Refine
Author
- Manfred Staat (16)
- Alexander Ferrein (12)
- Michael Josef Schöning (12)
- Nils Tippkötter (11)
- Daniel B. Bung (10)
- Daniel Valero (10)
- Christoph Butenweg (6)
- Gerald Steinbauer (6)
- Kilian Wegmann (5)
- Lars-Peter Müller (5)
- Michael Hackl (5)
- Ralf Frotscher (5)
- Torsten Wagner (5)
- Andreas Bitz (4)
- Andreas Gebhardt (4)
- Arshak Poghossian (4)
- Bernd Dachwald (4)
- Frank Janser (4)
- Harald Funke (4)
- Jan Keinz (4)
- Nico Scheer (4)
- Stephan Kallweit (4)
- Adrian C. Orifici (3)
- Akbar A. Khatibi (3)
- Alexander Jung (3)
- Aysegül Temiz Artmann (3)
- Eugen Neu (3)
- Holger Heuermann (3)
- Ilya Digel (3)
- Kirsten Albracht (3)
- Lena Altherr (3)
- Michael Keusgen (3)
- Nils Hojdis (3)
- Robert Scheidweiler (3)
- S. Möhring (3)
- Sebastian Reuter (3)
- Stefan Schiffer (3)
- Stephan Bialonski (3)
- T. Hering (3)
- Tim Niemueller (3)
- Tobias Weber (3)
- Anis Haj Ayed (2)
- Aroj Bhattarai (2)
- Bernd Döring (2)
- Brent Stucker (2)
- Carmen Leicht-Scholten (2)
- Chunsheng Wu (2)
- Elisabeth Paulßen (2)
- Frank Michaux (2)
- Gerhard Artmann (2)
- Gerhard Lakemeyer (2)
- Gözde Dursun (2)
- H. Wulfhorst (2)
- Harald Rieper (2)
- Huschyar Al-Kaidy (2)
- Isabel Kuperjans (2)
- J. Roth (2)
- Johannes Alexander König (2)
- Karsten Kusterer (2)
- Ko-Ichiro Miyamoto (2)
- Laurent Salphati (2)
- Linda Steuer-Dankert (2)
- M. Oertel (2)
- Mark E. Ladd (2)
- Markus Dahmen (2)
- Martin Wolf (2)
- Matthias Goßmann (2)
- Minh Tuan Duong (2)
- Miro Duhovic (2)
- Ngoc Trinh Tran (2)
- Patrick Wagner (2)
- Peter F. Pelz (2)
- Peter Linder (2)
- R. Ulber (2)
- Sabina Jeschke (2)
- Simone Krafft (2)
- Stephan Orzada (2)
- Stephanie Lucina Kahmann (2)
- Sven Klinkel (2)
- Tatsuo Yoshinobu (2)
- Thanh Ngoc Tran (2)
- Thomas Bronder (2)
- Thomas Harzheim (2)
- Thomas Mang (2)
- Thorsten Ederer (2)
- Walter van Laack (2)
- Xiaoyan Chu (2)
- A. Duwe (1)
- A. Hoellig (1)
- A. Levers (1)
- A. Offenhäusser (1)
- A. Penna (1)
- A. Saparbekova (1)
- A. Schmidt-Trucksäss (1)
- A. Szumski (1)
- A. Yakushenko (1)
- A. Yeshibaev (1)
- Achim Stephan (1)
- Adam B. (1)
- Ajay B. Harish (1)
- Albert Zündorf (1)
- Alessandro Fasse (1)
- Alessandro Peloni (1)
- Alexander Bartz (1)
- Ali Pookhalil (1)
- Andre Schieffer (1)
- Andreas Bernecker (1)
- Andreas Fischbach (1)
- André Nursinski-Stolberg (1)
- Angela Niedermeyer (1)
- Angelo Infantino (1)
- Anja Rode (1)
- Anke Fissabre (1)
- Anna Bouffier (1)
- Anna Droszez (1)
- Anna-Maria Duwe (1)
- Ansgar Heidecker (1)
- Anton Greeff (1)
- Ariane Wilson (1)
- Arie Koster (1)
- Arnau Bayon (1)
- Atsushi Horikawa (1)
- Avantika Barve (1)
- B. Buecking (1)
- B. Conings (1)
- B. Eissfeller (1)
- B. Holtschoppen (1)
