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Meitner-Auger-electron emitters have a promising potential for targeted radionuclide therapy of cancer because of their short range and the high linear energy transfer of Meitner-Auger-electrons (MAE). One promising MAE candidate is 197m/gHg with its half-life of 23.8 h and 64.1 h, respectively, and high MAE yield. Gold nanoparticles (AuNPs) that are labelled with 197m/gHg could be a helpful tool for radiation treatment of glioblastoma multiforme when infused into the surgical cavity after resection to prevent recurrence. To produce such AuNPs, 197m/gHg was embedded into pristine AuNPs. Two different syntheses were tested starting from irradiated gold containing trace amounts of 197m/gHg. When sodium citrate was used as reducing agent, no 197m/gHg labelled AuNPs were formed, but with tannic acid, 197m/gHg labeled AuNPs were produced. The method was optimized by neutralizing the pH (pH = 7) of the Au/197m/gHg solution, which led to labelled AuNPs with a size of 12.3 ± 2.0 nm as measured by transmission electron microscopy. The labelled AuNPs had a concentration of 50 μg (gold)/mL with an activity of 151 ± 93 kBq/mL (197gHg, time corrected to the end of bombardment).
We present the production of 58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (58m/gCo and 56Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA−1 for 58mCo with a separation recovery of (75 ± 2) % of cobalt after one separation step utilizing LN-resin.
Density reduction effects on the production of [11C]CO2 in Nb-body targets on a medical cyclotron
(2023)
Medical isotope production of 11C is commonly performed in gaseous targets. The power deposition of the proton beam during the irradiation decreases the target density due to thermodynamic mixing and can cause an increase of penetration depth and divergence of the proton beam. In order to investigate the difference how the target-body length influences the operation conditions and the production yield, a 12 cm and a 22 cm Nb-target body containing N2/O2 gas were irradiated using a 13 MeV proton cyclotron. It was found that the density reduction has a large influence on the pressure rise during irradiation and the achievable radioactive yield. The saturation activity of [11C]CO2 for the long target (0.083 Ci/μA) is about 10% higher than in the short target geometry (0.075 Ci/μA).
This thesis aims at the presentation and discussion of well-accepted and new
imaging techniques applied to different types of flow in common hydraulic
engineering environments. All studies are conducted in laboratory conditions and
focus on flow depth and velocity measurements. Investigated flows cover a wide
range of complexity, e.g. propagation of waves, dam-break flows, slightly and fully
aerated spillway flows as well as highly turbulent hydraulic jumps.
Newimagingmethods are compared to different types of sensorswhich are frequently
employed in contemporary laboratory studies. This classical instrumentation as well
as the general concept of hydraulic modeling is introduced to give an overview on
experimental methods.
Flow depths are commonly measured by means of ultrasonic sensors, also known as
acoustic displacement sensors. These sensors may provide accurate data with high
sample rates in case of simple flow conditions, e.g. low-turbulent clear water flows.
However, with increasing turbulence, higher uncertainty must be considered.
Moreover, ultrasonic sensors can provide point data only, while the relatively large
acoustic beam footprint may lead to another source of uncertainty in case of
relatively short, highly turbulent surface fluctuations (ripples) or free-surface
air-water flows. Analysis of turbulent length and time scales of surface fluctuations
from point measurements is also difficult. Imaging techniques with different
dimensionality, however, may close this gap. It is shown in this thesis that edge
detection methods (known from computer vision) may be used for two-dimensional
free-surface extraction (i.e. from images taken through transparant sidewalls in
laboratory flumes). Another opportunity in hydraulic laboratory studies comes with
the application of stereo vision. Low-cost RGB-D sensors can be used to gather
instantaneous, three-dimensional free-surface elevations, even in flows with very
high complexity (e.g. aerated hydraulic jumps). It will be shown that the uncertainty
of these methods is of similar order as for classical instruments.
Particle Image Velocimetry (PIV) is a well-accepted and widespread imaging
technique for velocity determination in laboratory conditions. In combination with
high-speed cameras, PIV can give time-resolved velocity fields in 2D/3D or even as
volumetric flow fields. PIV is based on a cross-correlation technique applied to small
subimages of seeded flows. The minimum size of these subimages defines the
maximum spatial resolution of resulting velocity fields. A derivative of PIV for
aerated flows is also available, i.e. the so-called Bubble Image Velocimetry (BIV). This
thesis emphasizes the capacities and limitations of both methods, using relatively
simple setups with halogen and LED illuminations. It will be demonstrated that
PIV/BIV images may also be processed by means of Optical Flow (OF) techniques.
OF is another method originating from the computer vision discipline, based on the
assumption of image brightness conservation within a sequence of images. The
Horn-Schunck approach, which has been first employed to hydraulic engineering
problems in the studies presented herein, yields dense velocity fields, i.e. pixelwise
velocity data. As discussed hereinafter, the accuracy of OF competes well with PIV
for clear-water flows and even improves results (compared to BIV) for aerated flow
conditions. In order to independently benchmark the OF approach, synthetic images
with defined turbulence intensitiy are used.
