Synthesis of 197m/gHg labelled gold nanoparticles for targeted radionuclide therapy
- Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).
Author: | Philipp Droop, Shaohuang Chen, Melissa J. Radford, Elisabeth PaulßenORCiD, Byron D. Gates, Raymond M. Reilly, Valery Radchenko, Cornelia Hoehr |
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DOI: | https://doi.org/10.1515/ract-2023-0144 |
ISSN: | 2193-3405 |
Parent Title (English): | Radiochimica Acta |
Publisher: | De Gruyter |
Place of publication: | Berlin [u.a.] |
Document Type: | Article |
Language: | English |
Year of Completion: | 2023 |
Date of first Publication: | 2023/07/28 |
Tag: | Meitner-Auger-electron (MAE); Targeted radionuclide therapy (TRT) 197m/gHg; Gold nanoparticle (AuNP) |
Volume: | 111 |
Issue: | 10 |
First Page: | 773 |
Last Page: | 779 |
Link: | https://www.degruyter.com/document/doi/10.1515/ract-2023-0144/html |
Link: | https://research.tudelft.nl/files/157442942/10.1515_ract_2023_0144.pdf |
Zugriffsart: | bezahl |
Zugriffsart: | weltweit |
Institutes: | FH Aachen / Fachbereich Elektrotechnik und Informationstechnik |
collections: | Verlag / De Gruyter |