Refine
Year of publication
Institute
- Fachbereich Medizintechnik und Technomathematik (522) (remove)
Language
- English (522) (remove)
Document Type
- Article (384)
- Conference Proceeding (95)
- Part of a Book (22)
- Book (9)
- Doctoral Thesis (3)
- Other (3)
- Patent (3)
- Lecture (2)
- Talk (1)
Keywords
- Finite-Elemente-Methode (12)
- Einspielen <Werkstoff> (10)
- FEM (6)
- Limit analysis (6)
- Shakedown analysis (6)
- shakedown analysis (6)
- Clusterion (5)
- Air purification (4)
- Hämoglobin (4)
- Lipopolysaccharide (4)
- Luftreiniger (4)
- Plasmacluster ion technology (4)
- Raumluft (4)
- limit analysis (4)
- CellDrum (3)
- Einspielanalyse (3)
- Kohlenstofffaser (3)
- Shakedown (3)
- Sonde (3)
- Technische Mechanik (3)
- Traglastanalyse (3)
- lipopolysaccharides (3)
- shakedown (3)
- Analytischer Zulaessigkeitsnachweis (2)
- Biocomposites (2)
- Bruchmechanik (2)
- Einspiel-Analyse (2)
- Eisschicht (2)
- Erythrozyt (2)
- Fibroblast (2)
- Iterative learning control (2)
- Natural fibres (2)
- Pflanzenphysiologie (2)
- Pflanzenscanner (2)
- Polymer-matrix composites (2)
- Stickstoffmonoxid (2)
- Stiffness (2)
- Stress concentrations (2)
- Traglast (2)
- biopotential electrodes (2)
- carbonized rice husk (2)
- celldrum technology (2)
- damage (2)
- limit load (2)
- locomotion (2)
- muscle fascicle behavior (2)
- nanostructured carbonized plant parts (2)
- nanostrukturierte carbonisierte Pflanzenteile (2)
- nitric oxide gas (2)
- plant scanner (2)
- ratchetting (2)
- ultrasound (2)
- ultrasound imaging (2)
- Achilles tendon (1)
- Adaptive control (1)
- Adsorption (1)
- Ageing (1)
- AlterG (1)
- Alternating plasticity (1)
- Alzheimer's disease (1)
- Analysis (1)
- Anastomose (1)
- Anastomosis (1)
- Anastomotic leakage (1)
- Anatomy (1)
- Annulus Fibrosus (1)
- Architectural gear ratio (1)
- Assistive technology (1)
- Autofluoreszenzverfahren (1)
- Autolysis (1)
- Automatic control (1)
- Axialbelastung (1)
- Axially cracked pipe (1)
- Bacillus sp (1)
- Bacterial cellulose (1)
- Bakterien (1)
- Basis Reduktion (1)
- Basis reduction (1)
- Bicharakteristikenverfahren (1)
- Biomechanical simulation (1)
- Biomechanics (1)
- Biomechanik (1)
- Biomedizinische Technik (1)
- Bioreaktor (1)
- Biosolubilization (1)
- Bladder (1)
- Blutzellenlagerung (1)
- Bone quality and biomechanics (1)
- Bone sawing (1)
- Carbon sources (1)
- Cardiac myocytes (1)
- Cardiac tissue (1)
- Cell permeability (1)
- Cellular force (1)
- Cellulose nanostructure (1)
- Cement infiltration (1)
- Cementoblast (1)
- Chance constrained programming (1)
- Circular Dichroism (1)
- Coal (1)
- Coefficient of ocular rigidity (1)
- Compression (1)
- Computational biomechanics (1)
- Constitutive model (1)
- Contractile tension (1)
- Convex optimization (1)
- Corneo-scleral shell (1)
- Cost-effectiveness (1)
- Culture media (1)
- Damage mechanics theory (1)
- Dattel (1)
- Decomposition (1)
- Deformation (1)
- Dekontamination (1)
- Design-by-analysis (1)
- Differential tonometry (1)
- Disc Degeneration (1)
- Discontinuous fractures (1)
- Druckbeanspruchung (1)
- Druckbehälter (1)
- Druckbelastung (1)
- Druckgeräte (1)
- Drug simulation (1)
- Dry surfaces (1)
- EEG (1)
- ELISA (1)
- ES-FEM (1)
- Einspiel-Kriterium (1)
- Einspielen (1)
- Elastizität (1)
- Elastodynamik (1)
- Elastostatics (1)
- Electromechanical modeling (1)
- Elektrodynamik (1)
- End-to-end colorectal anastomosis (1)