Computer vision offers new opportunities that may help to improve the
understanding of fluid mechanics and fluid-structure interactions in laboratory
investigations. In prototype environments, it can be employed for obstacle detection
(e.g. identification of potential fish migration corridors) and recognition (e.g. fish
species for monitoring in a fishway) or surface reconstruction (e.g. inspection of
hydraulic structures). It can thus be expected that applications to hydraulic
engineering problems will develop rapidly in near future. Current methods have not
been developed for fluids in motion. Systematic future developments are needed to
improve the results in such difficult conditions.
Elastic transmission eigenvalues and their computation via the method of fundamental solutions
(2020)
A stabilized version of the fundamental solution method to catch ill-conditioning effects is investigated with focus on the computation of complex-valued elastic interior transmission eigenvalues in two dimensions for homogeneous and isotropic media. Its algorithm can be implemented very shortly and adopts to many similar partial differential equation-based eigenproblems as long as the underlying fundamental solution function can be easily generated. We develop a corroborative approximation analysis which also implicates new basic results for transmission eigenfunctions and present some numerical examples which together prove successful feasibility of our eigenvalue recovery approach.
Electric flight has the potential for a more sustainable and energy-saving way of aviation compared to fossil fuel aviation. The electric motor can be used as a generator inflight to regenerate energy during descent. Three different approaches to regenerating with electric propeller powertrains are proposed in this paper. The powertrain is to be set up in a wind tunnel to determine the propeller efficiency in both working modes as well as the noise emissions. Furthermore, the planned flight tests are discussed. In preparation for these tests, a yaw stability analysis is performed with the result that the aeroplane is controllable during flight and in the most critical failure case. The paper shows the potential for inflight regeneration and addresses the research gaps in the dual role of electric powertrains for propulsion and regeneration of general aviation aircraft.
This paper discusses a new way of inflight power regeneration for electric or hybrid-electric driven general aviation aircraft with one powertrain for both configurations. Three different approaches for the shift from propulsion to regeneration mode are analyzed. Numerical cal-culation and wind tunnel results are compared and show the highest regeneration potential for the "Windmill" approach, where the propeller blades are flipped, and rotation is reversed. A combination of all regeneration approaches for a realistic flight mission is discussed.
The development and operation of hybrid or purely electrically powered aircraft in regional air mobility is a significant challenge for the entire aviation sector. This technology is expected to lead to substantial advances in flight performance, energy efficiency, reliability, safety, noise reduction, and exhaust emissions. Nevertheless, any consumed energy results in heat or carbon dioxide emissions and limited electric energy storage capabilities suppress commercial use. Therefore, the significant challenges to achieving eco-efficient aviation are increased aircraft efficiency, the development of new energy storage technologies, and the optimization of flight operations. Two major approaches for higher eco-efficiency are identified: The first one, is to take horizontal and vertical atmospheric motion phenomena into account. Where, in particular, atmospheric waves hold exciting potential. The second one is the use of the regeneration ability of electric aircraft. The fusion of both strategies is expected to improve efficiency. The objective is to reduce energy consumption during flight while not neglecting commercial usability and convenient flight characteristics. Therefore, an optimized control problem based on a general aviation class aircraft has to be developed and validated by flight experiments. The formulated approach enables a development of detailed knowledge of the potential and limitations of optimizing flight missions, considering the capability of regeneration and atmospheric influences to increase efficiency and range.
Reducing poverty, protecting the planet, and improving life on earth for everyone are the essential goals of the "2030 Agenda for Sustainable Development"committed by the United Nations (UN). Achieving those goals will require technological innovation as well as their implementation in almost all areas of our business and day-to-day life. This paper proposes a high-level framework that collects and structures different uses cases addressing the goals defined by the UN. Hence, it contributes to the discussion by proposing technical innovations that can be used to achieve those goals. As an example, the goal "Climate Actionïs discussed in detail by describing use cases related to tackling biodiversity loss in order to conservate ecosystems.
The management of knowledge in organizations considers both established long-term processes and cooperation in agile project teams. Since knowledge can be both tacit and explicit, its transfer from the individual to the organizational knowledge base poses a challenge in organizations. This challenge increases when the fluctuation of knowledge carriers is exceptionally high. Especially in large projects in which external consultants are involved, there is a risk that critical, company-relevant knowledge generated in the project will leave the company with the external knowledge carrier and thus be lost. In this paper, we show the advantages of an early warning system for knowledge management to avoid this loss. In particular, the potential of visual analytics in the context of knowledge management systems is presented and discussed. We present a project for the development of a business-critical software system and discuss the first implementations and results.
