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Regenerative Energiequellen
(1978)
Synthesis of derivatives of the peptide sequence L-pyroglutamyl-L-phenylalanyl-L-aspartyl-glycyl-L-lysyl-glycyl-glycyl-glycine as the antigenic determinant representing the N-terminal non-helical region of the α-2-chain of rabbit skin collagen, and conjugation to two different polypeptide carriers, are described.
Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay.
With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these.
Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons.
Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4.
These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia.
Band structure in ¹⁹⁴ Au
(1979)
New isomers in ¹⁴² Sm
(1979)
New isomeric state in ¹⁴⁵ Eu
(1979)
In-beam study of ¹⁴⁵ Gd
(1979)
High-spin states in ¹⁸⁰ Os
(1979)
Numerische Berechnung des Tritium-Verhaltens von Kugelhaufenreaktoren am Beispiel des AVR-Reaktors
(1979)
Evaluation of Particle Size Distributions by Means of Particle Counters / Fißan, H. J. ; Helsper, C.
(1979)
Regenerative Energiequellen
(1979)
Zur Synthese der Hühnerinsulin-A-Kette, I : Darstellung der Fragmente A1–8, A9–15, A1–7 und A8–15
(1979)
Synthese der Sequenz 71—86 des Humanproinsulins, III : Synthese über die Fragmente 71—78 und 79—86
(1979)
Akzeptorionen in BaTiO3 und SrTiO3 und ihre Auswirkungen auf die Eigenschaften von Titanatkeramiken
(1980)
BaTiO3 dotiert mit 3d-Ionen: Valenzen, Leerstellen und ihre Auswirkungen. Hagemann, H. J.; Ihrig, H.
(1980)
New isomers in ¹⁴² Sm
(1980)
Isomeric states in ¹³⁴ Ba
(1980)
High-spin states in ¹³³ La
(1980)
Isomeric states in ¹³⁴ Ba
(1980)
New isomeric state in ¹⁴⁴ Eu
(1980)