Refine
Year of publication
Document Type
- Article (3149)
- Conference Proceeding (1016)
- Part of a Book (184)
- Book (144)
- Doctoral Thesis (30)
- Patent (25)
- Other (9)
- Report (9)
- Preprint (4)
- Poster (3)
- Talk (3)
- Master's Thesis (2)
- Working Paper (2)
- Bachelor Thesis (1)
- Contribution to a Periodical (1)
- Habilitation (1)
Language
- English (4583) (remove)
Has Fulltext
- no (4583) (remove)
Keywords
- Gamification (6)
- avalanche (6)
- Earthquake (5)
- Enterprise Architecture (5)
- MINLP (5)
- solar sail (5)
- Diversity Management (4)
- Energy storage (4)
- Engineering optimization (4)
- LAPS (4)
- Natural language processing (4)
- Papierkunst (4)
- Power plants (4)
- Seismic design (4)
- field-effect sensor (4)
- frequency mixing magnetic detection (4)
- hydrogen (4)
- metal structure (4)
- snow (4)
- steel (4)
Institute
- Fachbereich Medizintechnik und Technomathematik (1545)
- Fachbereich Elektrotechnik und Informationstechnik (686)
- IfB - Institut für Bioengineering (560)
- Fachbereich Energietechnik (552)
- INB - Institut für Nano- und Biotechnologien (532)
- Fachbereich Chemie und Biotechnologie (522)
- Fachbereich Luft- und Raumfahrttechnik (463)
- Fachbereich Maschinenbau und Mechatronik (261)
- Fachbereich Wirtschaftswissenschaften (196)
- Solar-Institut Jülich (160)
- Fachbereich Bauingenieurwesen (146)
- ECSM European Center for Sustainable Mobility (75)
- MASKOR Institut für Mobile Autonome Systeme und Kognitive Robotik (62)
- Fachbereich Gestaltung (24)
- Nowum-Energy (24)
- Institut fuer Angewandte Polymerchemie (23)
- Sonstiges (21)
- Fachbereich Architektur (20)
- Freshman Institute (18)
- Kommission für Forschung und Entwicklung (18)
Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.