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Peyre, Marie-Josephe
(2017)
Peyre, Antoine-Francois
(2017)
Patte, Pierre
(2017)
Ranson, Pierre
(2017)
Lepautre
(2015)
Die Staatliche Antikensammlung in München ist eine antike Kunstsammlung, bestehend aus zwei Kunsthäusern. Das Haus der Glyptothek befindet sich auf der Nordseite und die Antikensammlung auf der Südseite des Königsplatzes. Während die Glyptothek Skulpturen ausstellt, zeigt die Antikensammlung Gebrauchsgegenstände und Objekte aus der etruskischen, griechischen und römischen Epoche. Sie gehört mit ihrer Kunstsammlung zu den weltweit führenden ihrer Art. In seinem Vorhaben, das Kulturerbe zu wahren, legt das Museum besonders hohen Wert auf Bildung und Vermittlung. Um dies langfristig zu gewährleisten, ist ein ausgeglichenes Erscheinungsbild zwischen Klassik und Modernität unentbehrlich. Die griechische Stilepoche zeichnet sich in ihrer abstrakten Nutzung von geometrischen Grundformen aus. Im Zusammenspiel von geometrischen Formen und Abstrahierungen entsteht ein neues Erscheinungsbild.
The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice
(2018)
The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.
The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice
(2017)
Biopharmaceuticals such as antibodies are produced in cultivated mammalian cells, which must be monitored to comply with good manufacturing practice. We, therefore, developed a fully automated system comprising a specific exhaust gas analyzer, inline analytics and a corresponding algorithm to precisely determine the oxygen uptake rate, carbon dioxide evolution rate, carbon dioxide transfer rate, transfer quotient and respiratory quotient without interrupting the ongoing cultivation, in order to assess its reproducibility. The system was verified using chemical simulation experiments and was able to measure the respiratory activity of hybridoma cells and DG44 cells (derived from Chinese hamster ovary cells) with satisfactory results at a minimum viable cell density of ~2.0 × 10⁵ cells ml⁻¹. The system was suitable for both batch and fed-batch cultivations in bubble-aerated and membrane-aerated reactors, with and without the control of pH and dissolved oxygen.
Ga-doped Li7La3Zr2O12 garnet solid electrolytes exhibit the highest Li-ion conductivities among the oxide-type garnet-structured solid electrolytes, but instabilities toward Li metal hamper their practical application. The instabilities have been assigned to direct chemical reactions between LiGaO2 coexisting phases and Li metal by several groups previously. Yet, the understanding of the role of LiGaO2 in the electrochemical cell and its electrochemical properties is still lacking. Here, we are investigating the electrochemical properties of LiGaO2 through electrochemical tests in galvanostatic cells versus Li metal and complementary ex situ studies via confocal Raman microscopy, quantitative phase analysis based on powder X-ray diffraction, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and electron energy loss spectroscopy. The results demonstrate considerable and surprising electrochemical activity, with high reversibility. A three-stage reaction mechanism is derived, including reversible electrochemical reactions that lead to the formation of highly electronically conducting products. The results have considerable implications for the use of Ga-doped Li7La3Zr2O12 electrolytes in all-solid-state Li-metal battery applications and raise the need for advanced materials engineering to realize Ga-doped Li7La3Zr2O12for practical use.
Vermessung
(2006)
Vermessung
(2006)
Vermessung
(2016)
In this paper, the use of reinforcement learning (RL) in control systems is investigated using a rotatory inverted pendulum as an example. The control behavior of an RL controller is compared to that of traditional LQR and MPC controllers. This is done by evaluating their behavior under optimal conditions, their disturbance behavior, their robustness and their development process. All the investigated controllers are developed using MATLAB and the Simulink simulation environment and later deployed to a real pendulum model powered by a Raspberry Pi. The RL algorithm used is Proximal Policy Optimization (PPO). The LQR controller exhibits an easy development process, an average to good control behavior and average to good robustness. A linear MPC controller could show excellent results under optimal operating conditions. However, when subjected to disturbances or deviations from the equilibrium point, it showed poor performance and sometimes instable behavior. Employing a nonlinear MPC Controller in real time was not possible due to the high computational effort involved. The RL controller exhibits by far the most versatile and robust control behavior. When operated in the simulation environment, it achieved a high control accuracy. When employed in the real system, however, it only shows average accuracy and a significantly greater performance loss compared to the simulation than the traditional controllers. With MATLAB, it is not yet possible to directly post-train the RL controller on the Raspberry Pi, which is an obstacle to the practical application of RL in a prototyping or teaching setting. Nevertheless, RL in general proves to be a flexible and powerful control method, which is well suited for complex or nonlinear systems where traditional controllers struggle.