- B. M. Crookston (1)
- B. Wolfrum (1)
- B. van Grinsven (1)
- B. van Wulfen (1)
- Bastian Hoeveler (1)
- Bei Zhou (1)
- Bernd Markert (1)
- Bernhard Hoffschmidt (1)
- Bixia Chen (1)
- Bjoern Braunstein (1)
- Bodo Kraft (1)
- Britta Holtschoppen (1)
- C. Capitain (1)
- C. Conzen (1)
- C. Kendrick (1)
- C. Koch (1)
- C. Metzger-Boddien (1)
- C. Popescu (1)
- C. Rieke (1)
- C. Rösch (1)
- C. Sinke (1)
- C. Thomé (1)
- C. Wiebusch (1)
- C. Zetzsche (1)
- C. Ziegler (1)
- C.M. Müller-Renno (1)
- Carla Recker (1)
- Carolin Hoft (1)
- Caroline Lange (1)
- Carsten Braun (1)
- Carsten Harlaß (1)
- Carsten Svaneborg (1)
- Christian Czarnecki (1)
- Christian Geier (1)
- Christian Grimm (1)
- Christian Ries (1)
- Christoph Schopp (1)
- Christopher Maier (1)
- Clara Andonian (1)
- Clemens Espe (1)
- Clemens Mühlbacher (1)
- Cornelia Hoehr (1)
- Cristiano José Teixeira Boura (1)
- D. Blandfort (1)
- D. D’Ayala (1)
- D. Eliseev (1)
- D. Eschbach (1)
- D. Heinen (1)
- D. Heinze (1)
- D. Otten (1)
- D. Pyschny (1)
- D. S. Correa (1)
- Damir Simic (1)
- Daniel Ewert (1)
- Daniel L. Belavy (1)
- Danita Muanghong (1)
- David A. Caron (1)
- David Gomez-Zepeda (1)
- Denise Molinnus (1)
- Dirk Abel (1)
- Dominik Stollenwerk (1)
- Domiziano Mostacci (1)
- E. M. Hamad (1)
- E. Vintzileou (1)
- Eberhard Triesch (1)
- Eline K. Vos (1)
- Elke Bosse (1)
- Engelbert Plescher (1)
- Enno Dülberg (1)
- Esaie Pierre (1)
- Eulalie Joelle Ngamga (1)
- F. Eber (1)
- F. Geiger (1)
- F. Kratz (1)
- F. Scholz (1)
- F. da Porto (1)
- Felix Finger (1)
- Felix Hüning (1)
- Felix Schneider (1)
- Francisco José Vallés-Morán (1)
- Franz Fleck (1)
- Fred Lisdat (1)
- Frederik Werner (1)
- G. Ameres (1)
- G. E. Stavroulakis (1)
- G. Gradl-Dietsch (1)
- G.A. Schubert (1)
- Georgios Eleftherios Stavroulakis (1)
- Gerd-Peter Brüggemann (1)
- Gereon Elbers (1)
- Gerhard Dikta (1)
- Gero Francke (1)
- Gert-Peter Bruggemann (1)
- Gert-Peter Brüggemann (1)
- Ghassem Amoabediny (1)
- Gregor Huber (1)
- H. Clusmann (1)
- H. Degee (1)
- H. G. Matthies (1)
- H. Gliemann (1)
- H. Niedermeier (1)
- H.-C. Pape (1)
- H.-G. Boyen (1)
- Hadi Tabesh (1)
- Handan He (1)
- Hanno Scharr (1)
- Hanns-Alexander Dietrich (1)
- Hans Kemper (1)
- Hans-Wilhelm Höfken (1)
- Harald H. Quick (1)
- Harald Kleine (1)
- Heike Matcha (1)
- Heiko Engemann (1)
- Helene Wulfhorst (1)
- Herbert Olivier (1)
- Hermann G. Matthies (1)
- Holger Kantz (1)
- Holger Klose (1)
- Holger S. Willenberg (1)
- Hossein Ali Karimi-Varzaneh (1)
- Ian D. Wilson (1)
- Isabel Beckenbach (1)
- Ivan Greguric (1)
- J. Clemens (1)
- J. Gilbert (1)
- J. Heikkinen (1)
- J. Klouda (1)
- J. Matos (1)
- J. Mikucki (1)
- J. Schütz (1)
- J. Thieringer (1)
