Refine
Year of publication
- 2019 (387) (remove)
Institute
- FH Aachen (74)
- Fachbereich Medizintechnik und Technomathematik (71)
- IfB - Institut für Bioengineering (45)
- Fachbereich Elektrotechnik und Informationstechnik (44)
- Fachbereich Luft- und Raumfahrttechnik (44)
- Fachbereich Wirtschaftswissenschaften (35)
- Fachbereich Bauingenieurwesen (28)
- Fachbereich Energietechnik (27)
- Fachbereich Maschinenbau und Mechatronik (27)
- INB - Institut für Nano- und Biotechnologien (20)
Document Type
- Article (123)
- Conference Proceeding (94)
- Administrative publication (72)
- Part of a Book (43)
- Book (25)
- Other (9)
- Doctoral Thesis (5)
- Patent (5)
- Review (4)
- Conference: Meeting Abstract (2)
Keywords
- Amtliche Mitteilung (68)
- Bachelor (31)
- Master (29)
- Prüfungsordnung (29)
- Lesbare Fassung (28)
- Studien- und Prüfungsordnung (21)
- Änderungsordnung (20)
- Bauingenieurwesen (17)
- Elektrotechnik (8)
- Holzingenieurwesen (6)
Kalkulation
(2019)
In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles’ nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil’s signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements.
The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.
Recognition of subjects with mild cognitive impairment (MCI) by the use of retinal arterial vessels.
(2019)
Baumaschinen
(2019)