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Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.
One central challenge for self-driving cars is a proper path-planning. Once a trajectory has been found, the next challenge is to accurately and safely follow the precalculated path. The model-predictive controller (MPC) is a common approach for the lateral control of autonomous vehicles. The MPC uses a vehicle dynamics model to predict the future states of the vehicle for a given prediction horizon. However, in order to achieve real-time path control, the computational load is usually large, which leads to short prediction horizons. To deal with the computational load, the control algorithm can be parallelized on the graphics processing unit (GPU). In contrast to the widely used stochastic methods, in this paper we propose a deterministic approach based on grid search. Our approach focuses on systematically discovering the search area with different levels of granularity. To achieve this, we split the optimization algorithm into multiple iterations. The best sequence of each iteration is then used as an initial solution to the next iteration. The granularity increases, resulting in smooth and predictable steering angle sequences. We present a novel GPU-based algorithm and show its accuracy and realtime abilities with a number of real-world experiments.
Achilles tendon rupture (ATR) patients have persistent functional deficits in the triceps surae muscle–tendon unit (MTU). The complex remodeling of the MTU accompanying these deficits remains poorly understood. The purpose of the present study was to associate in vivo and in silico data to investigate the relations between changes inMTU properties and strength deficits inATR patients. Methods: Elevenmale subjects who had undergone surgical repair of complete unilateral ATR were examined 4.6 ± 2.0 (mean ± SD) yr after rupture. Gastrocnemius medialis (GM) tendon stiffness, morphology, and muscle architecture were determined using ultrasonography. The force–length relation of the plantar flexor muscles was assessed at five ankle joint angles. In addition, simulations (OpenSim) of the GM MTU force–length properties were performed with various iterations of MTU properties found between the unaffected and the affected side. Results: The affected side of the patients displayed a longer, larger, and stiffer GM tendon (13% ± 10%, 105% ± 28%, and 54% ± 24%, respectively) compared with the unaffected side. The GM muscle fascicles of the affected side were shorter (32% ± 12%) and with greater pennation angles (31% ± 26%). A mean deficit in plantarflexion moment of 31% ± 10% was measured. Simulations indicate that pairing an intact muscle with a longer tendon shifts the optimal angular range of peak force outside physiological angular ranges, whereas the shorter muscle fascicles and tendon stiffening seen in the affected side decrease this shift, albeit incompletely. Conclusions: These results suggest that the substantial changes in MTU properties found in ATR patients may partly result from compensatory remodeling, although this process appears insufficient to fully restore muscle function.
Für die Herstellung von metallischen Bauteilen wird in der heutigen Zeit eine Vielzahl von Verfahren auf dem Markt angeboten. Dabei stehen die additiven im Wettbewerb zu den konventionellen Verfahren. Die erreichbaren Oberflächenqualitäten der additiven sind nicht mit denen spanender Verfahren vergleichbar. Für diesen Beitrag wurde analysiert, ob sich ein mittels Selektivem Laserschmelzen (SLM) additiv hergestellter Edelstahl hinsichtlich seiner Oberflächenqualität nach der Zerspanung von einem umgeformten konventionell hergestellten Edelstahl gleicher Sorte unterscheidet.
The hot spots conjecture is only known to be true for special geometries. This paper shows numerically that the hot spots conjecture can fail to be true for easy to construct bounded domains with one hole. The underlying eigenvalue problem for the Laplace equation with Neumann boundary condition is solved with boundary integral equations yielding a non-linear eigenvalue problem. Its discretization via the boundary element collocation method in combination with the algorithm by Beyn yields highly accurate results both for the first non-zero eigenvalue and its corresponding eigenfunction which is due to superconvergence. Additionally, it can be shown numerically that the ratio between the maximal/minimal value inside the domain and its maximal/minimal value on the boundary can be larger than 1 + 10− 3. Finally, numerical examples for easy to construct domains with up to five holes are provided which fail the hot spots conjecture as well.
