Refine
Year of publication
Document Type
- Article (5464) (remove)
Language
Has Fulltext
- no (5464) (remove)
Keywords
- avalanche (5)
- Earthquake (4)
- LAPS (4)
- field-effect sensor (4)
- frequency mixing magnetic detection (4)
- CellDrum (3)
- Heparin (3)
- capacitive field-effect sensor (3)
- hydrogen peroxide (3)
- magnetic nanoparticles (3)
- snow (3)
- tobacco mosaic virus (TMV) (3)
- Bacillus atrophaeus (2)
- Chemometrics (2)
- Datenschutz (2)
- Datenschutzgrundverordnung (2)
- Drinfeld modules (2)
- Empirical process (2)
- Field-effect sensor (2)
- Goodness-of-fit test (2)
Institute
- Fachbereich Medizintechnik und Technomathematik (1531)
- Fachbereich Wirtschaftswissenschaften (683)
- Fachbereich Elektrotechnik und Informationstechnik (617)
- Fachbereich Energietechnik (597)
- Fachbereich Chemie und Biotechnologie (585)
- INB - Institut für Nano- und Biotechnologien (523)
- Fachbereich Maschinenbau und Mechatronik (463)
- IfB - Institut für Bioengineering (426)
- Fachbereich Luft- und Raumfahrttechnik (364)
- Fachbereich Bauingenieurwesen (324)
- Solar-Institut Jülich (105)
- Fachbereich Architektur (76)
- Fachbereich Gestaltung (55)
- ZHQ - Bereich Hochschuldidaktik und Evaluation (39)
- ECSM European Center for Sustainable Mobility (33)
- Nowum-Energy (28)
- Sonstiges (23)
- Institut fuer Angewandte Polymerchemie (20)
- Freshman Institute (18)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (15)
[⁶⁸Ga(DOTATATE)] has demonstrated its clinical usefulness. Both Fe³⁺ and Cu²⁺, potential contaminants in Gallium-68 generator eluent, substantially reduce the radiochemical (RC) yield of [⁶⁸Ga(DOTATATE)] if the metal/ligand ratio of 1:1 is exceeded. A variety of compounds were examined for their potential ability to reduce this effect. Most had no effect on RC yield. However, addition of phosphate diminished the influence of Fe³⁺ by likely forming an insoluble iron salt. Addition of ascorbic acid reduced Cu²⁺ and Fe³⁺ to Cu⁺ and Fe²⁺ respectively, both of which have limited impact on RC yields. At low ligand amounts (5 nmol DOTATATE), the addition of 30 nmol phosphate (0.19 mM) increased the tolerance of Fe3⁺ from 4 nmol to 10 nmol (0.06 mM), while the addition of ascorbic acid allowed high RC yields (>95%) in the presence of 40 nmol Fe³⁺ (0.25 mM) and 100 nmol Cu²⁺ (0.63 mM). The effect of ascorbic acid was highly pH-dependant, and gave optimal results at pH 3.