- J. Warmer (1)
- Jaap H. van Dieen (1)
- Jacqueline McLeod (1)
- Jan Thimo Grundmann (1)
- Jan-Christoph Arent (1)
- Jan-Peter Goldmann (1)
- Jan-Steffen Hötter (1)
- Jane J. Tellis (1)
- Jasmine Roth (1)
- Jeevan Kunta (1)
- Jens Biele (1)
- Jin Zhang (1)
- Jocelyn Yabut (1)
- Jodie Pang (1)
- Johanna Roussel (1)
- Johannes Kochs (1)
- Johannes M. Balvers (1)
- Johannes Maurer (1)
- Johannes Merseburg (1)
- Johannes Schiffels (1)
- Jorge Lacayo (1)
- Josef Schleupen (1)
- Julia Kessler (1)
- Julia Kowalski (1)
- Julia Schloen (1)
- Juliane Jungk (1)
- Julio Arreola (1)
- Junichi Kitajima (1)
- Jörg Becker (1)
- Jürgen Kurths (1)
- K. Beyer (1)
- K. Forkmann (1)
- K. Haenen (1)
- K. Helbing (1)
- K. Hemmila (1)
- K. Konstantinidis (1)
- K. Sartayeva (1)
- K. Schill (1)
- K. Schmidt (1)
- Kai Kuthan (1)
- Karen DiLoreto (1)
- Karsten H. Wrede (1)
- Katharina Kasper (1)
- Katharina Mayer (1)
- Khosrow Mottaghy (1)
- Kiritharan Gangatharan (1)
- Klaus Lehnertz (1)
- Konstantin Kotliar (1)
- Konstantin Mykoniou (1)
- Kunio Okada (1)
- L. A. Dalguer (1)
- L. Akynova (1)
- L. Michiels (1)
- L. Sorrentino (1)
- Lars Breuer (1)
- Lea Rausch (1)
- Liangfu Chen (1)
- Loic Laplanche (1)
- Luis A. Dalguer (1)
- Lukas Münch (1)
- Lukas Schwab (1)
- M. Ameloot (1)
- M. Baier (1)
- M. Engel (1)
- M. Feldmann (1)
- M. Fuest (1)
- M. Gams (1)
- M. Giesen (1)
- M. Gratz (1)
- M. Hannig (1)
- M. Keusgen (1)
- M. Knobe (1)
- M. Mueller (1)
- M. S. Murib (1)
- M. Sadenova (1)
- M. Sansom (1)
- M. Schmidt (1)
- M. Seiz (1)
- M. Strobel (1)
- M. Turaliyeva (1)
- M. Weiss (1)
- M.A. Brockmann (1)
- Maciej J. Zamek-Gliszczynski (1)
- Malte Mätzkow (1)
- Manfred Wilhelm (1)
- Marc Bläsing (1)
- Marc Havermann (1)
- Marc Schlamann (1)
- Marc Schreiber (1)
- Marco Feldmann (1)
- Marcus Hallmann (1)
- Maren Sorich (1)
- Marie-Claude Menet (1)
- Mario Mezler (1)
- Mark J. van Uden (1)
- Marko Marinkovic (1)
- Marko Marinković (1)
- Marko Schuba (1)
- Markus Fredebeul-Krein (1)
- Markus Raue (1)
- Markus Schlotterer (1)
- Marlena Palomar Durán (1)
- Marnix C. Maas (1)
- Martin Pieper (1)
- Martin Reißel (1)
- Martin Tieves (1)
- Masahide Kazari (1)
- Masaki Nakagawa (1)
- Mathias Eggert (1)
- Matteo Ceriotti (1)
- Matthias Bäcker (1)
- Matthias Steinhorst (1)
- Max Leingartner (1)
- Maximilian Sanno (1)
- Mehdi Behbahani (1)
- Melanie Kolditz (1)
- Michael Gottschalk (1)
- Michael Marso (1)
- Michael Müller (1)
- Michael Prantner (1)
- Michael Trinczek (1)
- Michel Marso (1)
- Minami Abe (1)
- Miriam Barnat (1)
- Miriam W. Lagemaat (1)
- Mohsen Bagheri (1)
- Moritz Nabel (1)
- N. Mojsilovic (1)
- N. Umanskaya (1)
- N. Y. Adly (1)
- Nicolae Balc (1)
