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Genetically Humanized Animal Models
- Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
| Verfasserangaben: | K. Samuelsson, Nico ScheerORCiD, I. Wilson, C.R. Wolf, C.J. Henderson |
|---|---|
| DOI: | https://doi.org/10.1016/B978-0-12-409547-2.12376-5 |
| ISBN: | 978-0-12-803201-5 |
| Titel des übergeordneten Werkes (Englisch): | Comprehensive Medicinal Chemistry III. 3rd Edition |
| Verlag: | Elsevier |
| Verlagsort: | Saint Louis |
| Herausgeber: | Samuel Chackalamannil |
| Dokumentart: | Teil eines Buches (Kapitel) |
| Sprache: | Englisch |
| Erscheinungsjahr: | 2017 |
| Datum der Publikation (Server): | 08.04.2019 |
| Freies Schlagwort / Tag: | Chimeric liver-humanized mice; Drug distribution; Drug metabolism; Knockout mice; Toxicology |
| Erste Seite: | 130 |
| Letzte Seite: | 149 |
| Link: | https://doi.org/10.1016/B978-0-12-409547-2.12376-5 |
| Zugriffsart: | bezahl |
| Fachbereiche und Einrichtungen: | FH Aachen / Fachbereich Chemie und Biotechnologie |
| collections: | Verlag / Elsevier |
