Refine
Year of publication
- 2016 (157) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (41)
- Fachbereich Chemie und Biotechnologie (29)
- IfB - Institut für Bioengineering (27)
- Fachbereich Elektrotechnik und Informationstechnik (26)
- Fachbereich Luft- und Raumfahrttechnik (22)
- Fachbereich Bauingenieurwesen (13)
- INB - Institut für Nano- und Biotechnologien (13)
- Fachbereich Maschinenbau und Mechatronik (12)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (11)
- Fachbereich Energietechnik (9)
Has Fulltext
- no (157) (remove)
Language
- English (157) (remove)
Document Type
- Article (79)
- Conference Proceeding (62)
- Part of a Book (7)
- Book (3)
- Conference: Meeting Abstract (3)
- Report (2)
- Doctoral Thesis (1)
Keywords
- Technical Operations Research (2)
- Additive Manufacturing (1)
- Annulus Fibrosus (1)
- Archeology (1)
- Assessment (1)
- Asymptotic efficiency (1)
- Bacillus atrophaeus (1)
- Balance (1)
- Balanced hypergraph (1)
- Building Culture (1)
- Building Systems (1)
- Business Simulations (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- Cartography (1)
- CellDrum (1)
- Censored data (1)
- Co-managed care (1)
- Collaborative robot (1)
- Computational biomechanics (1)
- Controller Parameter (1)
- DNA biosensor (1)
- Disc Degeneration (1)
- Diversity (1)
- Drinking Water Supply (1)
- Drug simulation (1)
- Duality (1)
- Elderly (1)
- Electromechanical modeling (1)
- Engineering Education (1)
- Eutectic Silver Copper alloy (1)
- External knee adduction moments (1)
- Fall prevention (1)
- Field effect (1)
- Frequency adaption (1)
- Gamification (1)
- Gender (1)
- Ground-level falls (1)
- Hall’s Theorem (1)
- Heart tissue culture (1)
- Higher Education (1)
- Hodgkin–Huxley models (1)
- Homogenization (1)
- Human-Robot interaction (1)
- Hypergraph (1)
- Induced pluripotent stem cells (1)
- Infrastructures (1)
- Inotropic compounds (1)
- Intervertebral Disc (1)
- Intradiscal Pressure (1)
- Inverse dynamic problem (1)
- Inverse kinematic problem (1)
- Ion channels (1)
- Koenig’s Theorem (1)
- LAPS (1)
- Label-free detection (1)
- Land Survey and Measurement Systems (1)
- Layer-by-layer adsorption (1)
- Level Control System (1)
- Manipulated variables (1)
- Matching (1)
- Mixed Integer Programming (1)
- Mixed-Integer Nonlinear Optimisation (1)
- Mobility (1)
- Mobility tests (1)
- Musculoskeletal model (1)
- Nucleus Pulposus (1)
- Optimal Closed Loop (1)
- Optimal Topology (1)
- Optimization (1)
- Parametric Design (1)
- Parametric Modelling (1)
- Path planning (1)
- Pharmacology (1)
- Poly(allylamine hydrochloride) (1)
- Porositat (1)
- Product-integration (1)
- Reference Process Model (1)
- Response Surface Method (1)
- SLM (1)
- Safety concept (1)
- Semi-parametric random censorship model (1)
- Serious Games (1)
- Solver Per- formance (1)
- Structuralist Architecture (1)
- Subject-oriented Business Process Management (1)
- Survival analysis (1)
- System Design (1)
- System Design Problem (1)
- Technical Operation Research (1)
- Telecommunications Industry. (1)
- Tinetti test (1)
- Vertex cover (1)
- Volterra integral equation (1)
- Workspace monitoring (1)
- biosensors (1)
- building industry (1)
- chemical sensor (1)
- diversity (1)
- eTOM (1)
- endospores (1)
- energy disspation (1)
- engineering education (1)
- friction (1)
- hiPS cardiomyocytes (1)
- immobilization (1)
- impulsive effects (1)
- industrial research (1)
- ingot (1)
- innovation (1)
- iron and steel industry (1)
- light-addressable potentiometric sensor (1)
- liquid-storage tank (1)
- liquid-structure interaction (1)
- materials technology (1)
- metal structure (1)
- organosilanes (1)
- plug-based microfluidic device (1)
- research project (1)
- research report (1)
- resistance of materials (1)
- seismic response (1)
- silanization (1)
- social responsible engineering (1)
- steel (1)
- structure-soil-structure interaction (1)
- wave run-up (1)
Purpose
Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena.
