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Digital twins enable the modeling and simulation of real-world entities (objects, processes or systems), resulting in improvements in the associated value chains. The emerging field of quantum computing holds tremendous promise forevolving this virtualization towards Quantum (Digital) Twins (QDT) and ultimately Quantum Twins (QT). The quantum (digital) twin concept is not a contradiction in terms - but instead describes a hybrid approach that can be implemented using the technologies available today by combining classicalcomputing and digital twin concepts with quantum processing. This paperpresents the status quo of research and practice on quantum (digital) twins. It alsodiscuses their potential to create competitive advantage through real-timesimulation of highly complex, interconnected entities that helps companies better
address changes in their environment and differentiate their products andservices.
In this paper research activities developed within the FutureCom project are presented. The project, funded by the European Metrology Programme for Innovation and Research (EMPIR), aims at evaluating and characterizing: (i) active devices, (ii) signal- and power integrity of field programmable gate array (FPGA) circuits, (iii) operational performance of electronic circuits in real-world and harsh environments (e.g. below and above ambient temperatures and at different levels of humidity), (iv) passive inter-modulation (PIM) in communication systems considering different values of temperature and humidity corresponding to the typical operating conditions that we can experience in real-world scenarios. An overview of the FutureCom project is provided here, then the research activities are described.
It was generally believed that coal sources are not favorable as live-in habitats for microorganisms due to their recalcitrant chemical nature and negligible decomposition. However, accumulating evidence has revealed the presence of diverse microbial groups in coal environments and their significant metabolic role in coal biogeochemical dynamics and ecosystem functioning. The high oxygen content, organic fractions, and lignin-like structures of lower-rank coals may provide effective means for microbial attack, still representing a greatly unexplored frontier in microbiology. Coal degradation/conversion technology by native bacterial and fungal species has great potential in agricultural development, chemical industry production, and environmental rehabilitation. Furthermore, native microalgal species can offer a sustainable energy source and an excellent bioremediation strategy applicable to coal spill/seam waters. Additionally, the measures of the fate of the microbial community would serve as an indicator of restoration progress on post-coal-mining sites. This review puts forward a comprehensive vision of coal biodegradation and bioprocessing by microorganisms native to coal environments for determining their biotechnological potential and possible applications.
Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30–40% and phosphate to nearly 80%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.
The recent advances in microbiology have shed light on understanding the role of vitamins beyond the nutritional range. Vitamins are critical in contributing to healthy biodiversity and maintaining the proper function of gut microbiota. The sharing of vitamins among bacterial populations promotes stability in community composition and diversity; however, this balance becomes disturbed in various pathologies. Here, we overview and analyze the ability of different vitamins to selectively and specifically induce changes in the intestinal microbial community. Some schemes and regularities become visible, which may provide new insights and avenues for therapeutic management and functional optimization of the gut microbiota.
In times of short product life cycles, additive manufacturing and rapid tooling are important methods to make tool development and manufacturing more efficient. High-performance polymers are the key to mold production for prototypes and small series. However, the high temperatures during vulcanization injection molding cause thermal aging and can impair service life. The extent to which the thermal stress over the entire process chain stresses the material and whether it leads to irreversible material aging is evaluated. To this end, a mold made of PEEK is fabricated using fused filament fabrication and examined for its potential application. The mold is heated to 200 ◦C, filled with rubber, and cured. A differential scanning calorimetry analysis of each process step illustrates the crystallization behavior and first indicates the material resistance. It shows distinct cold crystallization regions at a build chamber temperature of 90 ◦C. At an ambient temperature above Tg, crystallization of 30% is achieved, and cold crystallization no longer occurs. Additional tensile tests show a decrease in tensile strength after ten days of thermal aging. The steady decrease in recrystallization temperature indicates degradation of the additives. However, the tensile tests reveal steady embrittlement of the material due to increasing crosslinking.
Inhaltsverzeichnis:
06| "WIR" werden nachhaltig
10| Der Kraft-Stoff aus dem Bioreaktor
14| Energieverbrauch des Campus Jülich optimieren
16| „Eine große Hilfestellung für Flutopfer“
20| Von der ersten Skizze zu den Blumen in der Vase
22|Wie schläft es sich im All, Herr Maurer?
24| Expedition Arktis
28| Eine Frage, zwei Antworten
30| Der schönste Arbeitsplatz der Welt
32| Im Einklang
36| Ein Vorgeschmack auf die echte Arbeitswelt
38| Den Rätseln des Universums auf der Spur
40| Auf Umwegen in die Spitzenforschung
42| Klappe FH Aachen, die erste … Kamera läuft!
44| Auszeit
46| „Fotografie öffnet Türen zu Parallelwelten“
50| Es gibt viel zu tun
52| Durch-Blick
54| Weichen stellen für einen ganz besonderen Job
58| Souta, Iver und der Wind
60| Die FH Aachen ist systemakkreditiert
61| Der Vulkan
62| Kopfnuss, Impressum
Werkstatt Zukunft - Die FH Aachen versteht sich als interdisziplinäre Ideenschmiede
04| Aufbruch ins Ungewisse
08| Mit Altpapierresten aus der Energiekrise
14| Mehr Power für die Energiewende
20| Pfadfinder im Datendschungel
23| Ein historischer Schritt
24| Gemeinsam vorwärts
30| Für eine gerechte Hochschule. Für alle.
32| Der grüne Reiter
34| Vom Flugsimulator bis zum Roboter
36| Unsere Azubis sind top!
38| WIR sind ein Sportteam!
40| Effizient und sicher: Der Bergbau der Zukunft
46| Mit Sonnenlicht zu sauberem Trinkwasser
48| Neue Brandmeldeanlage für den Dom zu Aachen
50| Auszeichnung für außergewöhnliches Engagement
52| Neue Ideen für Schloss Lichtenburg
55| Kopfnuss
56| One-Man-Show
60| Kämpferin für das Schöne
61| Ein charmanter Diplomat
62| Teamplay für die Zukunft
63| Impressum