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Background
Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices.
Methods
This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare & Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results.
Results
With a 10% fracture risk reduction, model A costs between $8,850 and $46,940 per quality-adjusted life-year ($/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side’s prophylaxis, the patient’s age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between $11,000/QALY and $74,000/QALY, which is below the defined willingness to pay threshold.
Conclusion
Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.
Contractile behavior of the gastrocnemius medialis muscle during running in simulated hypogravity
(2021)
Vigorous exercise countermeasures in microgravity can largely attenuate muscular degeneration, albeit the extent of applied loading is key for the extent of muscle wasting. Running on the International Space Station is usually performed with maximum loads of 70% body weight (0.7 g). However, it has not been investigated how the reduced musculoskeletal loading affects muscle and series elastic element dynamics, and thereby force and power generation. Therefore, this study examined the effects of running on the vertical treadmill facility, a ground-based analog, at simulated 0.7 g on gastrocnemius medialis contractile behavior. The results reveal that fascicle−series elastic element behavior differs between simulated hypogravity and 1 g running. Whilst shorter peak series elastic element lengths at simulated 0.7 g appear to be the result of lower muscular and gravitational forces acting on it, increased fascicle lengths and decreased velocities could not be anticipated, but may inform the development of optimized running training in hypogravity. However, whether the alterations in contractile behavior precipitate musculoskeletal degeneration warrants further study.
In: Unterrichtsblätter / Deutsche Telekom AG. 54. 2001. 7. S. 410-420 (11 S. ) Angesichts der zunehmenden Globalisierung von Informationen und Informationsdiensten können Inhalte (Contents) für mehrere unterschiedliche Dienste genutzt und auf verschiedenen Endgeräten ausgegeben werden. Hier setzt ein Content-Management-System (CMS) an, welches sowohl für die Kunden als auch für die Anbieter der unterschiedlich distribuierten Dienste Synergien und somit Einsparpotenziale bietet. Darüber hinaus werden für die Anbieter dieser Dienste durch die allgemeine Definition von Leistungstools und die Definition von Wertschöpfungsketten künftige Produktentwicklungen vereinheitlicht und optimiert werden. Mit der Entwicklung und Vertriebsfreigabe immer weiterer Informationsdienste, die von verschiedenen Dienste-Providern betrieben werden, ist der Bedarf an einer Koordinierung der Entwicklungen und Investitionen im Bereich der Content-Akquisition und des Content-Management (CM) bedeutend angestiegen. Neben Akquisition, lizenzrechtlichen Fragen und Verwaltung des im Rahmen von Diensten angebotenen Content rücken vor allem auch Fragen der Gestaltung von Content-Management-Plattformen (CMP) immer stärker in den Blickpunkt. Der Beitrag stellt die globalen Ergebnisse dar, die in einem Forschungs- und Entwicklungsauftrag des Zentralbereichs Innovationsmanagement der Deutschen Telekom zu diesem Thema ermittelt wurden. Es werden die Kernmodule für eine Content- Management-Plattform beschrieben, die die Anforderungen an die Bereitstellung vielfältiger Content-Angebote erfüllt. Die folgenden Themen werden behandelt: + Begriffsbestimmung, + Content- und Dienste-Portfolio, + Standard Content-Prozess, + synergetische Content-Plattform (sCP), + Modelle der sCP, + Aspekte beim Betrieb und + Nutzen eines Content-Management.
In the paper a lightning protection design concept for renewable energy hybrid-systems without power mains connection is described. Based on a risk analysis protection measures against direct strikes and overvoltages are shown in an overview. The design concept is realized exemplarily for the hybrid-system VATALI on the Greek island Crete. VATALI, not lightning protected at that time, was a victim of a lightning strike in the year 2000 causing destructions and damages of some mechanical and electrical components with costs of approx. 60.000 €. The hardware costs for the protection measures were about 15.000 €: about 50% of the costs are due to protection measures against direct strikes, 50% are due to overvoltage protection.
Applications of Graph Transformations with Industrial Relevance Lecture Notes in Computer Science, 2004, Volume 3062/2004, 434-439, DOI: http://dx.doi.org/10.1007/978-3-540-25959-6_33 This paper gives a brief overview of the tools we have developed to support conceptual design in civil engineering. Based on the UPGRADE framework, two applications, one for the knowledge engineer and another for architects allow to store domain specific knowledge and to use this knowledge during conceptual design. Consistency analyses check the design against the defined knowledge and inform the architect if rules are violated.
Shock waves, explosions, impacts or cavitation bubble collapses may generate stress waves in solids causing cracks or unexpected dammage due to focussing, physical nonlinearity or interaction with existing cracks. There is a growing interest in wave propagation, which poses many novel problems to experimentalists and theorists.