Solidification of silver-germanium alloys in an amorphous matrix aboard the space station Mir
(1993)
High resolution temperature measurement technique for materials sciences experiments in space
(1998)
The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.
his report summarizes the results of a workshop on Groupware related task design which took place at the International Conference on Supporting Group Work Group'99, Arizona, from 14 th to 17 th November 1999.
The workshop was addressed to people from different
viewpoints, backgrounds, and domains:
- Researchers dealing with questions of task analysis
and task modeling for Groupware application from an
academic point of view. They may contribute modelbased design
approaches or theoretically oriented
work
- Practitioners with experience in the design and
everyday use of groupware systems. They might refer
to the practical side of the topic: "real" tasks, "real"
problems, "real" users, etc.
Security Awareness ist derzeit ein viel diskutiertes Thema. Es reicht nicht, einfach nur ein paar technische Systeme (z.B. Firewalls) zu installieren, um ein angemessenes Schutzniveau zu erzielen. Neben einer guten Organisation von IT Security ist es auch notwendig, den Mitarbeiter einzubinden. Der vielzitierte "Faktor Mensch" ist derjenige, der die Technik korrekt anwenden muss und der durch falsches Verhalten technische und organisatorische Schutzmaßnahmen aushebeln kann. Deshalb reicht es nicht aus, wenn sich der Mitarbeiter der Gefahren bewusst ("aware") ist, er muss auch dementsprechend "sicher" handeln.
Mein Freund, die Uni
(2014)
K3 User Guide
(2000)
Erfolgreiches IT-Marketing
(2013)
Es existieren verschiedenste Arten von Spielen, die versuchen, die Motivation einer Spielsituation in einen ernsten Kontext zu überführen. In diesem Artikel wird der Überbegriff „Competence Developing Games“ definiert und anhand von Beispielen erläutert. Dafür werden Erkennungskriterien vorgestellt, entsprechende Spieltypen erläutert und eine Zuordnung durch-geführt.
Computer Supported Communication and Cooperation – Making Information Aware / Luczak, H. ; Wolf, M.
(1999)
Seit 2002 ist der Tierschutz fest im Grundgesetz verankert, jedoch herrscht immer noch ein enormes Ungleichgewicht bei der letztendlichen Durchsetzung gegenüber der Tiernutzungsinteressen. Die Nichteinhaltung des Tierschutzes stellt nicht nur aus Tierwohlsicht, sondern auch aus Klimaschutzgründen eine ernst zu nehmende Problematik dar, welche wir nur gemeinsam angehen können. Die Gesellschaft sollte sich über das eigene Konsumverhalten bewusst werden, gleichermaßen müssen auch überzeugende Alternativen aufgezeigt werden. Thematisch ist die Arbeit in drei Teile gegliedert. Die Geschichte, das Recht der Tiere und die Zukunftsaussichten stehen hier im Fokus. Wichtig ist es, den Istzustand neutral darzustellen, um die Fakten nicht zu harmonisieren. Die Publikation soll nicht abschrecken, vielmehr soll sie die Leser:innen motivieren, Dinge ändern zu wollen. Denn nur miteinander können wir friedlich „koexistieren“.
The development of Gossamer sail structures for solar sails contributes to a large field of future space applications like thin film solar generators, membrane antennas and drag sails. The focus of this paper is the development of a drag sail based on solar sail technology that could contribute to a reduction of space debris in low Earth orbits. The drag sail design and its connections to solar sail development, a first test on a sounding rocket, as well as the ongoing integration of the drag sail into a triple CubeSat is presented.
The manufacturing share of laser powder bed fusion (L-PBF) increases in industrial application, but still many process steps are manually operated. Additionally, it is not possible to achieve tight dimensional tolerances or low surfaces roughness. Hence, a process chain has to be set up to combine additive manufacturing (AM) with further machining technologies. To achieve a continuous workpiece flow as basis for further industrialization of L-PBF, the paper presents a novel substrate system and its application on L-PBF machines and post-processing. The substrate system consists of a zero-point clamping system and a matrix-like interface of contact pins to be substantially connected to the workpiece within the L-PBF process.
Harte Echtzeit für Windows
(1999)
Bussysteme
(2006)