Conference Proceeding
Refine
Year of publication
- 2024 (5)
- 2023 (4)
- 2022 (8)
- 2021 (7)
- 2020 (4)
- 2019 (11)
- 2018 (7)
- 2017 (16)
- 2016 (17)
- 2015 (14)
- 2014 (15)
- 2013 (10)
- 2012 (19)
- 2011 (6)
- 2010 (5)
- 2009 (7)
- 2008 (6)
- 2007 (4)
- 2006 (34)
- 2005 (4)
- 2004 (5)
- 2003 (10)
- 2002 (2)
- 2001 (3)
- 2000 (2)
- 1999 (2)
- 1998 (2)
- 1997 (3)
- 1996 (1)
- 1995 (1)
- 1989 (1)
- 1985 (1)
- 1981 (1)
- 1980 (1)
- 1978 (2)
- 1975 (2)
- 1973 (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (243) (remove)
Document Type
- Conference Proceeding (243) (remove)
Keywords
- Biosensor (25)
- CAD (11)
- Finite-Elemente-Methode (11)
- civil engineering (11)
- Bauingenieurwesen (10)
- Einspielen <Werkstoff> (6)
- shakedown analysis (6)
- Clusterion (4)
- Limit analysis (4)
- Natural language processing (4)
Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).