This paper compares several blade element theory (BET) method-based propeller simulation tools, including an evaluation against static propeller ground tests and high-fidelity Reynolds-Average Navier Stokes (RANS) simulations. Two proprietary propeller geometries for paraglider applications are analysed in static and flight conditions. The RANS simulations are validated with the static test data and used as a reference for comparing the BET in flight conditions. The comparison includes the analysis of varying 2D aerodynamic airfoil parameters and different induced velocity calculation methods. The evaluation of the BET propeller simulation tools shows the strength of the BET tools compared to RANS simulations. The RANS simulations underpredict static experimental data within 10% relative error, while appropriate BET tools overpredict the RANS results by 15–20% relative error. A variation in 2D aerodynamic data depicts the need for highly accurate 2D data for accurate BET results. The nonlinear BET coupled with XFOIL for the 2D aerodynamic data matches best with RANS in static operation and flight conditions. The novel BET tool PropCODE combines both approaches and offers further correction models for highly accurate static and flight condition results.
O conceito científico de Lideranca situaçional explica que um líder tem que ser uma pessoa de múltiplas Funções e Competências. Nas empresas alemaes tem muitos pessoas pensando ser líderes, mas no fundo eles são somente Administradores. a diferenca é o seguinte: alguem que é somente capaz de trabalhar com seu conhecimento e com seus ferramentas, já sabe muito, mas isso nao è suficiente para ter sucesso. Ele è de verdade somente um administrador. Pois para ser um Líder de verdade ele precisa além disso as competencias social e individual.
O Perfil Reiss apresenta no resultado uma visão da estrutura dos motivos e impulsos de uma pessoa. O ponto de saída para a análise do resultado é o conhecimento de que os motivos vitais (= valores e metas de sobrevivência) formam a moldura, na qual as competências e capacidades que uma pessoa possui possam se desabrochar de forma ideal. A partir desse princípio, não existe no Perfil Reiss nenhum resultado que se possa classificar como correto ou falso, nem como bom ou mau. Uma comparação entre o resultado do Perfil Reiss e o conteúdo de uma atividade apresentada ou ambicionada dá informação sobre até que ponto a capacidade de rendimento de uma pessoa nessa posição pode vir ou virá a se desenvolver por um longo tempo.
Die „Orgasmuslücke“ ist ein Begriff aus der Sexualforschung, der die Ungleichheit von Orgasmen zwischen den verschiedenen Geschlechtern und Sexualitäten beschreibt. Sie beruht dabei vor allem auf das problematische Verständnis von Sex, das durch verschiedene kulturelle Einflüsse vermittelt wird. Um über diese Einflüsse aufzuklären, wurde das Format „fuckfulness“ konzipiert. Mithilfe von animierten Videos und darauf aufbauendem Social-Media-Content befasst sich „fuckfulness“ ausführlich mit allen Hintergründen der Orgasmuslücke und gestaltet sexuelle Aufklärung neu. Durch junge und moderne Kommunikation wird das Projekt auch für eine jüngere Zielgruppe unterhaltsam. Ziel ist ein neues Verständnis von Sex, in dem die Bedürfnisse der Frau gleichberechtigt neben denen des Mannes stehen und entsprechende Beachtung finden. So soll die Orgasmuslücke schmaler werden, damit die Gleichstellung endlich auch in den eigenen vier Wänden gelebt werden kann.
Dieses Projekt hat zum Ziel, umfassend über Climate Engineering-Maßnahmen zu informieren und dabei insbesondere ihre Funktionsweise, Kosten und Risiken darzustellen. Die entstandene Plattform "Die Erde abkühlen!" bietet einen Einblick in die Lösungsansätze des Climate Engineerings durch die Verwendung von Storytelling. Sie ermöglicht Nutzer:innen einen Überblick über den aktuellen Stand der Klimaerwärmung sowie den Vergleich von Climate Engineering-Maßnahmen. Ein entwickeltes Bewertungssystem auf Grundlage der "Royal Society" sowie interaktive Infografiken geben Nutzer:innen einen umfassenden Einblick. Das Hauptziel des Projekts ist die digitale Transformation der Climate Engineering-Lösungsansätze. Dabei geht es nicht nur darum, über die Folgen der Klimaerwärmung zu informieren, sondern auch konkrete Lösungen aufzuzeigen. Durch die Entwicklung eines innovativen Storytellings wird die Thematik nicht nur dramaturgisch präsentiert, sondern ermöglicht es den Nutzer:innen auch, ihre eigene Wissensvertiefung zu steuern.
Background
Aminoacylases are highly promising enzymes for the green synthesis of acyl-amino acids, potentially replacing the environmentally harmful Schotten-Baumann reaction. Long-chain acyl-amino acids can serve as strong surfactants and emulsifiers, with application in cosmetic industries. Heterologous expression of these enzymes, however, is often hampered, limiting their use in industrial processes.