The low-pressure system Bernd involved extreme rainfalls in the Western part of Germany in July 2021,
resulting in major floods, severe damages and a tremendous number of casualties. Such extreme events
are rare and full flood protection can never be ensured with reasonable financial means. But still, this
event must be starting point to reconsider current design concepts. This article aims at sharing some
thoughts on potential hazards, the selection of return periods and remaining risk with the focus on Germany.
We present new numerical results for shape optimization problems of interior Neumann eigenvalues. This field is not well understood from a theoretical standpoint. The existence of shape maximizers is not proven beyond the first two eigenvalues, so we study the problem numerically. We describe a method to compute the eigenvalues for a given shape that combines the boundary element method with an algorithm for nonlinear eigenvalues. As numerical optimization requires many such evaluations, we put a focus on the efficiency of the method and the implemented routine. The method is well suited for parallelization. Using the resulting fast routines and a specialized parametrization of the shapes, we found improved maxima for several eigenvalues.
The method of fundamental solutions is applied to the approximate computation of interior transmission eigenvalues for a special class of inhomogeneous media in two dimensions. We give a short approximation analysis accompanied with numerical results that clearly prove practical convenience of our alternative approach.
Mathematical morphology is a part of image processing that has proven to be fruitful for numerous applications. Two main operations in mathematical morphology are dilation and erosion. These are based on the construction of a supremum or infimum with respect to an order over the tonal range in a certain section of the image. The tonal ordering can easily be realised in grey-scale morphology, and some morphological methods have been proposed for colour morphology. However, all of these have certain limitations.
In this paper we present a novel approach to colour morphology extending upon previous work in the field based on the Loewner order. We propose to consider an approximation of the supremum by means of a log-sum exponentiation introduced by Maslov. We apply this to the embedding of an RGB image in a field of symmetric 2x2 matrices. In this way we obtain nearly isotropic matrices representing colours and the structural advantage of transitivity. In numerical experiments we highlight some remarkable properties of the proposed approach.
Direct sampling method via Landweber iteration for an absorbing scatterer with a conductive boundary
(2024)
In this paper, we consider the inverse shape problem of recovering isotropic scatterers with a conductive boundary condition. Here, we assume that the measured far-field data is known at a fixed wave number. Motivated by recent work, we study a new direct sampling indicator based on the Landweber iteration and the factorization method. Therefore, we prove the connection between these reconstruction methods. The method studied here falls under the category of qualitative reconstruction methods where an imaging function is used to recover the absorbing scatterer. We prove stability of our new imaging function as well as derive a discrepancy principle for recovering the regularization parameter. The theoretical results are verified with numerical examples to show how the reconstruction performs by the new Landweber direct sampling method.
We consider the numerical approximation of second-order semi-linear parabolic stochastic partial differential equations interpreted in the mild sense which we solve on general two-dimensional domains with a C² boundary with homogeneous Dirichlet boundary conditions. The equations are driven by Gaussian additive noise, and several Lipschitz-like conditions are imposed on the nonlinear function. We discretize in space with a spectral Galerkin method and in time using an explicit Euler-like scheme. For irregular shapes, the necessary Dirichlet eigenvalues and eigenfunctions are obtained from a boundary integral equation method. This yields a nonlinear eigenvalue problem, which is discretized using a boundary element collocation method and is solved with the Beyn contour integral algorithm. We present an error analysis as well as numerical results on an exemplary asymmetric shape, and point out limitations of the approach.
Analysis and computation of the transmission eigenvalues with a conductive boundary condition
(2022)
We provide a new analytical and computational study of the transmission eigenvalues with a conductive boundary condition. These eigenvalues are derived from the scalar inverse scattering problem for an inhomogeneous material with a conductive boundary condition. The goal is to study how these eigenvalues depend on the material parameters in order to estimate the refractive index. The analytical questions we study are: deriving Faber–Krahn type lower bounds, the discreteness and limiting behavior of the transmission eigenvalues as the conductivity tends to infinity for a sign changing contrast. We also provide a numerical study of a new boundary integral equation for computing the eigenvalues. Lastly, using the limiting behavior we will numerically estimate the refractive index from the eigenvalues provided the conductivity is sufficiently large but unknown.
Fields of asymmetric tensors play an important role in many applications such as medical imaging (diffusion tensor magnetic resonance imaging), physics, and civil engineering (for example Cauchy-Green-deformation tensor, strain tensor with local rotations, etc.). However, such asymmetric tensors are usually symmetrized and then further processed. Using this procedure results in a loss of information. A new method for the processing of asymmetric tensor fields is proposed restricting our attention to tensors of second-order given by a 2x2 array or matrix with real entries. This is achieved by a transformation resulting in Hermitian matrices that have an eigendecomposition similar to symmetric matrices. With this new idea numerical results for real-world data arising from a deformation of an object by external forces are given. It is shown that the asymmetric part indeed contains valuable information.