Towards theranostics of rheumatoid arthritis: 1H/19F imaging of non-steroidal anti-inflammatory drugs in hand and wrist at 7 Tesla
- We have developed a double-tuned ¹H/¹⁹F birdcage resonator dedicated for hand and wrist imaging at 7 T to locally image non-steroidal anti-inflammatory drugs (NSAID) such as 2-{[3-(Trifluoromethyl) phenyl]amino}benzoic acid. The preliminary in vivo images acquired by the double-tuned ¹H/¹⁹F birdcage resonator demonstrate the feasibility for ¹H/¹⁹F hand- and wrist-imaging at 7 T. While the diagnostic quality of the coil needs to be assessed in patients with inflammatory rheumatoid disease, first ¹⁹F images of the NSAID are encouraging, and point towards the prospect of applying ¹⁹F-MRI to visualize and quantify the concentration of therapeutically-active compound at the sites of inflammation.
| Author: | Helmar Waiczies, André Kühne, Lukas Winter, Tobias Frauenrath, Werner Hoffmann, Bernd Ittermann, Sonia Waiczies, Thoralf Niendorf |
|---|---|
| ISSN: | 1545-4428 |
| Parent Title (English): | 2013 ISMRM Annual Meeting Proceedings |
| Document Type: | Conference: Meeting Abstract |
| Language: | English |
| Year of Completion: | 2013 |
| Date of the Publication (Server): | 2024/06/26 |
| Article Number: | Abstract #3504 |
| Note: | ISMRM 21st Annual Meeting & Exhibition, 20-26 April 2013, Salt Lake City, Utah, USA |
| Link: | https://ismrm.gitlab.io/2013/3504.html |
| Zugriffsart: | weltweit |
| Institutes: | FH Aachen / Fachbereich Elektrotechnik und Informationstechnik |
