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Is part of the Bibliography
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The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.
Reinigungsprozesse in der Lebensmittelindustrie. Entwicklung eines Demonstrators zur Überwachung
(2017)
Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug–drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.
Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements.
In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner’s business model.
This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal.
An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time.
The capacitive electrolyte–insulator–semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte–insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors.
Software Stories Guide
(2017)
In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.
Herausgeber: Prof. Dipl.-Ing. Thomas Tünnemann
Katalog Layout; Thilo Haas, Matthias Funken
Lektorat: Gerd Götschen
Titelbild: Kevin Osterkamp
Fotos, Yvonne Albers | Fotografin und die jeweiligen Verfasserinnen
Impressum | Inhalt 01
Team | Die Besetzung 03
Thomas Tünnemann | Neo Forma 05
Projekte
Carolin Grün | Fare Luce 07
Anke Mannshausen | Tetto Galleggiante 11
Kevin Osterkamp | Azione e Reazione 15
Collin Hackenbroich | Fuori Dentro 21
Lynn Thomas | La Tramoggia 25
Miriam Azzab | l‘Incontro 29
Jonas Wübbe | Le Scale 35
Matthias Funken | Il Laboratorio 39
Moran Dorner | La Via 43
Thilo Haas | Le Scale Vicino 47
Frank Drehsen | Dietro l‘Angelo 51
Felix Fischer | La Capella 55
Thomas Tünnemann | Basilica di Argento 59
Esra Ulutas | Arco Rotondo di Speranza 63
Jana Tillmanns | Punto di Rottura 67
Henri Boh | Il Portale 71
Paul Brüggentisch | Silenzio in Movimento 75
Hermann Stuzmann | Scale Antincendio 79
Atmosphärisches
Auf die Küche | Kulinarisches 81
Carpe Diem | Fotografisches 87
The methodological discourse of mixed-methods research offers general procedures to combine quantitative and qualitative methods for investigating complex fields of research such as higher education. However, integrating different methods still poses considerable challenges. To move beyond general recommendations for mixed-methods research, this chapter proposes to discuss methodological issues with respect to a particular research domain. Taking current studies on the transition to higher education as an example, the authors first provide an overview of the potentials and limitations of quantitative and qualitative methods in the research domain. Second, they show the need for a conceptual framework grounded in the theory of the research object to guide the integration of different methods and findings. Finally, an example study that investigates transition with regard to the interplay of the individual student and the institutional context serves to illustrate the guiding role of theory. The framework integrates different theoretical perspectives on transition, informs the selection of the research methods, and defines the nexus of the two strands that constitute the mixed-methods design. As the interplay of individual and context is of concern for teaching and learning in general, the example presented may be fruitful for the wider field of higher education research.
Für Auftragschweißaufgaben existiert eine Vielzahl an verfahrenstechnischen
Prozessvarianten, die je nach Charakteristik und Anwendungsfall
ausgewählt werden. Ein Nachteil der vorwiegend verwendeten Metall-
Schutzgasschweißprozesse (MSG) für das Auftragschweißen ist durch die
direkte Kopplung von Drahtvorschub zu Energieeintrag gegeben. Die vorgestellte
Zweidraht-Prozessvariante kann durch die Ausbildung eines übertragenen
und eines nicht-übertragenen Lichtbogens die elektrische Leistung
beider Lichtbögen variieren und damit einen direkten Einfluss auf
die Prozessgrößen Abschmelzleistung und Aufschmelzgrad nehmen. Im
Speziellen besteht über die Entkopplung von Drahtvorschub zu Schweißstromstärke
die Möglichkeit eines niederenergetischen Betriebs trotz hoher
Drahtvorschubgeschwindigkeit. Damit lassen sich Aufschmelzgrade
unter 2% umsetzen und Abschmelzleistungen bis zu 15 kg/h realisieren.
