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Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae

  • The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions. Subtilases are divided in several groups and especially subtilisins are of interest as they are used in various industrial sectors. Therefore, we searched for new subtilisin sequences of the family Bacillaceae using a data mining approach. The obtained 1,400 sequences were phylogenetically classified in the context of the subtilase family. This required an updated comprehensive overview of the different groups within this family. To fill this gap, we conducted a phylogenetic survey of the S8 family with characterised holotypes derived from the MEROPS database. The analysis revealed the presence of eight previously uncharacterised groups and 13 subgroups within the S8 family. The sequences that emerged from the data mining with the set filter parameters were mainly assigned to the subtilisin subgroups of true subtilisins, high-alkaline subtilisins, and phylogenetically intermediate subtilisins and represent an excellent source for new subtilisin candidates.

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Author:Fabian FalkenbergORCiD, Michael Bott, Johannes BongaertsORCiD, Petra SiegertORCiD
Parent Title (English):Frontiers in Microbiology
Place of publication:Lausanne
Document Type:Article
Year of Completion:2022
Date of first Publication:2022/09/26
Date of the Publication (Server):2023/02/16
Length:Artikel 13:1017978
Institutes:FH Aachen / Fachbereich Chemie und Biotechnologie
FH Aachen / INB - Institut für Nano- und Biotechnologien
collections:Verlag / Frontiers
Open Access / Gold
Licence (German):License LogoCreative Commons - Namensnennung