the highest germination and growth metrics of chia seeds. A positive but comparatively weaker response was observed with P. frederiksbergensis AMA1 and B. paramycoides Lb-1 as inoculants. Coal inoculated with halotolerant bacteria can serve as the foundation for humified organic matter in salt-affected environments. The selected halotolerant bacteria enhance coal biotransformation while exhibiting PGP traits.
  • 1 to 10

OPUS4 Logo

  • Contact
  • Imprint
  • Sitelinks