Refine
Year of publication
- 2019 (42) (remove)
Institute
Has Fulltext
- no (42)
Document Type
- Article (26)
- Conference Proceeding (12)
- Book (1)
- Part of a Book (1)
- Patent (1)
- Talk (1)
Keywords
- Achilles tendon (1)
- Architectural gear ratio (1)
- Assistive technology (1)
- Automatic control (1)
- Force (1)
- Human-Computer interaction (1)
- Iterative learning control (1)
- Knee (1)
- Load modeling (1)
- Rehabilitation engineering (1)
- Running (1)
- Stiffness (1)
- Tendon properties (1)
- Training (1)
- responsive space (1)
- small solar system body characterisation (1)
- small spacecraft asteroid lander (1)
- small spacecraft solar sail (1)
- system engineering (1)
Is part of the Bibliography
- no (42)
Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).