This paper discusses a new way of inflight power regeneration for electric or hybrid-electric driven general aviation aircraft with one powertrain for both configurations. Three different approaches for the shift from propulsion to regeneration mode are analyzed. Numerical cal-culation and wind tunnel results are compared and show the highest regeneration potential for the "Windmill" approach, where the propeller blades are flipped, and rotation is reversed. A combination of all regeneration approaches for a realistic flight mission is discussed.
An approach to automatically generate a dynamic energy simulation model in Modelica for a single existing building is presented. It aims at collecting data about the status quo in the preparation of energy retrofits with low effort and costs. The proposed method starts from a polygon model of the outer building envelope obtained from photogrammetrically generated point clouds. The open-source tools TEASER and AixLib are used for data enrichment and model generation. A case study was conducted on a single-family house. The resulting model can accurately reproduce the internal air temperatures during synthetical heating up and cooling down. Modelled and measured whole building heat transfer coefficients (HTC) agree within a 12% range. A sensitivity analysis emphasises the importance of accurate window characterisations and justifies the use of a very simplified interior geometry. Uncertainties arising from the use of archetype U-values are estimated by comparing different typologies, with best- and worst-case estimates showing differences in pre-retrofit heat demand of about ±20% to the average; however, as the assumptions made are permitted by some national standards, the method is already close to practical applicability and opens up a path to quickly estimate possible financial and energy savings after refurbishment.
The presented paper gives an overview of the most important and most common theories and concepts from the economic field of organisational change and is also enriched with quantitative publication data, which underlines the relevance of the topic. In particular, the topic presented is interwoven in an interdisciplinary way with economic psychological models, which are underpinned within the models with content from leading scholars in the field. The pace of change in companies is accelerating, as is technological change in our society. Adaptations of the corporate structure, but also of management techniques and tasks, are therefore indispensable. This includes not only the right approaches to employee motivation, but also the correct use of intrinsic and extrinsic motivational factors. Based on the hypothesis put forward by the scientist and researcher Rollinson in his book “Organisational behaviour and analysis” that managers believe motivational resources are available at all times, socio-economic and economic psychological theories are contrasted here in order to critically examine this statement. In addition, a fictitious company was created as a model for this work in order to illustrate the effects of motivational deficits in practice. In this context, the theories presented are applied to concrete problems within the model and conclusions are drawn about their influence and applicability. This led to the conclusion that motivation is a very individual challenge for each employee, which requires adapted and personalised approaches. On the other hand, the recommendations for action for supervisors in the case of motivation deficits also cannot be answered in a blanket manner, but can only be solved with the help of professional, expert-supported processing due to the economic-psychological realities of motivation. Identifying, analysing and remedying individual employee motivation deficits is, according to the authors, a problem and a challenge of great importance, especially in the context of rapidly changing ecosystems in modern companies, as motivation also influences other factors such as individual productivity. The authors therefore conclude that good motivation through the individual and customised promotion and further training of employees is an important point for achieving important corporate goals in order to remain competitive on the one hand and to create a productive and pleasant working environment on the other.
Background:
Additional stabilization of the “comma sign” in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair.
Purpose:
This in vitro investigation aimed to investigate the influence of a comma sign–directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair.
Study Design:
Controlled laboratory study.
Methods:
A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups.
Results:
The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596).
Conclusion:
The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading.
Clinical Relevance:
The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome.
Müll ist immer und überall vorhanden – auch wenn wir ihn nicht sehen. Gerade unsichtbarer Müll birgt für den Menschen und seine Umwelt erhebliche Gefahren, die durch seine Unsichtbarkeit irrelevant erscheinen. Die Publikation mit dem Titel mikromakro deckt durch verschiedene Artikel, Interviews und Texte die Gefahren auf, die durch den unsichtbaren Müll entstehen.
Ziel war es, eine Bookazine-Reihe zu konzipieren, die in sechs Ausgaben das Thema des unsichtbaren Mülls beleuchtet. Die erste Ausgabe zum Thema Kunststoff wurde exemplarisch gestaltet.
