Refine
Year of publication
Institute
- Fachbereich Medizintechnik und Technomathematik (1543)
- Fachbereich Wirtschaftswissenschaften (700)
- Fachbereich Elektrotechnik und Informationstechnik (629)
- Fachbereich Energietechnik (598)
- Fachbereich Chemie und Biotechnologie (588)
- INB - Institut für Nano- und Biotechnologien (524)
- Fachbereich Maschinenbau und Mechatronik (463)
- IfB - Institut für Bioengineering (427)
- Fachbereich Luft- und Raumfahrttechnik (367)
- Fachbereich Bauingenieurwesen (327)
Has Fulltext
- no (5514) (remove)
Language
Document Type
- Article (5514) (remove)
Keywords
- avalanche (5)
- Earthquake (4)
- LAPS (4)
- field-effect sensor (4)
- frequency mixing magnetic detection (4)
- CellDrum (3)
- Heparin (3)
- capacitive field-effect sensor (3)
- hydrogen peroxide (3)
- impedance spectroscopy (3)
Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.
Size unlimited markerless deletions by a transconjugative plasmid-system in Bacillus licheniformis
(2013)
Sisyphus wird Steiff
(2010)