- Endothelial cells (1)
- Endothelial dysfunction (1)
- Endothelzelle (1)
- Environmental impact (1)
- Enzyme-linked immunosorbent assay (1)
- Epithel (1)
- Evolution of damage (1)
- Exact Ilyushin yield surface (1)
- Experiment (1)
- Extension fracture (1)
- Extension strain criterion (1)
- External knee adduction moments (1)
- Eyeball (1)
- FGF23 (1)
- FS-FEM (1)
- Fehlerstellen (1)
- Festkörper (1)
- Finite element analysis (1)
- Finite element analysis (FEA) (1)
- Finite element method (1)
- Finite element modelling (1)
- First Order Reliabiblity Method (1)
- First-order reliability method (1)
- Fließgrenze (1)
- Force (1)
- Forces (1)
- Fracture configuration (1)
- Fracture simulation (1)
- Freeze–thaw process (1)
- Frequency adaption (1)
- Geriatric (1)
- Glaucoma (1)
- Global and local collapse (1)
- Grenzwertberechnung (1)
- Growth modelling (1)
- H2 (1)
- Haemodialysis (1)
- Handbike (1)
- Harnleiter (1)
- Heart tissue culture (1)
- Hemoglobin structure (1)
- Hip fractures (1)
- Hodgkin–Huxley models (1)
- Homogenization (1)
- Human-Computer interaction (1)
- Hydrodynamik (1)
- Hydrogel (1)
- Hydrogenotrophic methanogens (1)
- Hämoglobinstruktur (1)
- Impedance Spectroscopy (1)
- Induced pluripotent stem cells (1)
- Inotropic compounds (1)
- Intervertebral Disc (1)
- Intradiscal Pressure (1)
- Inverse dynamic problem (1)
- Inverse kinematic problem (1)
- Ion channels (1)
- Kinematics (1)
- Kinetics (1)
- Klotho (1)
- Knee (1)
- Knochen (1)
- Knochenbildung (1)
- Knochenchirugie (1)
- Knochendichte (1)
- Körpertemperatur (1)
- LPS (1)
- Lichtstreuungsbasierte Instrumente (1)
- Liver (1)
- Load modeling (1)
- Long COVID (1)
- Machine learning (1)
- Manipulated variables (1)
- Materialermüdung (1)
- Mechanical simulation (1)
- Mechanics (1)
- Mechanische Beanspruchung (1)
- Mechanotransduction (1)
- Medusomyces gisevi (1)
- Methane (1)
- Methanogenesis (1)
- Microbial adhesion (1)
- Microcirculation (1)
- Mild cognitive impairment (1)
- Mohr–Coulomb criterion (1)
- Multi-dimensional wave propagation (1)
- Multimode failure (1)
- Muscle (1)
- Muscle Fascicle (1)
- Muscle Force (1)
- Muscle fibers (1)
- Musculoskeletal model (1)
- Musculoskeletal system (1)
- Myocardial infarction and cardiac death (1)
- NONOate (1)
- Natriumhypochlorit (1)
- Niacin (1)
- Nichtlineare Gleichung (1)
- Nichtlineare Optimierung (1)
- Nichtlineare Welle (1)
- Nitric Oxide (1)
- Nitric Oxide Donor (1)
- Non-linear optimization (1)
- Non-parallel fissures (1)
- Nucleus Pulposus (1)
- Ocular blood flow (1)
- Organkultur (1)
- Osteoporose (1)
- Osteoporosis (1)
- PFM (1)
- PTH (1)
- Paralympic sport (1)
- Passive stretching (1)
- Pelvic floor dysfunction (1)
- Pelvic muscle (1)
- Permeability (1)
- Permeabilität (1)
- Peroxidase (1)
- Pflanzenstress (1)
- Pharmacology (1)
- Phosphate (1)
- Physiology (1)
- Plastizität (1)
- Post-COVID-19 syndrome (1)
- Pressure loaded crack-face (1)
- Pressure-volume relationship (1)
- Prevention (1)
- Progressive plastic deformation (1)
- Prophylaxis (1)
- Proteine (1)
- Proximal humerus fracture (1)
- Pulsations (1)
- RVA (1)
- Random variable (1)
- Ratcheting (1)
- Ratchetting (1)
- Recombinant activated protein C (1)
- Reconstruction (1)
- Red blood cell storage (1)
- Rehabilitation Technology and Prosthetics (1)
- Rehabilitation engineering (1)
- Reliability analysis (1)
- Reliability of structures (1)
