Refine
Year of publication
- 2011 (189) (remove)
Institute
- Fachbereich Medizintechnik und Technomathematik (71)
- INB - Institut für Nano- und Biotechnologien (35)
- Fachbereich Elektrotechnik und Informationstechnik (31)
- IfB - Institut für Bioengineering (29)
- Fachbereich Chemie und Biotechnologie (22)
- Fachbereich Luft- und Raumfahrttechnik (16)
- Fachbereich Energietechnik (15)
- Fachbereich Maschinenbau und Mechatronik (12)
- Solar-Institut Jülich (11)
- Fachbereich Bauingenieurwesen (5)
Language
- English (189) (remove)
Document Type
- Article (130)
- Conference Proceeding (44)
- Part of a Book (8)
- Conference: Meeting Abstract (3)
- Book (2)
- Doctoral Thesis (2)
Keywords
- Pflanzenphysiologie (2)
- Pflanzenscanner (2)
- plant scanner (2)
- Aktionskunst (1)
- Anastomose (1)
- Anastomosis (1)
- Biomechanics (1)
- Biomechanik (1)
- Bioreaktor (1)
- Blutzellenlagerung (1)
The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143–145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143–ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.
Meiotic functions of RAD18
(2011)
In the RoboCup@Home domestic service robot competition, complex tasks such as "get the cup from the kitchen and bring it to the living room" or "find me this and that object in the apartment" have to be accomplished. At these competitions the robots may only be instructed by natural language. As humans use qualitative concepts such as "near" or "far", the robot needs to cope with them, too. For our domestic robot, we use the robot programming and plan language Readylog, our variant of Golog. In previous work we extended the action language Golog, which was developed for the high-level control of agents and robots, with fuzzy concepts and showed how to embed fuzzy controllers in Golog. In this paper, we demonstrate how these notions can be fruitfully applied to two domestic service robotic scenarios. In the first application, we demonstrate how qualitative fluents based on a fuzzy set semantics can be deployed. In the second program, we show an example of a fuzzy controller for a follow-a-person task.