How to determine the permeability for cement infiltration into osteoporotic cancellous bone

  • Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm4/N.s) reduced to approximately 63% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice.

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Metadaten
Author:Gamal Baroud, J.Z. Wu, Marc Bohner, Stefan Sponagel, Thomas Steffen
DOI:https://doi.org/10.21269/97
ISSN:1350-4533
Parent Title (English):Medical Engineering & Physics. 25 (2003), H. 4
Document Type:Article
Language:English
Year of Completion:2003
Publishing Institution:Fachhochschule Aachen
Tag:Vertebroplastie
Analysis; Cement infiltration; Experiment; Osteoporosis; Permeability; Vertebroplasty; Viscous flow
GND Keyword:Osteoporose; Permeabilität; Viskose Strömung; Viskosität
First Page:283
Last Page:288
Link:http://dx.doi.org/10.1016/S1350-4533(02)00223-0
Zugriffsart:bezahl
Institutes:FH Aachen / Fachbereich Medizintechnik und Technomathematik
FH Aachen / IfB - Institut für Bioengineering
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 60 Technik / 600 Technik, Technologie