Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage – preliminary findings from an observational cohort study
- Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.
| Verfasserangaben: | Felix Neumaier, Miriam Weiss, Michael Veldeman, Konstantin KotliarORCiD, Martin Wiesmann, Henna Schulze-Steinen, Anke Höllig, Hans Clusmann, Gerrit Alexander Schubert, Walid Albanna |
|---|---|
| DOI: | https://doi.org/10.1016/j.clineuro.2021.106870 |
| ISSN: | 0303-8467 |
| Titel des übergeordneten Werkes (Englisch): | Clinical Neurology and Neurosurgery |
| Verlag: | Elsevier |
| Verlagsort: | Amsterdam |
| Dokumentart: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Erscheinungsjahr: | 2021 |
| Datum der Publikation (Server): | 18.08.2021 |
| Freies Schlagwort / Tag: | constructive alignment; examination; long-term retention; multimodal; practical learning |
| Jahrgang: | 208 |
| Ausgabe / Heft: | Article No.: 106870 |
| Link: | https://doi.org/10.1016/j.clineuro.2021.106870 |
| Zugriffsart: | bezahl |
| Fachbereiche und Einrichtungen: | FH Aachen / Fachbereich Medizintechnik und Technomathematik |
| FH Aachen / IfB - Institut für Bioengineering | |
| collections: | Verlag / Elsevier |
