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Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.
Solar Sail Trajectory Optimization for Intercepting, Impacting, and Deflecting Near-Earth Asteroids
(2005)
Solar Sail Kinetic Energy Impactor Trajectory Optimization for an Asteroid-Deflection Mission
(2007)
Solar sailcraft of the first generation technology development / Seboldt, Wolfgang ; Dachwald, Bernd
(2003)
Multiple Near-Earth Asteroid Rendezvous and Sample Return Using First Generation Solar Sailcraft
(2005)
Optimization of Interplanetary Rendezvous Trajectories for Solar Sailcraft Using a Neurocontroller
(2002)