Results
We identified a novel mycobacterial aminoacylase gene from Mycolicibacterium smegmatis MKD 8, cloned and expressed it in Escherichia coli and Vibrio natriegens using the T7 overexpression system. The recombinant enzyme was prone to aggregate as inclusion bodies, and while V. natriegens Vmax™ could produce soluble aminoacylase upon induction with isopropyl β-d-1-thiogalactopyranoside (IPTG), E. coli BL21 (DE3) needed autoinduction with lactose to produce soluble recombinant protein. We successfully conducted a chaperone co-expression study in both organisms to further enhance aminoacylase production and found that overexpression of chaperones GroEL/S enhanced aminoacylase activity in the cell-free extract 1.8-fold in V. natriegens and E. coli. Eventually, E. coli ArcticExpress™ (DE3), which co-expresses cold-adapted chaperonins Cpn60/10 from Oleispira antarctica, cultivated at 12 °C, rendered the most suitable expression system for this aminoacylase and exhibited twice the aminoacylase activity in the cell-free extract compared to E. coli BL21 (DE3) with GroEL/S co-expression at 20 °C. The purified aminoacylase was characterized based on hydrolytic activities, being most stable and active at pH 7.0, with a maximum activity at 70 °C, and stability at 40 °C and pH 7.0 for 5 days. The aminoacylase strongly prefers short-chain acyl-amino acids with smaller, hydrophobic amino acid residues. Several long-chain amino acids were fairly accepted in hydrolysis as well, especially N-lauroyl-L-methionine. To initially evaluate the relevance of this aminoacylase for the synthesis of N-acyl-amino acids, we demonstrated that lauroyl-methionine can be synthesized from lauric acid and methionine in an aqueous system.
Conclusion
Our results suggest that the recombinant enzyme is well suited for synthesis reactions and will thus be further investigated.
Chapeau.cc : Mut zum Hut
(2007)
Ziel meiner Diplomarbeit ist es, mit einer Kampagne für das Tragen von Hüten bei jungen Menschen zu werben. Zugleich erscheint es mir wichtig, das Image des mit Traditionen beladenen Hutes alter Prägung zu verändern, ihn den heutigen Vorstellungen und Bedürfnissen gemäß zu präsentieren. Online-Plattform chapeau.cc Die Online-Plattform stellt die eigentliche Geschäftsbasis der Marke chapeau.cc dar, über die Hüte angeboten werden sollen. Damit wird eine Einkaufsplattform geschaffen, die Hut-Designer, Hersteller und junge Verbraucher zusammenbringt.
CardboardCastle
(2024)
„CardboardCastle“ ist ein 3D-Animationsfilm. Der Film zeigt die lebendig gewordene Welt zweier Königreiche aus Pappe, die in einem Streit um einen magischen Zauberstab verwickelt sind. Das Projekt beweist, dass es möglich ist, mit der Software „Blender“ einen vollwertigen und hochwertigen 3D-Animationsfilm zu erstellen. Dabei wurden alle Assets bis auf Texturen selbst hergestellt. Die virtuelle Pappe spielt hierbei eine fundamentale Rolle, für diese wurde ein vollkommen neuer Workflow entwickelt, welcher es ermöglicht, realistische Pappe zu visualisieren. „CardboardCastle“ setzt auf eine cinematische Inszenierung von Licht und vereint technisches Wissen mit unterhaltenden Inhalten. Dabei zeigt er die kindliche Vorstellungskraft und lädt die Zuschauer ein, sich an ihre eigenen kindlichen Fantasien zu erinnern.
Die Arbeit „Cape Town – Revisiting the Past“ setzt sich mit der Vergangenheit von Kapstadt auseinander. Kapstadt ist geprägt von einer beeindruckenden Geografie, Kultur, der Vergangenheit und den Menschen. Eine persönliche Verbindung nach Kapstadt und ein Familienarchiv aus aufbewahrten Publikationen, Postkarten und Fotos ermöglichen einen Blick in die vergangene Zeit. Verschiedene Materialien aus unterschiedlichen Zeiten werden verbunden und in einen gemeinsamen Kontext gebracht. Unabhängig davon, ob dies der erste Kontakt mit Kapstadt ist oder man den Ort bereits kennt, können Dinge neu entdeckt oder wiederentdeckt werden. Die Publikation schafft es mithilfe von Materialien und persönlichen Erinnerungen einen visuellen und informativen Einblick in das damalige Kapstadt zu geben. Dabei wird die Vielfalt der Region gezeigt und ein Gefühl eines Lebens vor Ort vermittelt.
An acetoin biosensor based on a capacitive electrolyte–insulator–semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance–voltage, and constant capacitance methods, respectively.
[Paper of the X International Symposium on Lightning Protection 9th - 13th November, 2009 - Curitiba, Brazil. 6 pages] The international standard IEC 62305-3, published in 2006, requires as an integral part of the lightning protection system (LPS) the consideration of a separation distance between the conductors of the LPS and metal and electrical installations inside the structure to be protected. IEC 62305-3 gives two different methods for this calculation: a standard, simplified approach and a more detailed approach, which differ especially regarding the treatment of the current sharing effect on the LPS conductors. Hence, different results for the separation distance are possible, leading to some discrepancies in the use of the standard. The standard approach defined in the main part (Clause 6.3) and in Annex C of the standard in some cases may lead to a severe oversizing of the required separation distance. The detailed approach described in Annex E naturally gives more correct results. However, a calculation of the current sharing amongst all parts of the air-termination and downconductor network is necessary, in many cases requiring the use of network analysis programs. In this paper simplified methods for the assessment of the current sharing are presented, which are easy to use as well as sufficiently adequate.