Zusätzlich zum redaktionellen Teil untermauern Infografiken die Texte faktisch und Fotoserien emotional.
Da unsichtbarer Müll auf zwei Ebenen zu finden ist – der Makro- (groß) und Mikroebene (klein) – wurde die Publikation inhaltlich zweigeteilt, sodass sich das Layout und die Fotoserien vom Mikro- und Makroteil unterscheiden.
Der Archäologische Park Xanten (APX) gilt als Deutschlands einziger archäologischer Freiluftpark. Er zeichnet sich im Verbund mit dem Römermuseum durch seine Lage auf dem historischen Grund einer römischen Metropole und seine kontinuierliche Forschungsaktivität aus und bietet so ein einzigartiges Umfeld von kultureller Relevanz. Ziel dieses Projektes war es, ein neues Erscheinungsbild zu entwickeln, welches klar die Thematik des Parks in den Medien erkennbar macht. Das Corporate Design dient dazu, die Inhalte des Verbundes in einem einheitlichen System medienübergreifend zu präsentieren. Das Design unterstützt den APX in seiner Funktion als Begegnungs- und Bildungsstätte. Aufgrund dessen ist es im Hinblick auf das Ziel relevant, das Interesse an Kulturgeschichte und Forschung zu wecken.
Living product: ein Ansatz, lebendige Organismen mit einem Produkt zu vereinen und nutzbar zu machen
(2021)
Diese Arbeit setzt sich mit der Frage auseinander, in welcher Form sich lebendige Organismen – hier insbesondere Pilze - in die Produktwelt integrieren lassen. In welcher Art und Weise beeinflusst ein Organismus das Produkterlebnis?
Im Rahmen dieser Arbeit sind vier verschiedene Produkte entstanden, die die Stärken des Materials Myzelium demonstrieren. Myzelium bezeichnet das sehr dichte Wurzelnetzwerk eines Pilzes. Dieses lebendige Netzwerk kann dazu genutzt werden, um organische Stoffe miteinander zu verwachsen und somit Formen entstehen zu lassen. Die so entstandenen Produkte sind in eine Konzeptumgebung eingebettet, in der der Verbrauchende die Natur durch naturnähere Produkte (Form, Material und gewachsene Strukturen) neu erlebt.
Gezeigt wird ein Packaging für Einmachgläser, ein Kressebeet, ein Wandregal und ein Teelicht.
Geochemical characterisation of hypersaline waters is difficult as high concentrations of salts hinder the analysis of constituents at low concentrations, such as trace metals, and the collection of samples for trace metal analysis in natural waters can be easily contaminated. This is particularly the case if samples are collected by non-conventional techniques such as those required for aquatic subglacial environments. In this paper we present the first analysis of a subglacial brine from Taylor Valley, (~ 78°S), Antarctica for the trace metals: Ba, Co, Mo, Rb, Sr, V, and U. Samples were collected englacially using an electrothermal melting probe called the IceMole. This probe uses differential heating of a copper head as well as the probe’s sidewalls and an ice screw at the melting head to move through glacier ice. Detailed blanks, meltwater, and subglacial brine samples were collected to evaluate the impact of the IceMole and the borehole pump, the melting and collection process, filtration, and storage on the geochemistry of the samples collected by this device. Comparisons between melt water profiles through the glacier ice and blank analysis, with published studies on ice geochemistry, suggest the potential for minor contributions of some species Rb, As, Co, Mn, Ni, NH4+, and NO2−+NO3− from the IceMole. The ability to conduct detailed chemical analyses of subglacial fluids collected with melting probes is critical for the future exploration of the hundreds of deep subglacial lakes in Antarctica.