Methods
Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model.
Results
A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained.
Conclusions
The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.
Self-aeration is traditionally explained by the water turbulent boundary layer outer edge intersection with the free surface. This paper presents a discussion on the commonly accepted hypothesis behind the computation of the critical point of self-aeration in spillway flows and a new formulation is proposed based on the existence of a developing air flow over the free surface. Upstream of the inception point of self-aeration, some surface roughening has been often reported in previous studies which consequently implies some entrapped air transport and air–water flows coupling. Such air flow is proven in this study by presenting measured air velocities and computing the air boundary layer thickness for a 1V:2H smooth chute flow. Additionally, the growth rate of free surface waves has been analysed by means of Ultrasonic Sensors measurements, obtaining also the entrapped air concentration. High-speed camera imaging has been used for qualitative study of the flow perturbations.
Operational Modal Analysis (OMA) is a promising candidate for flutter testing and Structural Health Monitoring (SHM) of aircraft wings that are passively excited by wind loads. However, no studies have been published where OMA is tested in transonic flows, which is the dominant condition for large civil aircraft and is characterized by complex and unique aerodynamic phenomena. We use data from the HIRENASD large-scale wind tunnel experiment to automatically extract modal parameters from an ambiently excited wing operated in the transonic regime using two OMA methods: Stochastic Subspace Identification (SSI) and Frequency Domain Decomposition (FDD). The system response is evaluated based on accelerometer measurements. The excitation is investigated from surface pressure measurements. The forcing function is shown to be non-white, non-stationary and contaminated by narrow-banded transonic disturbances. All these properties violate fundamental OMA assumptions about the forcing function. Despite this, all physical modes in the investigated frequency range were successfully identified, and in addition transonic pressure waves were identified as physical modes as well. The SSI method showed superior identification capabilities for the investigated case. The investigation shows that complex transonic flows can interfere with OMA. This can make existing approaches for modal tracking unsuitable for their application to aircraft wings operated in the transonic flight regime. Approaches to separate the true physical modes from the transonic disturbances are discussed.
We investigate the suitability of selected measures of complexity based on recurrence quantification analysis and recurrence networks for an identification of pre-seizure states in multi-day, multi-channel, invasive electroencephalographic recordings from five epilepsy patients. We employ several statistical techniques to avoid spurious findings due to various influencing factors and due to multiple comparisons and observe precursory structures in three patients. Our findings indicate a high congruence among measures in identifying seizure precursors and emphasize the current notion of seizure generation in large-scale epileptic networks. A final judgment of the suitability for field studies, however, requires evaluation on a larger database.
Given the strong increase in regulatory requirements for business processes the management of business process compliance becomes a more and more regarded field in IS research. Several methods have been developed to support compliance checking of conceptual models. However, their focus on distinct modeling languages and mostly linear (i.e., predecessor-successor related) compliance rules may hinder widespread adoption and application in practice. Furthermore, hardly any of them has been evaluated in a real-world setting. We address this issue by applying a generic pattern matching approach for conceptual models to business process compliance checking in the financial sector. It consists of a model query language, a search algorithm and a corresponding modelling tool prototype. It is (1) applicable for all graph-based conceptual modeling languages and (2) for different kinds of compliance rules. Furthermore, based on an applicability check, we (3) evaluate the approach in a financial industry project setting against its relevance for decision support of audit and compliance management tasks.