Development and Testing of a Low NOX Micromix Combustion Chamber for an Industrial Gas Turbine
(2017)
The Micromix combustion principle, based on cross-flow mixing of air and hydrogen, promises low emission applications in future gas turbines. The Micromix combustion takes place in several hundreds of miniaturized diffusion-type micro-flames. The major advantage is the inherent safety against flash-back and low NOx-emissions due to a very short residence time of reactants in the flame region. The paper gives insight into the Micromix design and scaling procedure for different energy densities and the interaction of scaling laws and key design drivers in gas turbine integration. Numerical studies, experimental testing, gas turbine integration and interface considerations are evaluated. The aerodynamic stabilization of the miniaturized flamelets and the resulting flow field, flame structure and NOx formation are analysed experimentally and numerically. The results show and confirm the successful adaption of the low NOx Micromix characteristics for a range of different nozzle sizes, energy densities and thermal power output.
Peyre, Marie-Josephe
(2017)
Peyre, Antoine-Francois
(2017)
Patte, Pierre
(2017)
Ranson, Pierre
(2017)
Names of individuals
(2017)
Small Claims Regulation
(2017)
Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution.
Energy-efficient components do not automatically lead to energy-efficient systems. Technical Operations Research (TOR) shifts the focus from the single component to the system as a whole and finds its optimal topology and operating strategy simultaneously. In previous works, we provided a preselected construction kit of suitable components for the algorithm. This approach may give rise to a combinatorial explosion if the preselection cannot be cut down to a reasonable number by human intuition. To reduce the number of discrete decisions, we integrate laws derived from similarity theory into the optimization model. Since the physical characteristics of a production series are similar, it can be described by affinity and scaling laws. Making use of these laws, our construction kit can be modeled more efficiently: Instead of a preselection of components, it now encompasses whole model ranges. This allows us to significantly increase the number of possible set-ups in our model. In this paper, we present how to embed this new formulation into a mixed-integer program and assess the run time via benchmarks. We present our approach on the example of a ventilation system design problem.
In times of planned obsolescence the demand for sustainability keeps growing. Ideally, a technical system is highly reliable, without failures and down times due to fast wear of single components. At the same time, maintenance should preferably be limited to pre-defined time intervals. Dispersion of load between multiple components can increase a system’s reliability and thus its availability inbetween maintenance points. However, this also results in higher investment costs and additional efforts due to higher complexity. Given a specific load profile and resulting wear of components, it is often unclear which system structure is the optimal one. Technical Operations Research (TOR) finds an optimal structure balancing availability and effort. We present our approach by designing a hydrostatic transmission system.
Momentan finden in vielen Branchen umfassende Veränderungen von Märkten und Wertschöpfungsketten statt, welche auch als Digitale Transformation bezeichnet werden. In diesem Zusammenhang wird das Internet der Dinge (Internet of Things, IoT) als ein wichtiger technischer Enabler der Veränderungen angesehen. Primäre Ziele des IoT sind die Steuerung physischer Gegen-stände aus der Distanz und das Erfassen von Informationen aus dem Umfeld dieser Gegenstände. Welche neuen Geschäfts-bzw. Partnermodelle entstehen durch die gemeinsame Nutzung von IoT-Daten und Big-Data-Technologien und welcher qualitative Mehrwert wird dadurch geschaffen? Als Antwort wird in diesem Beitrag ein Bewertungsrahmen zur qualitativen Wertschöpfungsanalyse von IoT vorgeschlagen. Anhand dieses Bewertungsrahmens wird ein Anwendungsfall untersucht, der in anonymisierter Form an konkrete Praxisprojekte angelehnt ist. Konkret wird ein Anwendungsfall betrachtet, der eine Abfallwirtschaft 2.0 basierend auf dem Einsatz von IoT vorschlägt. Aus den Untersuchungsergebnissen gehen beispielsweise Erkenntnisse hervor, wie Geschäftsmodelle auf Basis eines unentgeltlichen Informationsaustauschs durch IoT gestaltet werden können.