For now, the Planetary Defense Conference Exercise 2021's incoming fictitious(!), asteroid, 2021 PDC, seems headed for impact on October 20th, 2021, exactly 6 months after its discovery. Today (April 26th, 2021), the impact probability is 5%, in a steep rise from 1 in 2500 upon discovery six days ago. We all know how these things end. Or do we? Unless somebody kicked off another headline-grabbing media scare or wants to keep civil defense very idle very soon, chances are that it will hit (note: this is an exercise!). Taking stock, it is barely 6 months to impact, a steadily rising likelihood that it will actually happen, and a huge uncertainty of possible impact energies: First estimates range from 1.2 MtTNT to 13 GtTNT, and this is not even the worst-worst case: a 700 m diameter massive NiFe asteroid (covered by a thin veneer of Ryugu-black rubble to match size and brightness), would come in at 70 GtTNT. In down to Earth terms, this could be all between smashing fireworks over some remote area of the globe and a 7.5 km crater downtown somewhere. Considering the deliberate and sedate ways of development of interplanetary missions it seems we can only stand and stare until we know well enough where to tell people to pack up all that can be moved at all and save themselves. But then, it could just as well be a smaller bright rock. The best estimate is 120 m diameter from optical observation alone, by 13% standard albedo. NASA's upcoming DART mission to binary asteroid (65803) Didymos is designed to hit such a small target, its moonlet Dimorphos. The Deep Impact mission's impactor in 2005 successfully guided itself to the brightest spot on comet 9P/Tempel 1, a relatively small feature on the 6 km nucleus. And 'space' has changed: By the end of this decade, one satellite communication network plans to have launched over 11000 satellites at a pace of 60 per launch every other week. This level of series production is comparable in numbers to the most prolific commercial airliners. Launch vehicle production has not simply increased correspondingly – they can be reused, although in a trade for performance. Optical and radio astronomy as well as planetary radar have made great strides in the past decade, and so has the design and production capability for everyday 'high-tech' products. 60 years ago, spaceflight was invented from scratch within two years, and there are recent examples of fast-paced space projects as well as a drive towards 'responsive space'. It seems it is not quite yet time to abandon all hope. We present what could be done and what is too close to call once thinking is shoved out of the box by a clear and present danger, to show where a little more preparedness or routine would come in handy – or become decisive. And if we fail, let's stand and stare safely and well instrumented anywhere on Earth together in the greatest adventure of science.
Mit MULO wurde eine Serie multifunktionaler Objekte für den Wohnbereich entworfen. In Zeiten des Überangebots und des ständigen Wohnraumwechsels soll der Nutzer dieser Objekte mit einem modernen und schlichten Design unterstützt werden, das zu jedem Anlass passt. Die minimalistische Ästhetik mit hohem Komfort orientiert sich dabei an den Bedürfnissen des Endverbrauchers.
Als Verwandlungskünstler bereichert MULO jeden Wohnraum. Die gesamte Serie ist unter der Berücksichtigung der schnelllebigen und sich wandelnden Welt entworfen worden. Mit multifunktionalen Objekten ist das Produkt den flexiblen Anforderungen und Bedürfnissen des Menschen gewachsen. Die Bereiche Wohnen, Leben, Arbeiten, Schlafen und Entspannen werden durch das Sofa- , das Tisch- und das Keramik-System optimal abgedeckt. Durch die Verwendung von nachhaltigen und recycelbaren Materialien, setzt MULO ein kleines Statement und hinterlässt nachhaltig Eindruck.
Inmitten des Stuttgarter Kessels findet sich Deutschlands einziger zoologisch-botanischer Garten wieder – die Wilhelma. Umrahmt von einer denkmalgeschützten Parkanlage des 19. Jahrhunderts mit maurischen Gebäuden lässt sie Bildung mit Freizeit verschmelzen. Das neue Erscheinungsbild positioniert die schwäbische Einrichtung sowohl als Ort des Zusammenkommens als auch der Erholung und Wissensvermittlung. Bereits vor dem Betreten der Wilhelma soll ihre besondere Charakteristik aufgezeigt und entscheidend von ähnlichen Institutionen distanziert werden. Das grundlegende Gestaltungskonzept rückt die Symbiose aus Zoologie, Botanik und Historie in den Vordergrund. Inspiriert von der maurischen Architektur basiert die Gesamtgestaltung auf feinen geometrischen Formen. Diese bieten Orientierung, unterstreichen die Vielfältigkeit der Wilhelma und vereinen sich darüber hinaus im Logo miteinander.