- Retinal vessel analysis (1)
- Retinal vessels (1)
- Riboflavin (1)
- Robotic rehabilitation (1)
- Rohr (1)
- Rohrbruch (1)
- Rotator cuff (1)
- Running (1)
- S-FEM (1)
- Sampling methods (1)
- Schwammknochen (1)
- Sensitivity (1)
- Sepsis (1)
- Septic cardiomyopathy (1)
- Shakedown criterion (1)
- Simulation (1)
- Skeletal muscle (1)
- Sleep EEG (1)
- Small Aral Sea (1)
- Spleen (1)
- Stahl (1)
- Statics (1)
- Stochastic programming (1)
- Strukturanalyse (1)
- Surface microorganisms (1)
- Surgical Navigation and Robotics (1)
- Surgical staplers (1)
- Swabbing (1)
- Temperaturabhängigkeit (1)
- Tendon Rupture (1)
- Tendon properties (1)
- Tendons (1)
- Tension (1)
- Thiamine (1)
- Tissue Engineering (1)
- Training (1)
- Ultrasound (1)
- Uniaxial compression test (1)
- Ureter (1)
- Variable height stapler design (1)
- Vascular response (1)
- Vasomotions (1)
- Vertebroplastie (1)
- Vertebroplasty (1)
- Viscous flow (1)
- Viskose Strömung (1)
- Viskosität (1)
- Visual field asymmetry (1)
- Vitamin A (1)
- Vitamin B (1)
- Vitamin D (1)
- Wasserbrücke (1)
- Wasserstoffperoxid (1)
- Wellen (1)
- Wolff's Law (1)
- Wolffsches Gesetz (1)
- Wundheilung (1)
- Zug-Druck Belastung (1)
- achilles tendon (1)
- actin cytoskeleton (1)
- activated nanostructured carbon (1)
- adipose-derived stromal cells (ASCs) (1)
- adsorption (1)
- agility (1)
- aktivierte nanostrukturierte Kohlenstofffaser (1)
- alternierend Verformbarkeit (1)
- anaesthetic complications (1)
- anisotropy (1)
- aortic perfusion (1)
- aromatic amines (1)
- autofluorescence-based detection system (1)
- biaxial tensile experiment (1)
- bicharacteristics (1)
- biomechanics (1)
- bone density (1)
- bone structure (1)
- burst pressure (1)
- burst tests (1)
- cancellous bone (1)
- cardiomyocyte biomechanics (1)
- cell aerosolization (1)
- cell atomization (1)
- cerebral small vessel disease (1)
- chance constrained programming (1)
- cognitive impairment (1)
- community dwelling (1)
- computational fluid dynamics analysis (1)
- connective tissue (1)
- constitutive modeling (1)
- constructive alignment (1)
- contractile tension (1)
- correlation (1)
- cytosolic water diffusion (1)
- date palm tree (1)
- dental trauma (1)
- design-by-analysis (1)
- dialysis (1)
- difficult airway (1)
- direct method (1)
- distorted element (1)
- double-lumen tube intubation (1)
- drop jump (1)
- ecological structure (1)
- elastic solids (1)
- electromyography (1)
- endoluminal (1)
- energy absorption (1)
- energy dissipation (1)
- epithelization (1)
- examination (1)
- extracorporeal membrane oxygenation (1)
- fatigue analyses (1)
- finite element analysis (1)
- flaw (1)
- force generation (1)
- forehead EEG (1)
- fortschreitende plastische Deformation (1)
- gait (1)
- healthy aging (1)
- hemoglobin (1)
- hemoglobin dynamics (1)
- hiPS cardiomyocytes (1)
- high-intensity exercise (1)
- human dermal fibroblasts (1)
- humic acid (1)
- hydrogel (1)
- hyper-gravity (1)
- hyperelastic (1)
- hypo-gravity (1)
- impedance spectroscopy (1)
- in-ear EEG (1)
- intraclass correlation coefficient (1)
- kontraktile Spannung (1)
- konvexe Optimierung (1)
- light scattering analysis (1)
- lignite (1)
- limit and shakedown analysis (1)
- linear kinematic hardening (1)
- lipopolysaccharide (1)
- load limit (1)
- long-term retention (1)
- lower bound theorem (1)
- material shakedown (1)