- Nicolai David Jablonowski (1)
- Nigel A. Lengkeek (1)
- Nils B. Kerpen (1)
- Nils Beckmann (1)
- Norbert Marwan (1)
- O. Funke (1)
- O. Jurca (1)
- O. Weichold (1)
- Oliver Kraff (1)
- Oliver Langer (1)
- Oliver Wrede (1)
- P. Amparo López-Jiménez (1)
- P. Hendrick (1)
- P. Kaul (1)
- P. Wagner (1)
- Patrick Delfmann (1)
- Paul A. Pellegrini (1)
- Paul Schaffer (1)
- Peter Wriggers (1)
- Petra Siegert (1)
- Philipp Dammann (1)
- Philipp Leise (1)
- Philipp Pöttgen (1)
- Philippe Renault (1)
- Pieter-Paul A. Vergroesen (1)
- R. Abildayeva (1)
- R. Carleer (1)
- R. Elsing (1)
- R. Förstner (1)
- R. Garay (1)
- R. Hoffmann (1)
- R. Ogden (1)
- R. Stopforth (1)
- R. Thoelen (1)
- R. Tucho (1)
- R.M. Lawson (1)
- Rafael Garcia-Bartual (1)
- Rainer Kling (1)
- Ralf Everaers (1)
- Robert Walenta (1)
- Robin Bayer (1)
- Roland Ulber (1)
- Ron Weiner (1)
- S. Börner (1)
- S. E. R. Bilatto (1)
- S. Ghosch (1)
- S. Hiecker (1)
- S. Klinkel (1)
- S. Lagomarsino (1)
- S. Lu (1)
- S. Macht (1)
- S. Plate (1)
- S. Resalati (1)
- S. Scheja (1)
- S. Trautmann (1)
- S. Tulaczyk (1)
- S. Zierke (1)
- Sarah Schöngarth (1)
- Sergey Churilov (1)
- Shahriar Dantism (1)
- Shannon Dallas (1)
- Shoko Takenaga (1)
- Siegfried Jahnke (1)
- Simon Broenner (1)
- Sreelakshmy Rajan (1)
- Stefan Niederwestberg (1)
- Stefanie D. Moorthi (1)
- Stephan Ulamec (1)
- Stephanie Chasseigneaux (1)
- Stephanie Kahmann (1)
- Stravros Vassos (1)
- Sylvester Abanteriba (1)
- Sören Seebold (1)
- T. Booysen (1)
- T. Kubalski (1)
- T. Leschinger (1)
- T. Reineking (1)
- Takuya Sato (1)
- Tatjana Damm (1)
- Teppei Hojo (1)
- Theodor Doll (1)
- Thivaharan Albin (1)
- Thomas Hering (1)
- Thomas Hombach (1)
- Thomas Kubalski (1)
- Thomas Wanek (1)
- Thomas Wilke (1)
- Thorsten Selmer (1)
- Tim Niemüller (1)
- Timo Doll (1)
- Tobias Kollmann (1)
- Tobias Neumann (1)
- Tobias Schoemberg (1)
- Tom W. J. Scheenen (1)
- Tony Pereira (1)
- Torsten Schlurmann (1)
- Tycho Heimbach (1)
- U. Bestmann (1)
- U. Bingel (1)
- U. Epple (1)
- U. Naumann (1)
- Ulf Herrmann (1)
- Ulf Lorenz (1)
- Ulrich Gräser (1)
- Ulrich Schurr (1)
- Ulrich Sure (1)
- Ulrich W. Scherer (1)
- Ulrike Feudel (1)
- V. Bosiljkov (1)
- V. Reger (1)
- Van So Le (1)
- Vincent Breukels (1)
- W. Albanna (1)
- W. S. Yeap (1)
- W. Vilser (1)
- W. de Ceuninck (1)
- Wen Lin (1)
- Wenkui Li (1)
- Wolfgang Vornholt (1)
- Wolfram Müller (1)
- Xavier Declèves (1)
- Xiaolin Zhang (1)
- Y. Eurlings (1)
- Zh. E. Aimenova (1)
- Ziyi Wu (1)
- А. А. Eshibaev (1)
Year of publication
- 2016 (154) (remove)
Document Type
- Article (78)
- Conference Proceeding (65)
- Part of a Book (7)
- Book (2)
- Doctoral Thesis (1)
- Report (1)
Language
- English (154) (remove)
