Refine
Year of publication
Document Type
- Article (542)
- Conference Proceeding (63)
- Part of a Book (11)
- Book (2)
- Other (2)
- Report (2)
- Patent (1)
Language
- English (551)
- German (71)
- Multiple languages (1)
Keywords
- Biosensor (7)
- Graduiertentagung (5)
- LAPS (4)
- field-effect sensor (4)
- hydrogen peroxide (4)
- Field-effect sensor (3)
- Label-free detection (3)
- Light-addressable potentiometric sensor (3)
- biosensors (3)
- capacitive field-effect sensor (3)
- tobacco mosaic virus (TMV) (3)
- Bacillus atrophaeus (2)
- Calorimetric gas sensor (2)
- Capacitive field-effect sensor (2)
- Graduate symposium (2)
- Hydrogen peroxide (2)
- Raman spectroscopy (2)
- Tobacco mosaic virus (TMV) (2)
- acetoin (2)
- capacitive field-effect sensors (2)
Institute
- Fachbereich Medizintechnik und Technomathematik (603)
- INB - Institut für Nano- und Biotechnologien (526)
- Fachbereich Chemie und Biotechnologie (40)
- FH Aachen (5)
- Nowum-Energy (5)
- Fachbereich Energietechnik (4)
- Institut fuer Angewandte Polymerchemie (3)
- Arbeitsstelle fuer Hochschuldidaktik und Studienberatung (1)
- Fachbereich Elektrotechnik und Informationstechnik (1)
The coupling of ligand-stabilized gold nanoparticles with field-effect devices offers new possibilities for label-free biosensing. In this work, we study the immobilization of aminooctanethiol-stabilized gold nanoparticles (AuAOTs) on the silicon dioxide surface of a capacitive field-effect sensor. The terminal amino group of the AuAOT is well suited for the functionalization with biomolecules. The attachment of the positively-charged AuAOTs on a capacitive field-effect sensor was detected by direct electrical readout using capacitance-voltage and constant capacitance measurements. With a higher particle density on the sensor surface, the measured signal change was correspondingly more pronounced. The results demonstrate the ability of capacitive field-effect sensors for the non-destructive quantitative validation of nanoparticle immobilization. In addition, the electrostatic binding of the polyanion polystyrene sulfonate to the AuAOT-modified sensor surface was studied as a model system for the label-free detection of charged macromolecules. Most likely, this approach can be transferred to the label-free detection of other charged molecules such as enzymes or antibodies.