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Tumour cell death can be evaluated in the living mouse by externally measuring the rate of loss of tumour-bound DNA tracer. By sequentially labelling the tumour-bearing animals with ¹²⁵IUdR and ¹³¹IUdR 50 h apart, the average tumour cells at the time of the second injection are labelled by ¹²⁵IUdR and the euoxic tumour cells are specifically labelled with ¹³¹IUdR. Tumour treatment at this stage of labelling permits the observation of the reaction of euoxic cells and average tumour cells and finally yields data on hypoxic cells and thus on the oxygen enhancement ratio. This information adds to results from tumour control and growth delay.
With this technique effects were analysed of 60-Co γ-rays, cyclotron neutrons (E = 6 MeV), misonidazole (500 mg/kg body wt) and hyperthermia (42°C water-bath), or combinations of these.
Misonidazole (15 min before irradiation) altered the oxygen enhancement ratio by a factor of 1·5 for γ-rays and of 1·1 for neutrons; when evaluated from tumour-growth delay and TCD-50 misonidazole gave a dose modifying factor of 1·47 for γ-rays and of 1·2-1·3 for neutrons.
Based on percentage tumour regression 100 days after treatment, the enhancement ratio from hyperthermia (after irradiation) was 2·75 for γ-rays (at 10 Gray) and 2·2 for neutrons (at 3·2 Gray). For neutrons combined with misonidazole and hyperthermia the ratio was 2·4.
These results demonstrate that effects of neutron irradiation may be modified by electron-affinic substances and/or hyperthermia.
Band structure in ¹⁹⁴ Au
(1979)
New isomers in ¹⁴² Sm
(1979)
New isomeric state in ¹⁴⁵ Eu
(1979)
In-beam study of ¹⁴⁵ Gd
(1979)
High-spin states in ¹⁸⁰ Os
(1979)
Evaluation of Particle Size Distributions by Means of Particle Counters / Fißan, H. J. ; Helsper, C.
(1979)
New isomers in ¹⁴² Sm
(1980)
Isomeric states in ¹³⁴ Ba
(1980)
High-spin states in ¹³³ La
(1980)
Isomeric states in ¹³⁴ Ba
(1980)
New isomeric state in ¹⁴⁴ Eu
(1980)
K0 production in e+e− annihilations at 30 GeV center of mass energy. TASSO Collaboration
(1980)
Test of QED in e+e− annihilation at energies between 12 and 31.6 GeV. TASSO Collaboration
(1980)
Thermal synthesis of the optical pure pentapeptide derivative Z-(L)-Ala-(L)-Phe-Gly-(L)-Phe-Gly-OMe
(1980)
Isomeric state in ¹³⁴ La
(1981)
Isomeric state in ¹³⁶ La
(1981)
New side-bands in ¹³⁴ Ce
(1981)
Side-bands in ¹⁸⁰ Os
(1981)
Λ, Image production in e+e- annihilation at 33 GeV centre of mass energy. TASSO Collaboration
(1981)
Search for new sequential leptons in e+e- annihilation at petra energies. TASSO Collaboration
(1981)
High-spin states in ¹³³ La
(1982)
High spin states in ¹⁸⁸ Au
(1982)
The investigation of atomic resonance fluorescence has always been of special interest as a means for the determination of atomic parameters. In addition, information on the interaction mechanism between atoms and radiation can be obtained. In the standard fluorescence experiment the frequency distribution of the incident photons is larger than the natural width of the respective transition; as a consequence the correlation time in the photon-atom interaction is determined by the lifetime of the atoms in the excited state. With the development of lasers and especially of tunable dye lasers in recent years it became possible to study the case where the incident radiation has a spectral distribution which is narrower than the natural width. This corresponds to a correlation time of the incoming light wave which is much longer than the excited-state lifetime. In this chapter a survey of experiments on the resonance fluorescence of atoms in monochromatic laser fields will be given.