- mechanical buffer (1)
- mechanical waves (1)
- metagenomics (1)
- microbial diversity (1)
- multimodal (1)
- muscle mechanics (1)
- naphtols (1)
- non-simplex S-FEM elements (1)
- nonlinear kinematic hardening (1)
- nonlinear optimization (1)
- nonlinear solids (1)
- nonlinear tensor constitutive equation (1)
- overload (1)
- parabolic flight (1)
- performance testing (1)
- phenols (1)
- physiology (1)
- pipes (1)
- plant stress (1)
- plasma generated ions (1)
- practical learning (1)
- prevention (1)
- probabilistic fracture mechanics (1)
- protein (1)
- psychosocial (1)
- rehabilitation (1)
- reliability (1)
- reliability analysis (1)
- reliability of structures (1)
- retinal microvasculature (1)
- retinal vessels (1)
- rhAPC (1)
- running (1)
- sEMG (1)
- sarcomere operating length (1)
- second-order reliability method (1)
- sensors (1)
- series elastic element behavior (1)
- shakedown analyses (1)
- shotgun sequencing (1)
- shoulder (1)
- simulation (1)
- smooth muscle contraction (1)
- sprint start (1)
- standard error of measurement (1)
- stiffness (1)
- stochastic programming (1)
- strain energy function (1)
- stretch reflex (1)
- stretch-shortening cycle (1)
- subsurface ice research (1)
- subsurface probe (1)
- surface modification (1)
- survival (1)
- tendon rupture (1)
- tension–torsion loading (1)
- test-retest reliability (1)
- thermal ratcheting (1)
- training simulator (1)
- tri-lineage differentiation (1)
- twin-fluid atomizer (1)
- ultrasonography (1)
- unloading (1)
- vessels (1)
- videolaryngoscopy (1)
- virgin passive (1)
- virtual reality (1)
- viscoelasticity (1)
- walking (1)
- walking gait (1)
- water bridge phenomenon (1)
- wound healing (1)
- yield stress (1)
Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here.
A new in vitro tool to investigate cardiac contractility under physiological mechanical conditions
(2019)
Purpose
Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena.
Methods
Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model.
Results
A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained.
Conclusions
The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.
A microscopic photometric method for measuring erythrocyte deformability. Artmann, Gerhard Michael
(1986)
A generalized shear-lag theory for fibres with variable radius is developed to analyse elastic fibre/matrix stress transfer. The theory accounts for the reinforcement of biological composites, such as soft tissue and bone tissue, as well as for the reinforcement of technical composite materials, such as fibre-reinforced polymers (FRP). The original shear-lag theory proposed by Cox in 1952 is generalized for fibres with variable radius and with symmetric and asymmetric ends. Analytical solutions are derived for the distribution of axial and interfacial shear stress in cylindrical and elliptical fibres, as well as conical and paraboloidal fibres with asymmetric ends. Additionally, the distribution of axial and interfacial shear stress for conical and paraboloidal fibres with symmetric ends are numerically predicted. The results are compared with solutions from axisymmetric finite element models. A parameter study is performed, to investigate the suitability of alternative fibre geometries for use in FRP.
A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa’s ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live.