Refine
Year of publication
- 2020 (171) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (57)
- IfB - Institut für Bioengineering (33)
- Fachbereich Luft- und Raumfahrttechnik (30)
- Fachbereich Energietechnik (25)
- Fachbereich Elektrotechnik und Informationstechnik (20)
- ECSM European Center for Sustainable Mobility (14)
- Fachbereich Maschinenbau und Mechatronik (11)
- Fachbereich Wirtschaftswissenschaften (11)
- INB - Institut für Nano- und Biotechnologien (11)
- Fachbereich Chemie und Biotechnologie (10)
Language
- English (171) (remove)
Document Type
- Article (101)
- Conference Proceeding (46)
- Part of a Book (16)
- Book (2)
- Conference Poster (2)
- Doctoral Thesis (2)
- Conference: Meeting Abstract (1)
- Other (1)
Keywords
- MINLP (3)
- Additive manufacturing (2)
- Adjacent buildings (2)
- Experimental validation (2)
- Historical centres (2)
- Shake table test (2)
- Stone masonry (2)
- rebound-effect (2)
- sustainability (2)
- 3D printing (1)
- Acceptance (1)
- Adaptive control (1)
- Atmospheres (1)
- Biofuel (1)
- Biorefinery (1)
- Blind prediction competition (1)
- Brownian Pillow (1)
- Bumblebees (1)
- Butanol (1)
- Capacity Building Higher Education (1)
- Capacity Curve (1)
- Case study (1)
- Change culture (1)
- Clostridium acetobutylicum (1)
- Conservation laws (1)
- Cooling system (1)
- Crámer–von-Mises distance (1)
- Digital manufacturing (1)
- Digitalization (1)
- Dimensional splitting (1)
- Efficiency optimization (1)
- Engineering optimisation (1)
- Engineering optimization (1)
- Entropy solution (1)
- Ethics (1)
- European Framework and South East Asia (1)
- Exoplanet (1)
- Exponential time differencing (1)
- Finite difference methods (1)
- Flight control (1)
- Glass powder (1)
- Higher-order codes (1)
- Hoeffding-Blum-Kiefer-Rosenblatt independence test (1)
- Human Development Index (1)
- Human factors (1)
- Human-robot collaboration (1)
- INODIS (1)
- Implicit methods (1)
- Incomplete data (1)
- Industrial optimisation (1)
- Interactive process mining (1)
- Interior transmission eigenvalues (1)
- Iterative learning control (1)
- L-PBF (1)
- Laser processing (1)
- Lean thinking (1)
- Lignocellulose (1)
- MAV (1)
- MILP (1)
- Malaysian Automotive Industry (1)
- Marginal homogeneity test (1)
- Masonry structures (1)
- Matrix exponential (1)
- Melting (1)
- Methodology (1)
- Mixed-integer programming (1)
- Monotone methods (1)
- Multi-dimensional partial differential equations (1)
- Neo-Deterministic (1)
- Network design (1)
- Nonlinear PDEs (1)
- OR 2019 (1)
- Objective data (1)
- Obstacle avoidance (1)
- Paired sample (1)
- Payload (1)
- Piecewise linearization (1)
- Powertrain (1)
- Process engineering (1)
- Pumping systems (1)
- Rapid manufacturing (1)
- Rapid prototyping (1)
- Reaction-diffusion systems (1)
- Real distinct pole (1)
- Resampling test (1)
- Resilience assessment (1)
- Resilience metric graph theory (1)
- Resilient infrastructure (1)
- Robotic rehabilitation (1)
- SSE) JEL : O33 (1)
- Seismic Hazard (1)
- Source term (1)
- Spectroscopy (1)
- Technical Operations Research (1)
- Technology Transfer (1)
- Transit (1)
- UAV (1)
- Vulnerability Curves (1)
- Water distribution system (1)
- Water supply system (1)
- agility (1)
- anticipation strategy (1)
- automotive (1)
- business analytics (1)
- community dwelling (1)
- connection detail (1)
- corporate sustainability (1)
- critical (1)
- decision analytics (1)
- digital economy (1)
- digital twin (1)
- earthquake (1)
- efficiency side-effects (1)
- elastic scattering (1)
- fault detection (1)
- grey energy (1)
- healthy aging (1)
- in-plane (1)
- industry 4.0 (1)
- jevons paradox (1)
- literature (1)
- marketing (1)
- mathematical optimization (1)
- method of fundamental solutions (1)
- not identically distributed (1)
- out-of-plane (1)
- prevention (1)
- psychosocial (1)
- random effects meta-regression model (1)
- resource abundance (1)
- review (1)
- socio-economic welfare (1)
- systematic (1)
- water supply system (1)
Is part of the Bibliography
- no (171)
Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO–K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO–K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.