Refine
Year of publication
- 2024 (2)
- 2023 (8)
- 2022 (13)
- 2021 (8)
- 2020 (12)
- 2019 (17)
- 2018 (18)
- 2017 (12)
- 2016 (36)
- 2015 (30)
- 2014 (28)
- 2013 (29)
- 2012 (26)
- 2011 (28)
- 2010 (26)
- 2009 (24)
- 2008 (16)
- 2007 (20)
- 2006 (17)
- 2005 (20)
- 2004 (15)
- 2003 (14)
- 2002 (18)
- 2001 (18)
- 2000 (12)
- 1999 (16)
- 1998 (31)
- 1997 (25)
- 1996 (19)
- 1995 (36)
- 1994 (29)
- 1993 (21)
- 1992 (27)
- 1991 (15)
- 1990 (20)
- 1989 (20)
- 1988 (19)
- 1987 (16)
- 1986 (11)
- 1985 (7)
- 1984 (10)
- 1983 (10)
- 1982 (3)
- 1981 (3)
- 1980 (3)
- 1979 (8)
- 1978 (2)
- 1976 (2)
- 1975 (3)
- 1973 (2)
- 1972 (2)
- 1971 (2)
Document Type
- Article (585)
- Patent (117)
- Book (65)
- Conference Proceeding (33)
- Part of a Book (21)
- Report (4)
- Doctoral Thesis (3)
- Preprint (1)
Language
- English (522)
- German (304)
- Multiple languages (2)
- Spanish (1)
Has Fulltext
- no (829) (remove)
Keywords
- Heparin (3)
- Chemometrics (2)
- IR spectroscopy (2)
- NMR spectroscopy (2)
- Principal component analysis (2)
- Standardization (2)
- (R)- or (S)- gamma-valerolactone (1)
- 4-hydroxy valeric acid (1)
- Alginate beads (1)
- Analytics (1)
- Authenticity (1)
- Bioeconomy (1)
- Bioethanol (1)
- Biomass (1)
- Biorefinery (1)
- Biorefinery definitions (1)
- Bladder (1)
- Bragg peak (1)
- CRISPR/Cas9 (1)
- Chimeric liver-humanized mice (1)
- Chiralidon-R (1)
- Chiralidon-S (1)
- Crude heparin (1)
- Cyclotron production (1)
- Decentral (1)
- Dehydrogenase (1)
- Detergent protease (1)
- Deuterated solvents (1)
- Deuterium NMR (1)
- Diaphorase (1)
- Drug distribution (1)
- Drug metabolism (1)
- Enzymatic biosensor (1)
- Extracellular enzymes (1)
- Ga-68 (1)
- Growth modelling (1)
- Hypersecretion (1)
- IR (1)
- Inorganic ions (1)
- Introduction (1)
- Ions (1)
- Knockout mice (1)
- Levulinic acid (1)
- Lignocellulose feedstook (1)
- Linear discriminant analysis (1)
- Manufacturer (1)
- Marker-free mutagenesis (1)
- Mechanical (1)
- Mechanical simulation (1)
- Medical radionuclide production (1)
- Metal contaminants (1)
- Microfluidic solvent extraction (1)
- Minor chemistry (1)
- Molecular modelling (1)
- Molecular weight determination (1)
- NMR (1)
- On-site (1)
- P2G (1)
- PLS-regression (1)
- Physical chemistry (1)
- Physical chemistry basics (1)
- Physical chemistry starters (1)
- Physikalische Chemie (1)
- Pre-treatment (1)
- Process schemes (1)
- Quality control (1)
- Quantum chemistry (1)
- Reconstruction (1)
- Renewable resources (1)
- Simultaneous determination (1)
- Soft independent modeling of class analogy (1)
- Stenotrophomonas maltophilia (1)
- Thermodynamics as minor (1)
- Toxicology (1)
- USP (1)
- Uracil-phosphoribosyltransferase (1)
- Ureter (1)
- actuator-sensor system (1)
- aspergillus (1)
- bacterial cellulose (1)
- bi-enzyme biosensor (1)
- bioavailability (1)
- biodegradable polymers (1)
- biological dosimeter (1)
- biomethane (1)
- borehole disposal (1)
- bubble column (1)
- capacitive field-effect sensor (1)
- coculture (1)
- deficit irrigation (1)
- disposal facility (1)
- drug metabolising enzymes (1)
- drug–drug interactions (1)
- elastomers (1)
- enzyme kinetics (1)
- enzyme-logic gate (1)
- exopolysaccharides (1)
- filamentous fungi (1)
- genome engineering (1)
- geological disposal (1)
- glycine (1)
- human metabolites (1)
- hydrogel (1)
- hydrogels (1)
- light-addressable electrode (1)
- light-addressable potentiometric sensor (1)
- mechanical properties (1)
- methanation (1)
- microfluidics (1)
- micronutrients (1)
- neutrons (1)
- nuclear waste (1)
- onion (1)
- optical fibers (1)
- penicillinase (1)
- plug flow reactor (1)
- polyaspartic acid (1)
- prebiotic (1)
- proton therapy (1)
- protons (1)
- pullulan (1)
- qNMR (1)
- relative dosimetry (1)
- retention time (1)
- rubber (1)
- superabsorbent polymers (1)
- supramolecular structures (1)
- swelling properties (1)
- theory and modeling (1)
- tobacco mosaic virus (TMV) (1)
- transporters (1)
- urease (1)
- water economy (1)
- yield (1)
Institute
- Fachbereich Chemie und Biotechnologie (829) (remove)
Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated.
In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).