Kritische Infrastrukturen sind primäre Ziele krimineller Hacker. Der Deutsche Bundestag reagierte darauf am 25. Juli 2015 mit einem Gesetz zur Verbesserung der Sicherheit von ITSystemen, dem IT-Sicherheitsgesetz. Dies verlangt von Betreibern kritischer Infrastrukturen, angemessene Mindeststandards für organisatorische und technische Sicherheit zu implementieren, um den Betrieb und die Verfügbarkeit dieser Infrastruktur zu gewährleisten. Telekommunikationsunternehmen sind einerseits von diesem Gesetz in besonderem Maße betroffen und verfügen andererseits mit dem Rahmenwerk enhanced Telecom Operations Map (eTOM) über ein international anerkanntes Referenzmodell zur Gestaltung von Geschäftsprozessen in dieser Branche. Da sämtliche Telekommunikationsunternehmen in Deutschland verpflichtet sind, das Gesetz innerhalb eines bestimmten Zeitrahmens zu implementieren, präsentiert dieser Beitrag einen Vorschlag zur Erweiterung von eTOM um die relevanten Anforderungen des deutschen IT-Sicherheitsgesetzes.
Primäre Ziele des Internets der Dinge sind die Steuerung physischer Gegenstände aus der Distanz und das Erfassen von Informationen aus dem Umfeld dieser Gegenstände. Dazu werden Hardwarekomponenten in Gegenstände des täglichen Lebens und die Umwelt integriert. Mithilfe von Informations- und Kommunikationstechnologien entsteht hieraus das Internet der Dinge (Internet of Things, IoT). Vor einem Jahr wurde mit Narrowband Internet of Things (NB-IoT) eine Technologie die es ermöglicht, Hardwarekomponenten energieeffizient und unmittelbar über das Mobilfunknetz zu vernetzen. Gegenstände werden dadurch über große Reichweiten eigenständig kommunikationsfähig. Das IoT steht mit NB-IoT vor einem gestiegenen Nutzenpotenzial, da eine zunehmende Anzahl miteinander verbundener Gegenstände und der Austausch größerer Datenmengen realisierbar sind. Damit sind aus wirtschaftlicher Sicht neue, innovative Anwendungsfälle des IoT möglich, die auch bereits in der Praxis diskutiert werden. In diesem Beitrag wird anhand eines konkreten Anwendungsfalls untersucht, welche neuen Geschäfts- bzw. Partnermodelle durch die gemeinsame Nutzung von NB-IoT-Daten und Big Data-Technologien entstehen und welcher qualitative Mehrwert für die an einem Anwendungsfall beteiligten Stakeholder geschaffen wird. Dazu wird – einem konstruktionsorientierten Forschungsansatz folgend – ein Bewertungsrahmen zur qualitativen Wertschöpfungsanalyse von NB-IoT entwickelt, der u.a. auf der Schablone nach Cockburn und dem Business Model Canvas basiert. Anhand dieses Bewertungsrahmens wird ein Anwendungsfall untersucht, der in anonymisierter Form an konkrete Praxisprojekte angelehnt ist. Konkret wird ein Anwendungsfall betrachtet, der einen Fahrradverleih 2.0 basierend auf dem Einsatz von NB-IoT vorschlägt. Aus den Untersuchungsergebnissen gehen beispielsweise Erkenntnisse hervor, wie Geschäftsmodelle auf
The telecommunications industry is currently going through a major transformation. In this context, the enhanced Telecom Operations Map (eTOM) is a domain-specific process reference model that is offered by the industry organization TM Forum. In practice, eTOM is well accepted and confirmed as de facto standard. It provides process definitions and process flows on different levels of detail. This article discusses the reference modeling of eTOM, i.e., the design, the resulting artifact, and its evaluation based on three project cases. The application of eTOM in three projects illustrates the design approach and concrete models on strategic and operational levels. The article follows the Design Science Research (DSR) paradigm. It contributes with concrete design artifacts to the transformational needs of the telecommunications industry and offers lessons-learned from a general DSR perspective.
Kundenanforderungen an Netzwerke haben sich in den vergangenen Jahren stark verändert. Mit NFV und SDN sind Unternehmen technisch in der Lage, diesen gerecht zu werden. Die Provider stehen jedoch vor großen Herausforderungen: Insbesondere Produkte und Prozesse müssen angepasst und agiler werden, um die Stärken von NFV und SDN zum Kundenvorteil auszuspielen.