Keywords
- Technical Operations Research (2)
- Additive Manufacturing (1)
- Annulus Fibrosus (1)
- Assessment (1)
- Asymptotic efficiency (1)
- Bacillus atrophaeus (1)
- Balance (1)
- Balanced hypergraph (1)
- Building Systems (1)
- Business Simulations (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- CellDrum (1)
- Censored data (1)
- Co-managed care (1)
- Collaborative robot (1)
- Computational biomechanics (1)
- Controller Parameter (1)
- DNA biosensor (1)
- Disc Degeneration (1)
Institute
- Fachbereich Medizintechnik und Technomathematik (43)
- IfB - Institut für Bioengineering (29)
- Fachbereich Chemie und Biotechnologie (26)
- Fachbereich Elektrotechnik und Informationstechnik (26)
- Fachbereich Luft- und Raumfahrttechnik (21)
- Fachbereich Bauingenieurwesen (13)
- INB - Institut für Nano- und Biotechnologien (13)
- Fachbereich Maschinenbau und Mechatronik (12)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (11)
- Fachbereich Energietechnik (10)
- Institut fuer Angewandte Polymerchemie (5)
- ECSM European Center for Sustainable Mobility (4)
- Fachbereich Wirtschaftswissenschaften (3)
- Nowum-Energy (3)
- Fachbereich Architektur (2)
- Fachbereich Gestaltung (1)
- Solar-Institut Jülich (1)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (1)
NVS123 is a poorly water-soluble protease 56 inhibitor in clinical development. Data from in vitro hepatocyte studies suggested that NVS123 is mainly metabolized by CYP3A4. As a consequence of limited solubility, NVS123 therapeutic plasma exposures could not be achieved even with high doses and optimized formulations. One approach to overcome NVS123 developability issues was to increase plasma exposure by coadministrating it with an inhibitor of CYP3A4 such as ritonavir. A clinical boost effect was predicted by using physiologically based pharmacokinetic (PBPK) modeling. However, initial boost predictions lacked sufficient confidence because a key parameter, fraction of drug metabolized by CYP3A4 (ƒₘCYP3A4), could not be estimated with accuracy on account of disconnects between in vitro and in vivo preclinical data. To accurately estimate ƒₘCYP3A4 in human, an in vivo boost effect study was conducted using CYP3A4-humanized mouse model which showed a 33- to 56-fold exposure boost effect. Using a top-down approach, human ƒₘCYP3A4 for NVS123 was estimated to be very high and included in the human PBPK modeling to support subsequent clinical study design. The combined use of the in vivo boost study in CYP3A4-humanized mouse model mice along with PBPK modeling accurately predicted the clinical outcome and identified a significant NVS123 exposure boost (∼42-fold increase) with ritonavir.