Refine
Year of publication
- 2019 (387) (remove)
Institute
- FH Aachen (74)
- Fachbereich Medizintechnik und Technomathematik (71)
- IfB - Institut für Bioengineering (45)
- Fachbereich Elektrotechnik und Informationstechnik (44)
- Fachbereich Luft- und Raumfahrttechnik (44)
- Fachbereich Wirtschaftswissenschaften (35)
- Fachbereich Bauingenieurwesen (28)
- Fachbereich Energietechnik (27)
- Fachbereich Maschinenbau und Mechatronik (27)
- INB - Institut für Nano- und Biotechnologien (20)
Document Type
- Article (123)
- Conference Proceeding (94)
- Administrative publication (72)
- Part of a Book (43)
- Book (25)
- Other (9)
- Doctoral Thesis (5)
- Patent (5)
- Review (4)
- Conference: Meeting Abstract (2)
Keywords
- Amtliche Mitteilung (68)
- Bachelor (31)
- Master (29)
- Prüfungsordnung (29)
- Lesbare Fassung (28)
- Studien- und Prüfungsordnung (21)
- Änderungsordnung (20)
- Bauingenieurwesen (17)
- Elektrotechnik (8)
- Holzingenieurwesen (6)
Human induced pluripotent stem cells (hiPSCs) have shown to be promising in disease studies and drug screenings [1]. Cardiomyocytes derived from hiPSCs have been extensively investigated using patch-clamping and optical methods to compare their electromechanical behaviour relative to fully matured adult cells. Mathematical models can be used for translating findings on hiPSCCMs to adult cells [2] or to better understand the mechanisms of various ion channels when a drug is applied [3,4]. Paci et al. (2013) [3] developed the first model of hiPSC-CMs, which they later refined based on new data [3]. The model is based on iCells® (Fujifilm Cellular Dynamics, Inc. (FCDI), Madison WI, USA) but major differences among several cell lines and even within a single cell line have been found and motivate an approach for creating sample-specific models. We have developed an optimisation algorithm that parameterises the conductances (in S/F=Siemens/Farad) of the latest Paci et al. model (2018) [5] using current-voltage data obtained in individual patch-clamp experiments derived from an automated patch clamp system (Patchliner, Nanion Technologies GmbH, Munich).
The paper industry is the industry with the third highest energy consumption in the European Union. Using recycled paper instead of fresh fibers for papermaking is less energy consuming and saves resources. However, adhesive contaminants in recycled paper are particularly problematic since they reduce the quality of the resulting paper-product. To remove as many contaminants and at the same time obtain as many valuable fibres as possible, fine screening systems, consisting of multiple interconnected pressure screens, are used. Choosing the best configuration is a non-trivial task: The screens can be interconnected in several ways, and suitable screen designs as well as operational parameters have to be selected. Additionally, one has to face conflicting objectives. In this paper, we present an approach for the multi-criteria optimization of pressure screen systems based on Mixed-Integer Nonlinear Programming. We specifically focus on a clear representation of the trade-off between different objectives.
The optical performance of a 2-axis solar concentrator was simulated with the COMSOL Multiphysics® software. The concentrator consists of a mirror array, which was created using the application builder. The mirror facets are preconfigured to form a focal point. During tracking all mirrors are moved simultaneously in a coupled mode by 2 motors in two axes, in order to keep the system in focus with the moving sun. Optical errors on each reflecting surface were implemented in combination with the solar angular cone of ± 4.65 mrad. As a result, the intercept factor of solar radiation that is available to the receiver was calculated as a function of the transversal and longitudinal angles of incidence. In addition, the intensity distribution on the receiver plane was calculated as a function of the incidence angles.