Die Allianz Chronischer Seltener Erkrankungen (ACHSE) ist das einzige krankheitsübergreifende Netzwerk von und für Menschen mit einer seltenen Erkrankung in Deutschland. Insgesamt sind 4 Millionen Menschen in Deutschland von einer der rund 8.000 seltenen Krankheiten betroffen.
Durch die Seltenheit der verschiedenen Krankheiten ist es oft schwer, Experten zu finden, die richtige Versorgung sicherzustellen oder Studien durchzuführen. Betroffene fühlen sich oft nicht wahrgenommen und alleine gelassen. Die ACHSE dient als unabhängige Schnittstelle und Knotenpunkt zwischen Betroffenen, Regierung, Politik und Wirtschaft. Gemeinsam bündeln sich hier 130 Patientenorganisationen unter einem Dach, um die Betroffenen in den Fokus zu rücken. Ziel der Bachelorarbeit ist die Entwicklung eines Erscheinungsbildes sowie einer Kampagne, die das Thema mehr ins Bewusstsein der Öffentlichkeit bringt und informiert.
Wir alle haben schon einmal von ihnen gehört. Die einen kennen sie aus dem Geschichtsunterricht, die anderen haben sie vielleicht auch schon mal bewusst oder unbewusst auf der Straße gesehen. Einige sind es sogar selbst. Die Rede ist von jüdischen Menschen in Deutschland.
In unserer Bundesrepublik wird die jüdische Bevölkerung unausweichlich mit dem Gedanken des Holocausts verbunden. Jüdinnen und Juden wird somit eine Identität zugesprochen, mit der sie nichts zu tun haben. Es findet eine Stigmatisierung statt. Dabei sind jüdische Menschen heutzutage so divers wie noch nie. Das Printmedium »Ich sehe was, was Du nicht siehst« beleuchtet diese selten wahrgenommene Diversität und zeigt durch spannende Interviews eine jüdische Welt, die außerhalb der NS-Verbrechen liegt. Darüber hinaus findet man Informationen zu verschiedenen jüdischen Bräuchen, historischen Ereignissen und interessanten Infografiken.
Rehabilitative body weight supported gait training aims at restoring walking function as a key element in activities of daily living. Studies demonstrated reductions in muscle and joint forces, while kinematic gait patterns appear to be preserved with up to 30% weight support. However, the influence of body weight support on muscle architecture, with respect to fascicle and series elastic element behavior is unknown, despite this having potential clinical implications for gait retraining. Eight males (31.9 ± 4.7 years) walked at 75% of the speed at which they typically transition to running, with 0% and 30% body weight support on a lower-body positive pressure treadmill. Gastrocnemius medialis fascicle lengths and pennation angles were measured via ultrasonography. Additionally, joint kinematics were analyzed to determine gastrocnemius medialis muscle–tendon unit lengths, consisting of the muscle's contractile and series elastic elements. Series elastic element length was assessed using a muscle–tendon unit model. Depending on whether data were normally distributed, a paired t-test or Wilcoxon signed rank test was performed to determine if body weight supported walking had any effects on joint kinematics and fascicle–series elastic element behavior. Walking with 30% body weight support had no statistically significant effect on joint kinematics and peak series elastic element length. Furthermore, at the time when peak series elastic element length was achieved, and on average across the entire stance phase, muscle–tendon unit length, fascicle length, pennation angle, and fascicle velocity were unchanged with respect to body weight support. In accordance with unchanged gait kinematics, preservation of fascicle–series elastic element behavior was observed during walking with 30% body weight support, which suggests transferability of gait patterns to subsequent unsupported walking.
Adapting augmented reality systems to the users’ needs using gamification and error solving methods
(2021)
Animations of virtual items in AR support systems are typically predefined and lack interactions with dynamic physical environments. AR applications rarely consider users’ preferences and do not provide customized spontaneous support under unknown situations. This research focuses on developing adaptive, error-tolerant AR systems based on directed acyclic graphs and error resolving strategies. Using this approach, users will have more freedom of choice during AR supported work, which leads to more efficient workflows. Error correction methods based on CAD models and predefined process data create individual support possibilities. The framework is implemented in the Industry 4.0 model factory at FH Aachen.
The fourth industrial revolution introduces disruptive technologies to production environments. One of these technologies are multi-agent systems (MASs), where agents virtualize machines. However, the agent's actual performances in production environments can hardly be estimated as most research has been focusing on isolated projects and specific scenarios. We address this gap by implementing a highly connected and configurable reference model with quantifiable key performance indicators (KPIs) for production scheduling and routing in single-piece workflows. Furthermore, we propose an algorithm to optimize the search of extrema in highly connected distributed systems. The benefits, limits, and drawbacks of MASs and their performances are evaluated extensively by event-based simulations against the introduced model, which acts as a benchmark. Even though the performance of the proposed MAS is, on average, slightly lower than the reference system, the increased flexibility allows it to find new solutions and deliver improved factory-planning outcomes. Our MAS shows an emerging behavior by using flexible production techniques to correct errors and compensate for bottlenecks. This increased flexibility offers substantial improvement potential. The general model in this paper allows the transfer of the results to estimate real systems or other models.
Industrie 4.0 stellt viele Herausforderungen an produzierende Unternehmen und ihre Beschäf-tigten. Innovative und effektive Trainingsstrategien sind erforderlich, um mit den sich schnell verändernden Produktionsumgebungen und neuen Fertigungstechnologien Schritt halten zu können. Virtual Reality (VR) bietet neue Möglichkeiten für On-the-Job, On-Demand- und Off-Premise-Schulungen. Diese Arbeit stellt ein neues VR Schulungssystem vor, welches sich flexible an unterschiedliche Trainingsobjekte auf Grundlage von Rezepten und CAD Modellen anpassen lässt. Das Konzept basiert auf gerichteten azyklischen Graphen und einem Level-system. Es ermöglicht eine benutzerindividuelle Lerngeschwindigkeit mittels visueller Ele-mente. Das Konzept wurde für einen mechanischen Anwendungsfall mit Industriekomponen-ten implementiert und in der Industrie 4.0-Modellfabrik der FH Aachen umgesetzt.
Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi- Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behavior of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behavior of the test structure and installations is investigated with and without base isolation. Furthermore, both firmly anchored and isolated components are taken into account to compare their dynamic behavior and interactions with each other. Artificial and synthetic ground motions are applied to study the seismic response at different PGA levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the numerical simulations to calibrate the tests on the prototype, the experimental setup of the investigated structure and installations, selected measurement data and finally describes preliminary experimental results.
The on-chip integration of multiple biochemical sensors based on field-effect electrolyte-insulator-semiconductor capacitors (EISCAP) is challenging due to technological difficulties in realization of electrically isolated EISCAPs on the same Si chip. In this work, we present a new simple design for an array of on-chip integrated, individually electrically addressable EISCAPs with an additional control gate (CG-EISCAP). The existence of the CG enables an addressable activation or deactivation of on-chip integrated individual CG-EISCAPs by simple electrical switching the CG of each sensor in various setups, and makes the new design capable for multianalyte detection without cross-talk effects between the sensors in the array. The new designed CG-EISCAP chip was modelled in so-called floating/short-circuited and floating/capacitively-coupled setups, and the corresponding electrical equivalent circuits were developed. In addition, the capacitance-voltage curves of the CG-EISCAP chip in different setups were simulated and compared with that of a single EISCAP sensor. Moreover, the sensitivity of the CG-EISCAP chip to surface potential changes induced by biochemical reactions was simulated and an impact of different parameters, such as gate voltage, insulator thickness and doping concentration in Si, on the sensitivity has been discussed.